A modified false discovery rate multiple-comparisons procedure for discrete data, applied to human immunodeficiency virus genetics

Summary.  To help to design vaccines for acquired immune deficiency syndrome that protect broadly against many genetic variants of the human immunodeficiency virus, the mutation rates at 118 positions in HIV amino-acid sequences of subtype C versus those of subtype B were compared. The false discovery rate (FDR) multiple-comparisons procedure can be used to determine statistical significance. When the test statistics have discrete distributions, the FDR procedure can be made more powerful by a simple modification. The paper develops a modified FDR procedure for discrete data and applies it to the human immunodeficiency virus data. The new procedure detects 15 positions with significantly different mutation rates compared with 11 that are detected by the original FDR method. Simulations delineate conditions under which the modified FDR procedure confers large gains in power over the original technique. In general FDR adjustment methods can be improved for discrete data by incorporating the modification proposed.     

Who Gets What From Government? Distributional Consequences of Child‐Care Assistance Policies

Given the fragmented structure of child‐care assistance in the United States, it has been difficult to obtain accurate estimates of which families are assisted, through which mechanisms, and at what level. Making use of survey data from New York City, we analyze the distribution of several forms of public child‐care assistance. Results suggest that about 40% of all families with young children receive some form of child‐care assistance. Considering all forms of assistance, the distribution of child‐care help is targeted in both expected and some unexpected ways. Implications of these results are discussed in the context of U.S. child‐care policies governing access and benefit levels.     

清初治滇述论

清朝初年,特别是平定“三藩之乱”后的二三十年间,是云南实现由乱到治的关键时期。清朝统治者在总结和借鉴历代治滇思想和治策的基础上,经过不断调整、充实,逐步形成了一套相对完整的治滇治策体系,其治策涉及云南的政治、经济、文化等领域,较为切合当时社会发展的实际,成为其后清朝统治云南的治边思想和治策。     

东盟政策机制中的政策网络

政策网络是政策机制的重要组成部分,东盟政策网络的结构和运作是其政治精英理性选择的结果,目的是使这个地区政策网络能满足一体化政策领域扩展的需要,并实现区域一体化进程中各成员国的利益最大化。     

Role of informal sector recycling in waste management in developing countries

Many thousands of people in developing country cities depend on recycling materials from waste for their livelihoods. With the focus of the Millennium Development Goals on poverty reduction, and of waste strategies on improving recycling rates, one of the major challenges in solid waste management in developing countries is how best to work with this informal sector to improve their livelihoods, working conditions and efficiency in recycling.The general characteristics of informal recycling are reviewed, highlighting both positive and negative aspects. Despite the health and social problems associated with informal recycling, it provides significant economic benefits that need to be retained. Experience shows that it can be highly counterproductive to establish new formal waste recycling systems without taking into account informal systems that already exist. The preferred option is to integrate the informal sector into waste management planning, building on their practices and experience, while working to improve efficiency and the living and working conditions of those involved. Issues associated with integrating informal recycling into the formal waste management sector are discussed.     

台湾的金融改革及其启示

要本文在分析台湾实行金融改革动因的基础上，概述了台湾金融改革的内容，评述了台湾实行金融自由化的目的－建立区域金融中心的构想，并就这一改革给大陆带来的启示作出了思考。     

公益林补偿政策评价研究

论述了公益林补偿政策评价研究的现状,分析了补偿政策评价的特点和存在问题,提出了解决问题的对策,并借鉴了美国联邦政府项目评价体系,提出了补偿政策的定性评价内容。     

论以土地承包经营权抵押为特征的金融制度

在我国建立以土地承包经营权为抵押的农村金融制度具有重要的现实意义 ,它能促进农地资源有效利用 ,提高农地利用的效益。目前世界上许多国家都建立了自己的农地抵押金融制度。根据我国实际情况 ,应消除现有法律上的障碍 ,设立类似于外国土地银行的政策性银行 ,主管我国的土地承包经营权抵押贷款金融制度 ,但在具体的抵押权规定方面 ,如对土地附着物的效力及抵押权实现方面应与一般抵押权制度相区别。     

When the Export of Social Problems Is No Longer Possible: Immigration Policies and Unemployment in Switzerland

Throughout the twentieth century, Switzerland has been one of the OECD countries with the highest proportion of immigrants in its population. The aim of this article is to show how institutional factors have shaped the opportunities for change in immigration and immigrant‐employment‐related policies there in the 1990s. Whereas unemployment had remained low in the 1970s and 1980s, there was a marked increase at the beginning of the 1990s. Existing migration policies were considered a central cause of this increase, since the great majority of foreigners who had come and settled in Switzerland in the periods of economic expansion were low‐skilled, and were now over‐represented among the unemployed. The reforms undertaken in the field of immigration and integration policy to respond to these new problems have been determined by specific institutional factors: direct democracy, a defensive migration regime, the development of immigrant rights and the weak autonomy of the central state. These factors account to a large extent for the limited scope and specific pathways of policy reforms in these two domains.     

浅析我国当前的失业问题

我国当前的失业问题，其核心因素是供需双方的知识结构偏离，人力资源政策是解决失业问题的关键措施。