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161.
Several colorectal cancer (CRC) screening models have been developed describing the progression of adenomas to CRC. Currently, there is increasing evidence that serrated lesions can also develop into CRC. It is not clear whether screening tests have the same test characteristics for serrated lesions as for adenomas, but lower sensitivities have been suggested. Models that ignore this type of colorectal lesions may provide overly optimistic predictions of the screen‐induced reduction in CRC incidence. To address this issue, we have developed the Adenoma and Serrated pathway to Colorectal CAncer (ASCCA) model that includes the adenoma‐carcinoma pathway and the serrated pathway to CRC as well as characteristics of colorectal lesions. The model structure and the calibration procedure are described in detail. Calibration resulted in 19 parameter sets for the adenoma‐carcinoma pathway and 13 for the serrated pathway that match the age‐ and sex‐specific adenoma and serrated lesion prevalence in the COlonoscopy versus COlonography Screening (COCOS) trial, Dutch CRC incidence and mortality rates, and a number of other intermediate outcomes concerning characteristics of colorectal lesions. As an example, we simulated outcomes for a biennial fecal immunochemical test screening program and a hypothetical one‐time colonoscopy screening program. Inclusion of the serrated pathway influenced the predicted effectiveness of screening when serrated lesions are associated with lower screening test sensitivity or when they are not removed. To our knowledge, this is the first model that explicitly includes the serrated pathway and characteristics of colorectal lesions. It is suitable for the evaluation of the (cost)effectiveness of potential screening strategies for CRC.  相似文献   
162.
旅游交通是旅游经济发展中重要的内容之一,通过对中国十大城市群城市旅游交通可达性、铁路交通流分布情况与旅游经济联系、总量和隶属度进行计算,借助Arcgis10.2对中国十大城市群交通空间流分布情况和旅游经济联系进行空间可视化处理,并对计算结果进行综合比较分析。研究发现:高铁使得中国十大城市群城市旅游交通可达性水平得到大幅提升,且交通流分布均衡。中国十大城市群城市可达性的提升给城市旅游经济带来了一定的积极影响。高铁网络下中国十大城市群旅游经济联系分布不均衡。  相似文献   
163.
This paper evaluates economic impacts arising from the introduction of high-speed rail (HSR) between Madrid and Barcelona. Using difference-in-differences estimation we estimate an average treatment effect for provinces with stops on the HSR line of 2.4% for economic output, 3.3% for numbers of firms, and 1.1% for labour productivity. We complement our DID results with a synthetic control analysis for Lleida and Tarragona, two provinces that we argue were assigned HSR stations largely due to their incidental location. We find that both the number of firms and labour productivity are substantially higher in these provinces than in their synthetic counterparts.  相似文献   
164.
In recent decades, accelerating processes of globalization and an increase in economic inequality in most of the world's countries have raised the question of the emergence of a new bourgeoisie integrated at the global level, sometimes described as a global super-bourgeoisie. This group would be distinguished by its unequaled level of wealth and global interconnectedness, its transnational ubiquity and concentration in the planet's major global cities, its specific culture, consumption habits, sites of sociability and shared references, and even by class consciousness and capacity to act collectively. This article successively discusses how the social sciences have examined these various dimensions of the question and begun to provide systematic empirical answers.  相似文献   
165.
知识产权"十二五"发展规划具有多重属性与复杂性、制定组织结构多元化、地区发展不平衡及其与环境匹配较难等特点,较薄弱的知识产权基础因素与国际发展动态影响下,使得我国知识产权"十二五"发展规划实施挑战与机遇并存。  相似文献   
166.
This article examines the effects of gender on the leadership of bilateral development aid agencies, particularly their official development assistance (ODA) allocations toward gender‐related programming. Drawing on earlier research on gendered leadership, the article tests the hypothesis that female director generals (DGs) and ministers responsible for aid agencies will allocate more ODA than their male counterparts toward gender programming. This existing literature on gendered leadership is divided: some scholars argue that women and men have distinct leadership styles on account of their gender, while others argue that the only distinguishing factor is the institutional context in which they lead. Drawing on data collected on aid flows and agency leadership within the major Western aid donors of the Organisation for Economic Co‐operation and Development (OECD) Development Assistance Committee (DAC) over the period from 1995 through 2009, we use pooled time series analysis to examine the effects of gendered leadership on aid allocation. Our analysis reveals a tendency for female DGs and ministers to focus ODA on gender‐mainstreaming programs, while male DGs focus ODA on gender‐focused programs. We argue that these divergent priorities reflect the women's desire to reform gendered power structures within their respective aid agencies, and the men's desire to maintain existing gender power structures from which they benefit.  相似文献   
167.
艾伦·伍德基于历史唯物主义对经济和政治的连续性的分析,以民主为切入点,借鉴古雅典经济民主和政治民主相统一的洞见,揭示了资本主义民主的虚假性。伍德的观点既有助于我们认识资本主义民主的本质,也有助于我们从经济民主和政治民主相统一的维度重新思考社会主义民主,建构社会主义民主制度。  相似文献   
168.
能够对现代社会产生长远影响的本源型传统,构成现代社会发展的基础性制度。在东方国家的本源型传统中,不同于俄国和印度的村社制,中国是家户制,并在此基础上形成独特的中国农村发展道路。其中包括:以家户经营为基础的农业经营组织,家户内部农工商结合基础上的农工商互补经济,家户互助合作基础上的农村合作形式,家国共治基础上的农村治理体系。在中国农村发展进程中,尽管家户制一度被抛弃,但仍构成当下及未来农村发展的制度底色。  相似文献   
169.
伴随着阶级和国家的产生,关于意识形态的争论从来没有停止过。意识形态之争的表象是话语权、信奉者和影响力、感召力的争夺;意识形态之争的根基源于意识形态的科学性、传播方式和经济基础;意识形态之争的实质归于阶级和国家利益的维护。当前,认清意识形态争论的表象、阐明意识形态争论的根基、揭示意识形态争论的本质对于我国主流意识形态的建设具有重要意义。  相似文献   
170.
地下钱庄并非规范的法律概念,我国对地下钱庄法律价值的判断是基于其组织的非正规性而非其行为的违法性,对地下钱庄行为更多地是借助刑法规制和执法严惩而非制度规范和监管指引。以刑法与经济法互动为视角,对地下钱庄所从事的三类主要业务进行具体分析,对相关法律法规予以细致梳理和客观评价,并结合我国金融生态环境和地下钱庄行为特点提出相应的立法建议和防控对策。提出在治理地下钱庄的过程中应当做到经济法规制在前、刑法惩治在后,监管在前、执法在后,宽严相济、疏堵结合。  相似文献   
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