Summary of the Workshop on Issues in Risk Assessment: Quantitative Methods for Developmental Toxicology

This report summarizes the proceedings of a conference on quantitative methods for assessing the risks of developmental toxicants. The conference was planned by a subcommittee of the National Research Council's Committee on Risk Assessment Methodology ⁴ in conjunction with staff from several federal agencies, including the U.S. Environmental Protection Agency, U.S. Food and Drug Administration, U.S. Consumer Products Safety Commission, and Health and Welfare Canada. Issues discussed at the workshop included computerized techniques for hazard identification, use of human and animal data for defining risks in a clinical setting, relationships between end points in developmental toxicity testing, reference dose calculations for developmental toxicology, analysis of quantitative dose-response data, mechanisms of developmental toxicity, physiologically based pharmacokinetic models, and structure-activity relationships. Although a formal consensus was not sought, many participants favored the evolution of quantitative techniques for developmental toxicology risk assessment, including the replacement of lowest observed adverse effect levels (LOAELs) and no observed adverse effect levels (NOAELs) with the benchmark dose methodology.     

有错检验情况下标准型抽样方案的设计

本文给出了在有错检验情况下标准型抽样方案的设计方法，讨论了误检概率ｐ，ｐ′对抽样方案的影响，并给出抽样方案的实际应用。     

Intuitive Toxicology: Expert and Lay Judgments of Chemical Risks

Human beings have always been intuitive toxicologists, relying on their senses of sight, taste, and smell to detect harmful or unsafe food, water, and air. As we have come to recognize that our senses are not adequate to assess the dangers inherent in exposure to a chemical substance, we have created the sciences of toxicology and risk assessment to perform this function. Yet despite this great effort to overcome the limitations of intuitive toxicology, it has become evident that even our best scientific methods still depend heavily on extrapolations and judgments in order to infer human health risks from animal data. Many observers have acknowledged the inherent subjectivity in the assessment of chemical risks and have indicated a need to examine the subjective or intuitive elements of expert and lay risk judgments. We have begun such an examination by surveying members of the Society of Toxicology and the lay public about basic toxicological concepts, assumptions, and interpretations. Our results demonstrate large differences between toxicologists and laypeople, as well as differences between toxicologists working in industry, academia, and government. In addition, we find that toxicologists are sharply divided in their opinions about the ability to predict a chemical's effect on human health on the basis of animal studies. We argue that these results place the problems of risk communication in a new light. Although the survey identifies misconceptions that experts should clarify for the public, it also suggests that controversies over chemical risks may be fueled as much by limitations of the science of risk assessment and disagreements among experts as by public misconceptions.     

Professional Perspectives on Decision Making about the Long-term Care of Older People

With the increasing pressure on social and health care resources,professionals have to be more explicit in their decision makingregarding the long-term care of older people. This groundedtheory study used 19 focus groups and nine semi-structured interviews(99 staff in total) to explore professional perspectives onthis decision making. Focus group participants and intervieweescomprised care managers, social workers, consultant geriatricians,general medical practitioners, community nurses, home care managers,occupational therapists and hospital discharge support staff.The emerging themes spanned context, clients, families and services.Decisions were often prompted by a crisis, hindering professionalsseeking to make a measured assessment. Fear of burglary andassault, and the willingness and availability of family to helpwere major factors in decisions about living at home. Serviceavailability in terms of public funding for community care,the availability of home care workers and workload pressureson primary care services influenced decision ‘thresholds’regarding admission to institutional care. Assessment toolsdesigned to assist decision making about the long-term careof older people need to take into account the critical aspectsof individual fears and motivation, family support and the availabilityof publicly funded services as well as functional and medicalneeds.     

辅酶B_(12)模型化合物n-C_3H_7Co(salen)(γ—pic)的合成和表征

本文用配体置换法合成了烷基钴Schiff碱配合物n—C_3H_ 7Co(salen)(γ—pie)(正丙基·4-甲基吡啶·双水杨醛合乙二亚胺合钴(Ⅱ))。并进行了元素分析、红外光谱、紫外光谱、核磁共振等性质表征。     

Ordinal utility models of decision making under uncertainty

This paper studies two models of rational behavior under uncertainty whose predictions are invariant under ordinal transformations of utility. The quantile utility model assumes that the agent maximizes some quantile of the distribution of utility. The utility mass model assumes maximization of the probability of obtaining an outcome whose utility is higher than some fixed critical value. Both models satisfy weak stochastic dominance. Lexicographic refinements satisfy strong dominance.The study of these utility models suggests a significant generalization of traditional ideas of riskiness and risk preference. We define one action to be riskier than another if the utility distribution of the latter crosses that of the former from below. The single crossing property is equivalent to a minmax spread of a random variable. With relative risk defined by the single crossing criterion, the risk preference of a quantile utility maximizer increases with the utility distribution quantile that he maximizes. The risk preference of a utility mass maximizer increases with his critical utility value.     

