Geometric Method and Generalized Linear Models. Two Opposite Multiparametric Approaches Illustrated on a Sample of Pituitary Adenomas

We used two statistical methods to identify prognostic factors: a log-linear model (logistic and COX regression, based on the notions of linearity and multiplicative relative risk), and the CORICO method (ICOnography of CORrelations) based on the geometric significance of the correlation coefficient. We applied the methods to two different situations (a "case-control study' and a "historical cohort'). We show that the geometric exploratory tool is particularly suited to the analysis of small samples with a large number of variables. It could save time when setting up new study protocols. In this instance, the geometric approach highlighted, without preconceived ideas, the potential role of multihormonality in the course of pituitary adenoma and the unexpected influence of the date of tumour excision on the risk attached to haemorrhage.     

企业的合约经济理论探索和统计检验

对企业本质的认识是微观经济学中的一个重要问题,其对中国的国企改革有着重要意义。本文中,我们对企业的合约本质进行了经济理论探索和统计检验,并突出关注企业的激励合约问题。     

司空图《诗品》篇天人合一思维模式的原型追溯

以原型的方法对司空图《诗品》天人合一思维模式进行了全面分析。指出司空图《诗品》的思维模式遵循了中国古代由诗歌品阶、天时、时律、时历等形成的系统的天人合一模式，是典型的中国思维。     

价格不明合同合理价格的确定--新合同法第62条之不足与补救办法

对于价格不明合同的价格确定问题,我国新合同法和各国民商法的规定,在许多情况下无法适用,出现了立法上的缺漏,造成了实务上的无法可依,建议对新合同法第62条作三点补充解释1.没有相同产品的,可依争议产品之同类产品或者近似产品在合同订立时履行地市场类似交易中的正常销售价为可比价,确定争议产品的公平价格;2.争议产品之同类产品,在合同订立时的履行地市场未曾销售或者虽有销售,但销售数量、价格,不能作为公平价格进行比较的,可依该同类产品在适当的其他地区正常销售时的可比价格确定争议产品的公平价格;3.如果上述规定均不宜适用,可以争议产品之同类产品或者争议产品本身的生产成本加税费、合理利润和其他费用之和为其公平价格.     

素质拓展探索——建立数学教学新模式

本文简述建立数学教学新模式的必要性;论述了知识、能力、品质、方法之间的辨证关 系;提出了“知识、能力、品质”相结合的教学模式和一定的方法。     

Statistical Analyses and Modelling of the Mixing Process of Euro Coins in Germany and Europe

This paper reports on the mixing of Euro coins from different countries of origin in Europe, which started on 1 January 2002. There is an interesting conclusion: that the mobility of small and large denominations is different. The long‐term behaviour of the mixing process is studied using a simple deterministic model and data from Germany, France and the Netherlands. The analysis leads to predictions about the future progress of the mixing process.     

高师技法课改革的专业特殊性与科学性

本文从高师技法课(声乐、钢琴)教学改革的大潮中,提出了教学改革中应注意专业的特殊性和科学性,阐述了教学改革应遵循的基本原则以及合理的课型模式。     

Estimation of Metabolic Rate Constants in PBPK‐Models from Liver Slice Experiments: What Are the Experimental Needs?

A mechanistic model is presented describing the clearance of a compound in a precision-cut liver slice that is incubated in a culture medium. The problem of estimating metabolic rate constants in PBPK models from liver slice experiments is discussed using identifiability analysis. From the identifiability problem analysis, it appears that in addition to the clearance, the compound's free fraction in the slice and the diffusion rate of the exchange of the compound between culture medium and liver slice should be identified. In addition, knowledge of the culture medium volume, the slice volume, the compound's free fraction, and octanol-water-based partition between medium and slice is presupposed. The formal solution for identification is discussed from the perspective of experimental practice. A formally necessary condition for identification is the sampling of parent compound in liver slice or culture medium. However, due to experimental limitations and errors, sampling the parent compound in the slice together with additional sampling of metabolite pooled from the medium and the slice is required for identification in practice. Moreover, it appears that identification results are unreliable when the value of the intrinsic clearance exceeds the value of the diffusion coefficient, a condition to be verified a posteriori.     

MAS环境下实现Agent交互协作的关键技术

讨论了MAS环境下实现Agent交互协作的关键性问题。在分析Agent协同设计目标的基础上,将遗传算法应用于子任务的调度,提高了Agent协同工作的效率。应用Agent的通信语言建立了一个基于知识查询与操纵语言的Agent通信模型,通过引入Agent位置追踪和Agent消息缓存机制解决了Agent移动过程中遇到的位置追踪和通信失效问题。     

西方宪政的文化底蕴

踏入西方宪政的文化历程 ,追寻西方宪政的文化源头 ,解悟西方宪政的文化底蕴 :其中 ,基督教的性恶论是西方宪政的文化根基 ;社会契约的政治化是西方宪政文化的逻辑起点 ;人本主义的崛起是西方宪政的文化内核 ;法治传统的近代转型是宪政理想的实证标志。