On evaluating how well a biomarker can predict treatment response with survival data

One of the objectives of personalized medicine is to take treatment decisions based on a biomarker measurement. Therefore, it is often interesting to evaluate how well a biomarker can predict the response to a treatment. To do so, a popular methodology consists of using a regression model and testing for an interaction between treatment assignment and biomarker. However, the existence of an interaction is not sufficient for a biomarker to be predictive. It is only necessary. Hence, the use of the marker‐by‐treatment predictiveness curve has been recommended. In addition to evaluate how well a single continuous biomarker predicts treatment response, it can further help to define an optimal threshold. This curve displays the risk of a binary outcome as a function of the quantiles of the biomarker, for each treatment group. Methods that assume a binary outcome or rely on a proportional hazard model for a time‐to‐event outcome have been proposed to estimate this curve. In this work, we propose some extensions for censored data. They rely on a time‐dependent logistic model, and we propose to estimate this model via inverse probability of censoring weighting. We present simulations results and three applications to prostate cancer, liver cirrhosis, and lung cancer data. They suggest that a large number of events need to be observed to define a threshold with sufficient accuracy for clinical usefulness. They also illustrate that when the treatment effect varies with the time horizon which defines the outcome, then the optimal threshold also depends on this time horizon.     

Throughput and delay analysis of an opportunistic tree algorithm

Tree algorithms are a well-known class of random access algorithms with a provable maximum stable throughput under the infinite population model (as opposed to ALOHA or the binary exponential backoff algorithm). In this article, we propose a tree algorithm for opportunistic spectrum usage in cognitive radio networks. A channel in such a network is shared among so-called primary and secondary users, where the secondary users are allowed to use the channel only if there is no primary user activity. The tree algorithm designed in this article can be used by the secondary users to share the channel capacity left by the primary users.

We analyze the maximum stable throughput and mean packet delay of the secondary users by developing a tree structured Quasi-Birth Death Markov chain under the assumption that the primary user activity can be modeled by means of a finite state Markov chain and that packets lengths follow a discrete phase-type distribution.

Numerical experiments provide insight on the effect of various system parameters and indicate that the proposed algorithm is able to make good use of the bandwidth left by the primary users.     

Analysis of some ruin-related quantities in a Markov-modulated risk model

In this paper, we study the joint Laplace transform and probability generating function of some random quantities that occur in each environment state by the time of ruin in a Markov-modulated risk process. These quantities include the duration spent in each state, the number of claims and the aggregate amount of claims that occurred in each state by the time of ruin. Explicit formulae for the joint transforms, given the initial surplus, and the initial and terminal environment states, are expressed in terms of a matrix version of the scale function. Moments and covariances of these ruin-related quantities are obtained and numerical illustrations are presented. The joint transform of the duration spent in each state, the number of claims, and the aggregate amount of claims that occurred in each state by the time the surplus attains a certain level are also investigated.     

论现代汉语中的“T1+（的）+T2”结构

现代汉语中存在着这样一种特殊的复合时间结构——T1+（的）+T2,T1、T2均是具有指示性的时点。在言语交际过程中, 人们常使用“T1+（的）+T2”这类复合时间结构的语言表达式,将原来具有一定距离的“事件”（包括已然事件和未然事件）拉回 到现时,从而产生加强现场感的语用效果,且站在说话人角度,具有积极的交际效果。     

A股上市公司变相财务操纵对行业估值的影响

关于上市公司利润操控的相关研究主要是将净利润作为一个事关操控的敏感指标,但在监管与被监管双方努力的博弈下,其可被操纵的潜力已被充分挖掘。从实证角度关注上市公司财务操纵的其他可操作途径,其中就包括一些看似合理的变相财务操纵手段。按照2001年中国证监会公布的《上市公司行业分类指引》,把我国上市企业分为13个行业,对不同行业内企业2003—2013年部分主观可操控的财务指标与其所在行业的平均市盈率进行格兰杰因果检验和回归分析,结果表明,一些行业内企业的部分财务指标与其所在行业的平均市盈率存在领先与滞后关系,并且影响作用显著。     

平稳性检验方法的有效性研究

平稳性检验是时间序列分析的重要研究内容,现有检验方法的性能缺乏系统的比较分析。文章从样本长度的视角研究平稳性检验方法的性能,采用ADF检验、PP检验、KPSS检验和LMC检验四种方法展开实证研究。仿真实验结果表明:时间序列数据长度会对检验方法的准确率产生明显的影响,数据长度较小时检验准确率偏低;数据长度增大时可以提升检验方法的准确率,但仍未能达到100%的上限值。当样本长度较小时,这些方法的检验统计量的渐进分布难以满足,因此其实际检验效果值得探究。样本长度是有限的,因此渐进分布检验方式的改进空间有限,新的检验方式值得探究。     

The Comparison of Performances of Widely Used Cointegration Tests

The aim of this study is to compare performances of commonly cointegration tests used in literature in terms of their empirical power and type I error probabilty for various sample sizes. As a result of the study, it has been found that some tests are not appropriate in testing cointegration in terms of empirical power and type I error probability. As a result of simulation study, λ_max test for any values of ρ and sample sizes have been found most appropriate test in conclusion.     

Robust Smoothed Rank Estimation Methods for Accelerated Failure Time Model Allowing Clusters

Smoothed Gehan rank estimation methods are widely used in accelerated failure time (AFT) models with/without clusters. However, most methods are sensitive to outliers in the covariates. In order to solve this problem, we propose robust approaches based on the smoothed Gehan rank estimation methods for the AFT model, allowing for clusters by employing two different weight functions. Simulation studies show that the proposed methods outperform existing smoothed rank estimation methods regarding their biases and standard deviations when there are outliers in the covariates. The proposed methods are also applied to a real dataset from the “Major cardiovascular interventions” study.     

Asymmetric Forecast Densities for U.S. Macroeconomic Variables from a Gaussian Copula Model of Cross-Sectional and Serial Dependence

Most existing reduced-form macroeconomic multivariate time series models employ elliptical disturbances, so that the forecast densities produced are symmetric. In this article, we use a copula model with asymmetric margins to produce forecast densities with the scope for severe departures from symmetry. Empirical and skew t distributions are employed for the margins, and a high-dimensional Gaussian copula is used to jointly capture cross-sectional and (multivariate) serial dependence. The copula parameter matrix is given by the correlation matrix of a latent stationary and Markov vector autoregression (VAR). We show that the likelihood can be evaluated efficiently using the unique partial correlations, and estimate the copula using Bayesian methods. We examine the forecasting performance of the model for four U.S. macroeconomic variables between 1975:Q1 and 2011:Q2 using quarterly real-time data. We find that the point and density forecasts from the copula model are competitive with those from a Bayesian VAR. During the recent recession the forecast densities exhibit substantial asymmetry, avoiding some of the pitfalls of the symmetric forecast densities from the Bayesian VAR. We show that the asymmetries in the predictive distributions of GDP growth and inflation are similar to those found in the probabilistic forecasts from the Survey of Professional Forecasters. Last, we find that unlike the linear VAR model, our fitted Gaussian copula models exhibit nonlinear dependencies between some macroeconomic variables. This article has online supplementary material.