Case–control genome-wide joint association study using semiparametric empirical model and approximate Bayes factor

We propose a semiparametric approach for the analysis of case–control genome-wide association study. Parametric components are used to model both the conditional distribution of the case status given the covariates and the distribution of genotype counts, whereas the distribution of the covariates are modelled nonparametrically. This yields a direct and joint modelling of the case status, covariates and genotype counts, and gives a better understanding of the disease mechanism and results in more reliable conclusions. Side information, such as the disease prevalence, can be conveniently incorporated into the model by an empirical likelihood approach and leads to more efficient estimates and a powerful test in the detection of disease-associated SNPs. Profiling is used to eliminate a nuisance nonparametric component, and the resulting profile empirical likelihood estimates are shown to be consistent and asymptotically normal. For the hypothesis test on disease association, we apply the approximate Bayes factor (ABF) which is computationally simple and most desirable in genome-wide association studies where hundreds of thousands to a million genetic markers are tested. We treat the approximate Bayes factor as a hybrid Bayes factor which replaces the full data by the maximum likelihood estimates of the parameters of interest in the full model and derive it under a general setting. The deviation from Hardy–Weinberg Equilibrium (HWE) is also taken into account and the ABF for HWE using cases is shown to provide evidence of association between a disease and a genetic marker. Simulation studies and an application are further provided to illustrate the utility of the proposed methodology.     

A Practical Implementation and Bayesian Estimation in Franklin's Randomized Response Procedure

A Bayesian estimator based on Franklin's randomized response procedure is proposed for proportion estimation in surveys dealing with a sensitive character. The method is simple to implement and avoids the usual drawbacks of Franklin's estimator, i.e., the occurrence of negative estimates when the population proportion is small. A simulation study is considered in order to assess the performance of the proposed estimator as well as the corresponding credible interval.     

An Adaptive Test for the Two-Sample Location Problem Based on U-Statistics

For the two-sample location problem with continuous data we consider a general class of tests, all members of it are based on U-statistics. The asymptotic efficacies are investigated in detail. We construct an adaptive test where all statistics involved are suitably chosen U-statistics. It is shown that the proposed adaptive test has good asymptotic and finite sample power properties.     

Reliability Properties of Systems with Two Exchangeable Log-Logistic Components

In this article, we study the reliability properties of systems under bivariate log-logistic model which comes out from a particular stress-strength analysis. For this model, we obtain basic reliability characteristics of series and parallel systems and investigate their properties. We also derive distribution and moments of cold standby system under the abovementioned exchangeable model.     

On the quantile past lifetime of the components of the parallel systems

ABSTRACT

Let T_{1: n} ? T_{2: n} ? ??? ? T_{n: n} be ordered lifetimes of components of a parallel system. In this article, the α-quantile past lifetime from the failure of the component with lifetime T_{r: n} provided that the system has failed at or before time t has been introduced. Then, some properties of this measure have been studied.     

ML and Bayes estimation in a two-phase tandem queue with a second optional service and random feedback

ABSTRACT

In this article, we consider a two-phase tandem queueing model with a second optional service and random feedback. The first phase of service is essential for all customers and after the completion of the first phase of service, any customer receives the second phase of service with probability α, feedback to the tail of the first queue with probability β if the service is not successful and leaves the system with probability 1 ? α ? β. In this model, our main purpose is to estimate the parameters of the model, traffic intensity, and mean system size, in the steady state, via maximum likelihood and Bayesian methods. Furthermore, we find asymptotic confidence intervals for mean system size. Finally, by a simulation study, we compute the confidence levels and mean length for asymptotic confidence intervals of mean system size with a nominal level 0.95.     

Use of several auxiliary variables in estimating the population mean in a two-occasion rotation pattern

ABSTRACT

This paper addresses the problem of estimation of the population mean on the current (second) occasion in two-occasion successive sampling. Utilizing the readily available information on several auxiliary variables on both occasions and the information on the study variable from the previous occasion, an estimation procedure of the population mean on the current occasion has been proposed. Theoretical properties of the proposed estimator have been investigated. Optimum replacement policy to the proposed estimator has been discussed. The proposed estimator has been compared empirically with the sample mean estimator, when there is no matching and the optimum estimator which is a linear combination of the means of the matched and unmatched portions of the sample at the current occasion. Appropriate recommendations have been made for practical applications.     

Sequential order statistics from dependent random variables

Abstract

This paper provides an extension for “sequential order statistics” (SOS) introduced by Kamps. It is called “developed sequential order statistics” (DSOS) and is useful for describing lifetimes of engineering systems when component lifetimes are dependent. Explicit expressions for the joint density function, the marginal distributions and the means of DSOS are derived. Under the well known “conditional proportional hazard rate” (CPHR) model and the Gumbel families of copulas for dependency among component lifetimes, some findings are reported. For example, it is proved that the joint density functions of DSOS and SOS have the same structure. Various illustrative examples are also given.     

An improved comorbidity summary score for measuring disease burden and predicting mortality with applications to two national cohorts

Abstract

Research involving administrative healthcare data to study patient outcomes requires the investigator to account for the patient’s disease burden in order to reduce the potential for biased results. Here we develop a comorbidity summary score based on variable importance measures derived from several statistical and machine learning methods and show it has superior predictive performance to the Elixhauser and Charlson indices when used to predict 1-year, 5-year, and 10-year mortality. We used two large Veterans Administration cohorts to develop and validate the summary score and compared predictive performance using the area under ROC curve (AUC) and the Brier score.