基于风险规避和公平偏好的供应链收益共享契约协调研究

在一个简单的二级供应链系统中,建立了供应商和零售商同时具有风险规避和公平偏好的收益共享契约协调模型,通过修正、扩展FS效用收益模型,先后考察并分析了分散决策和集中决策下供应链的协调状态,研究发现,供应商和零售商的风险规避系数和公平偏好系数及收益份额必须满足特定的条件,收益共享契约才能使系统供应链整体达到协调状态;在此基础上,对风险规避和公平偏好因素进行敏感度分析,得到供应商和零售商行为偏好系数对供应链及成员最优订货量的影响;最后进行演化博弈算例分析和结论验证,体现了该协调模型的有效性和实用性。由此说明供应商和零售商的风险规避和公平偏好因素同时作用会改变系统供应链协调时的最优订货量,并对决策人的决策行为产生很大的影响。     

考虑多种安全库存策略的选址-库存问题研究

考虑多种安全设置策略的物流网络的选址-库存问题,不仅是选址、订货、运输和库存的集成优化,还需要考虑多种不同的安全库存设置和转运策略。因此,本文深入讨论了二级物流网络中的六种安全库存设置策略,构建了六种考虑不同安全库存设置的选址-库存模型。在考虑集中设置安全库存时,集中安全库存需要通过转载运输实现,因此需要将转载运输成本引入选址-库存模型之中,使新的选址-库存模型更加科学合理。另外,针对六种新的选址-库存模型,提出了基于个体成本差异分配的遗传算法,迭代搜索选址、分配、库存设置策略的优化组合。最后,通过数据实验验证了模型的有效性：（1）安全库存与转载运输之间存在此消彼长的背反关系;（2）安全库存设置和转载运输策略对总成本的影响取决于两种费率权重情况。本文的研究可以为二级物流网络的选址、订货和安全库存策略集成优化决策提供参考依据。     

基于银行-资产双边网络模型的系统性风险及投资策略研究

受近几年的国际金融危机及金融全球化的影响,对金融系统的系统性风险的研究已成为国内外学者的关注热点。考虑到当前基于"银行-资产-银行"间接传播渠道的相关研究相对匮乏,本文基于银行-资产双边网络模型来分析银行系统性风险。首先,使用中国47家上市银行2018年的资产负债表数据构建了中国银行系统的双边网络模型,研究分析各类资产遭受冲击时外部冲击、降价出售效应及银行所持有的各类资产占银行总资产的比例对银行系统性风险的影响。然后,引入系统性冲击方式,通过设置具有不同属性的两大类资产并生成四种冲击事件来构建银行的投资策略模型,从资产视角探讨银行最优的投资策略。研究发现,外部冲击与降价出售效应这两个产生系统性风险的影响因素在一定区间值时会产生叠加效应,使银行系统性风险急剧增加;五种资产类中,贷款类资产对外部冲击最敏感;分析发现在各类资产冲击下都未倒闭的所有银行的资产组合具有一定的相似性;进一步研究发现银行系统中存在着最优的资产组合,使得银行在稳定的同时能获取最大收益,并且资产负债比越大的银行其风险承受能力越强,从而可以选择更激进的投资策略来追求高收益。     

重要数据跨境流动背景下风险路径的识别与分级

重要数据的跨境流动引发了数据安全、国家安全等风险挑战。风险路径的识别和分级是对重要数据跨境流动进行预警管理的重要内容。本文基于复杂网络中的二分网络模型,对重要数据的跨境流动进行研究。首先,通过重要数据跨境流动的二分网络和关联网络识别风险路径;其次,构建基于网络结构和接收节点属性的目标风险路径方法以计算其风险值;最后,对我国某重要行业跨境流动的数据开展实证分析,验证算法的有效性和精准度。本文旨在为重要数据跨境流动的预警管理提供量化方法,有效预防重要数据跨境流动带来的风险,提升我国数据治理能力。