TESTING THE AGREEMENT OF TWO QUANTITATIVE ASSAYS IN INDIVIDUAL MEANS

ABSTRACT

Existing approaches for the statistical evaluation of the agreement of two quantitative assays in terms of individual means are either based on a linear model and some stringent assumptions or comparisons of averages of individual means. Furthermore, the related statistical tests for some of these approaches are not valid in the sense that the sizes of these tests are not exactly the same as the nominal size even asymptotically. In this paper we propose a new method, which produces exact statistical tests that are easy to compute. When independent replicates are available, the proposed method requires very little or no assumption on the individual error variances. Simulation results show that the proposed tests perform better than some existing tests. Some examples are presented for illustration.     

LIMIT THEOREMS FOR ASYMPTOTICALLY MINIMAX ESTIMATION OF A DISTRIBUTION WITH INCREASING FAILURE RATE UNDER A RANDOM MIXED CENSORSHIP/TRUNCATION MODEL

ABSTRACT

The search for optimal non-parametric estimates of the cumulative distribution and hazard functions under order constraints inspired at least two earlier classic papers in mathematical statistics: those of Kiefer and Wolfowitz[1] Kiefer, J. and Wolfowitz, J. 1976. Asymptotically Minimax Estimation of Concave and Convex Distribution Functions. Z. Wahrsch. Verw. Gebiete, 34: 73–85. [Crossref], [Web of Science ®] , [Google Scholar] and Grenander[2] Grenander, U. 1956. On the Theory of Mortality Measurement. Part II. Scand. Aktuarietidskrift J., 39: 125–153.  [Google Scholar] respectively. In both cases, either the greatest convex minorant or the least concave majorant played a fundamental role. Based on Kiefer and Wolfowitz's work, Wang3-4 Wang, J.L. 1986. Asymptotically Minimax Estimators for Distributions with Increasing Failure Rate. Ann. Statist., 14: 1113–1131. Wang, J.L. 1987. Estimators of a Distribution Function with Increasing Failure Rate Average. J. Statist. Plann. Inference, 16: 415–427.   found asymptotically minimax estimates of the distribution function F and its cumulative hazard function Λ in the class of all increasing failure rate (IFR) and all increasing failure rate average (IFRA) distributions. In this paper, we will prove limit theorems which extend Wang's asymptotic results to the mixed censorship/truncation model as well as provide some other relevant results. The methods are illustrated on the Channing House data, originally analysed by Hyde.5-6 Hyde, J. 1977. Testing Survival Under Right Censoring and Left Truncation. Biometrika, 64: 225–230. Hyde, J. 1980. “Survival Analysis with Incomplete Observations”. In Biostatistics Casebook 31–46. New York: Wiley Series in Probability and Mathematical Statistics: Applied Probability and Statistics.       

Nonparametric Bayes factors based on empirical likelihood ratios

Bayes methodology provides posterior distribution functions based on parametric likelihoods adjusted for prior distributions. A distribution-free alternative to the parametric likelihood is use of empirical likelihood (EL) techniques, well known in the context of nonparametric testing of statistical hypotheses. Empirical likelihoods have been shown to exhibit many of the properties of conventional parametric likelihoods. In this paper, we propose and examine Bayes factors (BF) methods that are derived via the EL ratio approach. Following Kass and Wasserman (1995), we consider Bayes factors type decision rules in the context of standard statistical testing techniques. We show that the asymptotic properties of the proposed procedure are similar to the classical BF's asymptotic operating characteristics. Although we focus on hypothesis testing, the proposed approach also yields confidence interval estimators of unknown parameters. Monte Carlo simulations were conducted to evaluate the theoretical results as well as to demonstrate the power of the proposed test.     

Statistical inference for partially time-varying coefficient errors-in-variables models

This paper studies the partially time-varying coefficient models where some covariates are measured with additive errors. In order to overcome the bias of the usual profile least squares estimation when measurement errors are ignored, we propose a modified profile least squares estimator of the regression parameter and construct estimators of the nonlinear coefficient function and error variance. The proposed three estimators are proved to be asymptotically normal under mild conditions. In addition, we introduce the profile likelihood ratio test and then demonstrate that it follows an asymptotically χ²${\chi }^2$ distribution under the null hypothesis. Finite sample behavior of the estimators is investigated via simulations too.     

