Sample Size Calculation for the Therapeutic Equivalence Problem

A method is proposed for the sample size calculation in the case of therapeutic equivalence of two pharmaceuticals, when the decision is based on post-treatment differences and the post-treatment values are dependent on the pretreatment ones. When the correlation coefficient is large (over 0.7), it is shown that sample size calculation (and the corresponding hypothesis test) based on the sample statistic formed by the mean difference of the post–pre differences of each group has smaller variance and hence leads to smaller sample sizes.     

Testing Variability in the Two-Sample Case

A number of robust methods for testing variability have been reported in previous literature. An examination of these procedures for a wide variety of populations confirms their general robustness. Shoemaker's improvement of the F test extends that test use to a realistic variety of population shapes. However, a combination of the Brown–Forsythe and O'Brien methods based on testing kurtosis is shown to be conservative for a wide range of sample sizes and population distributions. The composite test is also shown to be more powerful in most conditions than other conservative procedures.     

Estimation of the Proportion of Defective Units by Using Group Testing Under the Existence of a Threshold of Detection

Group testing procedures, in which groups containing several units are tested without testing each unit, are widely used as cost-effective procedures in estimating the proportion of defective units in a population. A problem arises when we apply these procedures to the detection of genetically modified organisms (GMOs), because the analytical instrument for detecting GMOs has a threshold of detection. If the group size (i.e., the number of units within a group) is large, the GMOs in a group are not detected due to the dilution even if the group contains one unit of GMOs. Thus, most people conventionally use a small group size (which we call conventional group size) so that they can surely detect the existence of defective units if at least one unit of GMOs is included in the group. However, we show that we can estimate the proportion of defective units for any group size even if a threshold of detection exists; the estimate of the proportion of defective units is easily obtained by using functions implemented in a spreadsheet. Then, we show that the conventional group size is not always optimal in controlling a consumer's risk, because such a group size requires a larger number of groups for testing.     

Statistical Certification of Software Systems

Common software release procedures based on statistical techniques try to optimize the trade-off between further testing costs and costs due to remaining errors. We propose new software release procedures where the aim is to certify with a certain confidence level that the software does not contain errors. The underlying model is a discrete time model similar to the geometric Moranda model. The decisions are based on a mix of classical and Bayesian approaches to sequential testing and do not require any assumption on the initial number of errors.     

A specification strategy for order determination in arma models

In this paper a specification strategy is proposed for the determination of the orders in ARMA models. The strategy is based on two newly defined concepts: the q-conditioned partial auto-regressive function and the p-conditioned partial moving average function. These concepts are similar to the generalized partial autocorrelation function which has been recently suggested for order determination. The main difference is that they are defined and employed in connection with an asymptotically efficient estimation method instead of the rather inefficient generalized Yule-Walker method. The specification is performed by using sequential Wald type tests. In contrast to the traditional testing of hypotheses, these tests use critical values which increase with the sample size at an appropriate rate     

Estimation from smallest values

A two sample cest is proposea ior Liie hypuLiiefexo in.; LUSL observations from a second sample are equivalent, in distribution, to the smallest of r independent realisations of the first sample.

Assuming H to be true the efficiency of parameter estimation for the exponential and normal distributions is then considered     

Coherent Frequentism: A Decision Theory Based on Confidence Sets

By representing fair betting odds according to one or more pairs of confidence set estimators, dual parameter distributions called confidence posteriors secure the coherence of actions without any prior distribution. This theory reduces to the maximization of expected utility when the pair of posteriors is induced by an exact or approximate confidence set estimator or when a reduction rule is applied to the pair. Unlike the p-value, the confidence posterior probability of an interval hypothesis is suitable as an estimator of the indicator of hypothesis truth since it converges to 1 if the hypothesis is true or to 0 otherwise.     

Bonferroni-type Plug-in Procedure Controlling Generalized Familywise Error Rate

Consider the multiple hypotheses testing problem controlling the generalized familywise error rate k-FWER, the probability of at least k false rejections. We propose a plug-in procedure based on the estimation of the number of true null hypotheses. Under the independence assumption of the p-values corresponding to the true null hypotheses, we first introduce the least favorable configuration (LFC) of k-FWER for Bonferroni-type plug-in procedure, then we construct a plug-in k-FWER-controlled procedure based on LFC. For dependent p-values, we establish the asymptotic k-FWER control under some mild conditions. Simulation studies suggest great improvement over generalized Bonferroni test and generalized Holm test.     

A Bivariate Distribution for the Reliability Analysis of Failure Data in Presence of a Forewarning or Primer Event

This article presents a bivariate distribution for analyzing the failure data of mechanical and electrical components in presence of a forewarning or primer event whose occurrence denotes the inception of the failure mechanism that will cause the component failure after an additional random time. The characteristics of the proposed distribution are discussed and several point estimators of parameters are illustrated and compared, in case of complete sampling, via a large Monte Carlo simulation study. Confidence intervals based on asymptotic results are derived, as well as procedures are given for testing the independence between the occurrence time of the forewarning event and the additional time to failure. Numerical applications based on failure data of cable insulation specimens and of two-component parallel systems are illustrated.     

Finite Sample Modifications of the Granger Non Causality Test in Cointegrated Vector Autoregressions

This article deals with the Granger non causality test in cointegrated vector autoregressive processes. We propose a new testing procedure that yields an asymptotically standard distribution and performs well in small samples by combining the standard Wald test and the generalized inverse procedure. We also propose a few simple modifications to the test statistics in order to help our procedure perform better in finite samples. Monte Carlo simulations show that our procedure works better than the conventional approach.