我国深化素质教育改革的主要对策

目前我国素质教育改革的重点应是尽快启动素质教育评价体系建设国家研究项目,积极推进高校招生制度改革,促进学生身心协调健康成长,加快推进中小学实施小班化教学和加强农村师资建设。力争在较短的时间内实现高等教育质量的根本性恢复,稳步推进教育管理体制改革为素质教育改革目标的实现提供制度环境支持。     

A Bayesian Adjustment for Covariate Misclassification with Correlated Binary Outcome Data

Estimated associations between an outcome variable and misclassified covariates tend to be biased when the methods of estimation that ignore the classification error are applied. Available methods to account for misclassification often require the use of a validation sample (i.e. a gold standard). In practice, however, such a gold standard may be unavailable or impractical. We propose a Bayesian approach to adjust for misclassification in a binary covariate in the random effect logistic model when a gold standard is not available. This Markov Chain Monte Carlo (MCMC) approach uses two imperfect measures of a dichotomous exposure under the assumptions of conditional independence and non-differential misclassification. A simulated numerical example and a real clinical example are given to illustrate the proposed approach. Our results suggest that the estimated log odds of inpatient care and the corresponding standard deviation are much larger in our proposed method compared with the models ignoring misclassification. Ignoring misclassification produces downwardly biased estimates and underestimate uncertainty.     

唐宋变革论体系的演化

自近代以来，由日本学者构筑的唐宋变革论体系，伴随时代的发展与新的知识资源的扩充，呈现出不断发展变化的趋势。本文旨在揭示这一演化的历史过程，尝试着分析这一过程变动发展的原因，并由此作出区别于以往的评价。     

论语篇体裁理论在英语写作教学中的应用

本文以系统功能语言学的语篇体载理论为依托，对该理论在大学英语写作教学中的应用进行了探讨。教师在写作教学实践中可以从引导学生挖掘不同语篇体裁的交际目的和社会文化背景入手，指导学生从宏观角度有效把握不同语篇体裁的概括性结构定武，鼓励学生逐步改进思维方式，从而全面提高写作能力。     

有效词汇教学探讨

这篇论文旨在解决英语词汇教学方面的问题。在分析学生词汇习得的基础上和对教学法的回顾和讨论的基础上,论文得出了一些可考的观点。     

Examples of the use of an equivalence theorem in constructing optimum experimental designs for random-effects nonlinear regression models

The problem considered is that of finding an optimum measurement schedule to estimate population parameters in a nonlinear model when the patient effects are random. The paper presents examples of the use of sensitivity functions, derived from the General Equivalence Theorem for D-optimality, in the construction of optimum population designs for such schedules. With independent observations, the theorem applies to the potential inclusion of a single observation. However, in population designs the observations are correlated and the theorem applies to the inclusion of an additional measurement schedule. In one example, three groups of patients of differing size are subject to distinct schedules. Numerical, as opposed to analytical, calculation of the sensitivity function is advocated. The required covariances of the observations are found by simulation.     

也谈"错案追究制"

错案追究制自运行以来存在着许多问题,其所具有的负面影响超过了其积极效应的一面.本文从多角度分析了错案追究制产生的影响,并对错案进行了科学的界定.在此基础上,本文倡导错案追究制应让位于全面的司法改革,并提出了具体的司法改革措施.     

中日文化差异与日语教学

中日两国一衣带水,相互毗邻,有着两千多年的友好交往历史。在语言文字方面两国人民互相学习,相互影响,有不少相同、相似之处。但其中也有一些看似相同,实际上已经出现差异并具有特色的词汇和习俗,弄清这些词汇和习俗差异对我们学习日语和同日本人交流大有益处。尤其是在日语教学中,把这些词汇与习俗的异同及时渗透给学生,把中日文化的对比融入日语语言教学中,既可大大地活跃课堂气氛,又可提高学生的积极性和交际水平、应用能力。     

Non-ignorable missing covariate data in survival analysis: a case-study of an International Breast Cancer Study Group trial

Summary.  Non-ignorable missing data, a serious problem in both clinical trials and observational studies, can lead to biased inferences. Quality-of-life measures have become increasingly popular in clinical trials. However, these measures are often incompletely observed, and investigators may suspect that missing quality-of-life data are likely to be non-ignorable. Although several recent references have addressed missing covariates in survival analysis, they all required the assumption that missingness is at random or that all covariates are discrete. We present a method for estimating the parameters in the Cox proportional hazards model when missing covariates may be non-ignorable and continuous or discrete. Our method is useful in reducing the bias and improving efficiency in the presence of missing data. The methodology clearly specifies assumptions about the missing data mechanism and, through sensitivity analysis, helps investigators to understand the potential effect of missing data on study results.     

Statistical and Combinatorial Aspects of Comparative Genomics*

Abstract. This document presents a survey of the statistical and combinatorial aspects of four areas of comparative genomics: gene order based measures of evolutionary distances between species, construction of phylogenetic trees, detection of horizontal transfer of genes, and detection of ancient whole genome duplications.