Forecasting Vector ARMA Processes With Systematically Missing Observations

The following two predictors are compared for time series with systematically missing observations: (a) A time series model is fitted to the full series X_t , and forecasts are based on this model, (b) A time series model is fitted to the series with systematically missing observations Y _τ, and forecasts are based on the resulting model. If the data generation processes are known vector autoregressive moving average (ARMA) processes, the first predictor is at least as efficient as the second one in a mean squared error sense. Conditions are given for the two predictors to be identical. If only the ARMA orders of the generation processes are known and the coefficients are estimated, or if the process orders and coefficients are estimated, the first predictor is again, in general, superior. There are, however, exceptions in which the second predictor, using seemingly less information, may be better. These results are discussed, using both asymptotic theory and small sample simulations. Some economic time series are used as illustrative examples.     

Prediction Techniques for Box–Cox Regression Models

This article reviews several techniques useful for forming point and interval predictions in regression models with Box-Cox transformed variables. The techniques reviewed—plug-in, mean squared error analysis, predictive likelihood, and stochastic simulation—take account of nonnormality and parameter uncertainty in varying degrees. A Monte Carlo study examining their small-sample accuracy indicates that uncertainty about the Box–Cox transformation parameter may be relatively unimportant. For certain parameters, deterministic point predictions are biased, and plug-in prediction intervals are also biased. Stochastic simulation, as usually carried out, leads to badly biased predictions. A modification of the usual approach renders stochastic simulation predictions largely unbiased.     

A New PC-Based Test for Varian's Weak Separability Conditions

This article develops a new method to evaluate revealed preference separability conditions. In contrast to previous studies, our results generally find weak separability, even when datasets have some measurement error. In addition, revealed preference and weak separability appear robust to measurement error, different price distributions, and alternative preference settings. Measurement error generally results in relatively few violations of revealed preference or weak separability.     

基于目标导向的银行理财产品最优费率研究

建立基于银行目标导向的理财产品费率模型,通过对不同目标下银行行为的讨论,得出理财产品费率调整的一个分析框架。研究发现：存在使银行的经济效益和社会效益综合提升程度最大的最优理财产品费率;最优费率不是固定值,而是一个动态概念;单纯考虑经济效益时,银行将调高理财产品费率;银行调高理财产品费率,将提升自身综合目标的实现程度;银行调低理财产品费率,并不改变银行的综合目标。     

Modifications of the Empirical Likelihood Interval Estimation with Improved Coverage Probabilities

The empirical likelihood (EL) technique has been well addressed in both the theoretical and applied literature in the context of powerful nonparametric statistical methods for testing and interval estimations. A nonparametric version of Wilks theorem (Wilks, 1938 Wilks , S. S. ( 1938 ). The large-sample distribution of the likelihood ratio for testing composite hypotheses . Annals of Mathematical Statistics 9 : 60 – 62 .[Crossref] , [Google Scholar]) can usually provide an asymptotic evaluation of the Type I error of EL ratio-type tests. In this article, we examine the performance of this asymptotic result when the EL is based on finite samples that are from various distributions. In the context of the Type I error control, we show that the classical EL procedure and the Student's t-test have asymptotically a similar structure. Thus, we conclude that modifications of t-type tests can be adopted to improve the EL ratio test. We propose the application of the Chen (1995 Chen , L. ( 1995 ). Testing the mean of skewed distributions . Journal of the American Statistical Association 90 : 767 – 772 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) t-test modification to the EL ratio test. We display that the Chen approach leads to a location change of observed data whereas the classical Bartlett method is known to be a scale correction of the data distribution. Finally, we modify the EL ratio test via both the Chen and Bartlett corrections. We support our argument with theoretical proofs as well as a Monte Carlo study. A real data example studies the proposed approach in practice.