Bayesian analysis of spatial data using different variance and neighbourhood structures

In disease mapping, the overall goal is to study the incidence or mortality risk caused by a specific disease in a number of geographical regions. It is common to assume that the response variable follows a Poisson distribution, whose average rate can be explained by a group of covariates and a random effect. For this random effect, it is considered conditional autoregressive (CAR) models, which carry information about the neighbourhood relationship between the regions. The focus of this paper was to explore and compare some CAR models proposed in the literature. An application with epidemiological data was conducted to model the risk of death due to Crohn's Disease and Ulcerative Colitis in the State of São Paulo – Brazil. Finally, a simulation study was done to strengthen the results and assess the performance of the models in the presence of various levels of spatial dependence.     

On Sampling with Prescribed Second‐order Inclusion Probabilities

Abstract. Methods to perform fixed size sampling with prescribed second‐order inclusion probabilities are presented. The focus is on a conditional Poisson design of order 2, a CP(2) design. It is an exponential design of quadratic type and it is carefully studied. In particular, methods to find the suitable values of the parameters and methods to sample are described. Small examples illustrate.     

Comparison of three-dimensional profiles over time

In this paper, we describe an analysis for data collected on a three-dimensional spatial lattice with treatments applied at the horizontal lattice points. Spatial correlation is accounted for using a conditional autoregressive model. Observations are defined as neighbours only if they are at the same depth. This allows the corresponding variance components to vary by depth. We use the Markov chain Monte Carlo method with block updating, together with Krylov subspace methods, for efficient estimation of the model. The method is applicable to both regular and irregular horizontal lattices and hence to data collected at any set of horizontal sites for a set of depths or heights, for example, water column or soil profile data. The model for the three-dimensional data is applied to agricultural trial data for five separate days taken roughly six months apart in order to determine possible relationships over time. The purpose of the trial is to determine a form of cropping that leads to less moist soils in the root zone and beyond. We estimate moisture for each date, depth and treatment accounting for spatial correlation and determine relationships of these and other parameters over time.     

The performance of subset response surface designs for estimating third order terms

Response surface designs are widely used in industries like chemicals, foods, pharmaceuticals, bioprocessing, agrochemicals, biology, biomedicine, agriculture and medicine. One of the major objectives of these designs is to study the functional relationship between one or more responses and a number of quantitative input factors. However, biological materials have more run to run variation than in many other experiments, leading to the conclusion that smaller response surface designs are inappropriate. Thus designs to be used in these research areas should have greater replication. Gilmour (2006) introduced a wide class of designs called “subset designs” which are useful in situations in which run to run variation is high. These designs allow the experimenter to fit the second order response surface model. However, there are situations in which the second order model representation proves to be inadequate and unrealistic due to the presence of lack of fit caused by third or higher order terms in the true response surface model. In such situations it becomes necessary for the experimenter to estimate these higher order terms. In this study, the properties of subset designs, in the context of the third order response surface model, are explored.     

Asymptotic normality of a conditional hazard function estimate in the single index for quasi-associated data

Abstract

The main goal of this paper is to study the estimation of the conditional hazard function of a scalar response variable Y given a hilbertian random variable X in functional single-index model. We construct an estimator of this nonparametric function and we study its asymptotic properties, under quasi-associated structure. Precisely, we establish the asymptotic normality of the constructed estimator. We carried out simulation experiments to examine the behavior of this asymptotic property over finite sample data.     

复合Poisson风险模型下的生存概率

通过研究得出了在复合 Pisson模型下,当赔付服从指数分布时有限时间内的生存概率的拉普拉斯变换公式.     

Characterizations of discrete distributions based on conditional expectations of record values

r -th record values subject to (r + 1)-th record values, record mean function, from a distribution of discrete type. We give some properties of the record mean function and an explicit expression for the distribution function based on its record mean function, which allows us to characterize particular discrete distributions using the record mean functions. Received: January 4, 1999; revised version: September 27, 1999     

Conditional approval: discussion points from the PSI conditional approval expert group

The European Agency for the Evaluation of Medicinal Products has recently completed the consultation of a draft guidance on how to implement conditional approval. This route of application is available for orphan drugs, emergency situations and serious debilitating or life-threatening diseases. Although there has been limited experience in implementing conditional approval to date, PSI (Statisticians in the Pharmaceutical Industry) sponsored a meeting of pharmaceutical statisticians with an interest in the area to discuss potential issues. This article outlines the issues raised and resulting discussions, based on the group's interpretation of the legislation. Conditional approval seems to fit well with the accepted regulatory strategy in HIV. In oncology, conditional approval may be most likely when (a) compelling phase II data are available using accepted clinical outcomes (e.g. progression/recurrence-free survival or overall survival) and Phase III has been planned or started, or (b) when data are available using a surrogate endpoint for clinical outcome (e.g. response rate or biochemical measures) from a single-arm study in rare tumours with high response, compared with historical data. The use of interim analyses in Phase III for supporting conditional approval raises some challenging issues regarding dissemination of information, maintenance of blinding, potential introduction of bias, ethics, switching, etc.     

基于状态转移信息对FF三因子模型的改进

以1995年6月-2005年12月期间在我国沪深A股市场上市的全部股票为样本,本文实证发现,在新的样本期间,FF三因子模型不能对组合收益作出完全的解释。为了基于现代金融理论的基本观点对组合收益作出完全解释,本文利用状态转移信息对无条件的FF三因子模型进行改进,实证发现,改进后的状态转移的条件定价模型对我国股市的组合收益作出了完全解释。由此得出结论认为,在解释组合收益时,状态转移的条件定价模型是一个优于无条件FF三因子模型的模型。     

刑法因果关系浅析

弄清了刑法的因果关系,即弄清了犯罪行为因果关系的本质,在确认犯罪问题上就能更好的判断一个人对其行为结果负什么样的刑事责任。同时刑法的因果关系也是一个争论最多的问题,对于因果关系的必然性与偶然性,条件说与原因说,都是现在中外刑法研究的重点问题之一。正确的区别及认识它们对于研究刑法因果关系有重要意义。