Semiparametric Time-Varying Coefficients Regression Model for Longitudinal Data

Abstract.  In this paper, we consider a semiparametric time-varying coefficients regression model where the influences of some covariates vary non-parametrically with time while the effects of the remaining covariates follow certain parametric functions of time. The weighted least squares type estimators for the unknown parameters of the parametric coefficient functions as well as the estimators for the non-parametric coefficient functions are developed. We show that the kernel smoothing that avoids modelling of the sampling times is asymptotically more efficient than a single nearest neighbour smoothing that depends on the estimation of the sampling model. The asymptotic optimal bandwidth is also derived. A hypothesis testing procedure is proposed to test whether some covariate effects follow certain parametric forms. Simulation studies are conducted to compare the finite sample performances of the kernel neighbourhood smoothing and the single nearest neighbour smoothing and to check the empirical sizes and powers of the proposed testing procedures. An application to a data set from an AIDS clinical trial study is provided for illustration.     

Covariate Adjusted Correlation Analysis via Varying Coefficient Models

Abstract.  We propose covariate adjusted correlation (Cadcor) analysis to target the correlation between two hidden variables that are observed after being multiplied by an unknown function of a common observable confounding variable. The distorting effects of this confounding may alter the correlation relation between the hidden variables. Covariate adjusted correlation analysis enables consistent estimation of this correlation, by targeting the definition of correlation through the slopes of the regressions of the hidden variables on each other and by establishing a connection to varying-coefficient regression. The asymptotic distribution of the resulting adjusted correlation estimate is established. These distribution results, when combined with proposed consistent estimates of the asymptotic variance, lead to the construction of approximate confidence intervals and inference for adjusted correlations. We illustrate our approach through an application to the Boston house price data. Finite sample properties of the proposed procedures are investigated through a simulation study.     

Empirical likelihood inference for a common mean in the presence of heteroscedasticity

The authors develop empirical likelihood (EL) based methods of inference for a common mean using data from several independent but nonhomogeneous populations. For point estimation, they propose a maximum empirical likelihood (MEL) estimator and show that it is n‐consistent and asymptotically optimal. For confidence intervals, they consider two EL based methods and show that both intervals have approximately correct coverage probabilities under large samples. Finite‐sample performances of the MEL estimator and the EL based confidence intervals are evaluated through a simulation study. The results indicate that overall the MEL estimator and the weighted EL confidence interval are superior alternatives to the existing methods.     

Block empirical likelihood for longitudinal partially linear regression models

The authors propose a block empirical likelihood procedure to accommodate the within‐group correlation in longitudinal partially linear regression models. This leads them to prove a nonparametric version of the Wilks theorem. In comparison with normal approximations, their method does not require a consistent estimator for the asymptotic covariance matrix, which makes it easier to conduct inference on the parametric component of the model. An application to a longitudinal study on fluctuations of progesterone level in a menstrual cycle is used to illustrate the procedure developed here.     

Confidence Intervals Based on Local Linear Smoother

Point-wise confidence intervals for a non-parametric regression function in conjunction with the popular local linear smoother are considered. The confidence intervals are based on the asymptotic normal distribution of the local linear smoother. Their coverage accuracy is evaluated by developing Edgeworth expansion for the coverage probability. It is found that the coverage error near the boundary of the support of the regression function is of a larger order than that in the interior, which implies that the local linear smoother is not adaptive to the boundary in terms of coverage. This is quite unexpected as the local linear smoother is adaptive to the boundary in terms of the mean squared error.     

Comparing and testing order relations between percentile residual life functions

We consider the problem of comparing and testing order relations between percentile residual life functions. We introduce R-R plots and processes and develop a general approach for this problem.     

Confidence bands from censored samples

Several types of asymptotic confidence bands have been proposed in the literature when the data are randomly censored on the right. Introducing new classes of bands, we place the old bands and their relationship to one another within a comprehensive theory of bands. A thorough analysis yields narrower bands and two kinds of modifications which are asymptotically distribution- and censor-free. One of these is useful when the interval on which the bands are constructed is predetermined and the width of the bands is random; the other, when there is a predetermined bound on the width and the interval is random. We illustrate our bands on the Szeged pacemaker data. These methods also provide a general modification of the Kolmogorov band in the uncensored case.     

Nonparametric estimation of the limiting availability

The point availability of a repairable system is the probability that the system is operating at a specified time. As time increases, the point availability converges to a positive constant called the limiting availability. Baxter and Li (1994a) developed a technique for constructing nonparametric confidence intervals for the point availability. However, nonparametric estimators of the limiting availability have not previously been studied in the literature. In this paper, we consider two separate cases: (1) the data are complete and (2) the data are subject to right censorship. For each case, a nonparametric confidence interval for the limiting availability is derived. Applications and simulation studies are presented.deceased after the paper was accepted     

Nonparametric estimation of discrete hazard functions

A smoothing procedure for discrete time failure data is proposed which allows for the inclusion of covariates. This purely nonparametric method is based on discrete or continuous kernel smoothing techniques that gives a compromise between the data and smoothness. The method may be used as an exploratory tool to uncover the underlying structure or as an alternative to parametric methods when prediction is the primary objective. Confidence intervals are considered and alternative techniques of cross validation based choices of smoothing parameters are investigated.     

Asymptotic normality of the lengths of a class of nonparametric confidence intervals for a regression parameter

In the linear regression model, the asymptotic distributions of certain functions of confidence bounds of a class of confidence intervals for the regression parameter arc investigated. The class of confidence intervals we consider in this paper are based on the usual linear rank statistics (signed as well as unsigned). Under suitable assumptions, if the confidence intervals are based on the signed linear rank statistics, it is established that the lengths, properly normalized, of the confidence intervals converge in law to the standard normal distributions; if the confidence intervals arc based on the unsigned linear rank statistics, it is then proved that a linear function of the confidence bounds converges in law to a normal distribution.