On Modeling Wood Formation Using Parametric and Semiparametric Regressions for Count Data

Understanding how wood develops has become an important problematic of plant sciences. However, studying wood formation requires the acquisition of count data difficult to interpret. Here, the annual wood formation dynamics of a conifer tree species were modeled using generalized linear and additive models (GLM and GAM); GAM for location, scale, and shape (GAMLSS); a discrete semiparametric kernel regression for count data. The performance of models is evaluated using bootstrap methods. GLM was useful to describe the wood formation general pattern but had a lack of fitting, while GAM, GAMLSS, and kernel regression had a higher sensibility to short-term variations.     

A general approximation to quantiles

For many continuous distributions, a closed-form expression for their quantiles does not exist. Numerical approximations for their quantiles are developed on a distribution-by-distribution basis. This work develops a general approximation for quantiles using the Taylor expansion. Our method only requires that the distribution has a continuous probability density function and its derivatives can be derived to a certain order (usually 3 or 4). We demonstrate our unified approach by approximating the quantiles of the normal, exponential, and chi-square distributions. The approximation works well for these distributions.     

Bayesian adaptive dose‐escalation designs for simultaneously estimating the optimal and maximum safe dose based on safety and efficacy

The main purpose of dose‐escalation trials is to identify the dose(s) that is/are safe and efficacious for further investigations in later studies. In this paper, we introduce dose‐escalation designs that incorporate both the dose‐limiting events and dose‐limiting toxicities (DLTs) and indicative responses of efficacy into the procedure. A flexible nonparametric model is used for modelling the continuous efficacy responses while a logistic model is used for the binary DLTs. Escalation decisions are based on the combination of the probabilities of DLTs and expected efficacy through a gain function. On the basis of this setup, we then introduce 2 types of Bayesian adaptive dose‐escalation strategies. The first type of procedures, called “single objective,” aims to identify and recommend a single dose, either the maximum tolerated dose, the highest dose that is considered as safe, or the optimal dose, a safe dose that gives optimum benefit risk. The second type, called “dual objective,” aims to jointly estimate both the maximum tolerated dose and the optimal dose accurately. The recommended doses obtained under these dose‐escalation procedures provide information about the safety and efficacy profile of the novel drug to facilitate later studies. We evaluate different strategies via simulations based on an example constructed from a real trial on patients with type 2 diabetes, and the use of stopping rules is assessed. We find that the nonparametric model estimates the efficacy responses well for different underlying true shapes. The dual‐objective designs give better results in terms of identifying the 2 real target doses compared to the single‐objective designs.     

侵权人不明的高楼落物侵权的法律规制

《侵权责任法》第87条对侵权人不明的高楼落物侵权责任的承担进行了规定,具有保障受害人得到补偿、统一司法实践、降低致害概率的积极意义。但是,该规定也存在许多不足之处,主要表现为不利于社会和谐、容易引发道德风险、预防功能不充分、适用前提不明确等,没有很好地解决高楼落物侵权所面临的困境。采取社会救济、高楼落物赔偿基金、保险赔偿等多种途径相结合的救济方式,行政法、刑法与《侵权责任法》相配合的惩罚制度,不仅可以使受害人得到及时的、充分的补偿,而且可以有效预防此类侵权损害的发生。     

Classical estimation of hazard rate and mean residual life functions of Pareto distribution

Abstract

In this paper we find the maximum likelihood estimates (MLEs) of hazard rate and mean residual life functions (MRLF) of Pareto distribution, their asymptotic non degenerate distribution, exact distribution and moments. We also discuss the uniformly minimum variance unbiased estimate (UMVUE) of hazard rate function and MRLF. Finally, two numerical examples with simulated data and real data set, are presented to illustrate the proposed estimates.     

Decomposition of Variance for Spatial Cox Processes

Abstract. Spatial Cox point processes is a natural framework for quantifying the various sources of variation governing the spatial distribution of rain forest trees. We introduce a general criterion for variance decomposition for spatial Cox processes and apply it to specific Cox process models with additive or log linear random intensity functions. We moreover consider a new and flexible class of pair correlation function models given in terms of normal variance mixture covariance functions. The proposed methodology is applied to point pattern data sets of locations of tropical rain forest trees.     

Least squares estimation of varying‐coefficient hazard regression with application to breast cancer dose‐intensity data

To enhance modeling flexibility, the authors propose a nonparametric hazard regression model, for which the ordinary and weighted least squares estimation and inference procedures are studied. The proposed model does not assume any parametric specifications on the covariate effects, which is suitable for exploring the nonlinear interactions between covariates, time and some exposure variable. The authors propose the local ordinary and weighted least squares estimators for the varying‐coefficient functions and establish the corresponding asymptotic normality properties. Simulation studies are conducted to empirically examine the finite‐sample performance of the new methods, and a real data example from a recent breast cancer study is used as an illustration. The Canadian Journal of Statistics 37: 659–674; 2009 © 2009 Statistical Society of Canada     

POWER FUNCTION FOR INVERSE GAUSSIAN REGRESSION MODELS

Inverse Gaussian regression models are useful for data where both the independent and dependent variable are nonnegative and the variance of the dependent variable depends on the independent variable. Zero intercept inverse Gaussian regression models are presented with nonconstant variance, constant ratio of variance to the mean and constant coefficient of variation. The power function for testing hypotheses about the slope is given for all of these models.     

Asymptotic expaxsioxs for the joint distribution of cirrelated hotellings t2 statlstics under normality

Let T² _i=z′_iS^?1z_i, i==,…k be correlated Hotelling's T² statistics under normality. where z=(z′_i,…,z′_k)′ and nS are independently distributed as N_kp((O,ρ?∑) and Wishart distribution W_p(∑, n), respectively. The purpose of this paper is to study the distribution function F(x₁,…,x_k) of (T² _i,…,T² _k) when n is large. First we derive an asymptotic expansion of the characteristic function of (T² _i,…,T² _k) up to the order n^?2. Next we give asymptotic expansions for (T² _i,…,T² _k) in two cases (i)ρ=I_k and (ii) k=2 by inverting the expanded characteristic function up to the orders n^?2 and n^?1, respectively. Our results can be applied to the distribution function of max (T² _i,…,T² _k) as a special case.     

局部均衡函数及其构造

研究了局部均衡函数,定义了改进的局部变权向量,提出了与之对应的状态局部变权向量和局部均衡函数,证明了两类函数是局部均衡函数;利用局部变权向量建立了企业信用评估模型,并通过实例说明了该理论是有效的和合理的.