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991.
992.
Service operations that utilize cross-trained employees face complex workforce staffing decisions that have important implications for both cost and productivity. These decisions are further complicated when cross-trained employees have different productivity levels in multiple work activity categories. A method for policy analysis in such environments can be beneficial in determining low-cost staffing plans with appropriate cross-training configurations. In this paper, we present an integer linear programming model for evaluating cross-training configurations at the policy level. The objective of the model is to minimize workforce staffing costs subject to the satisfaction of minimum labor requirements across a planning horizon of a single work shift. The model was used to evaluate eight cross-training structures (consisting of 36 unique cross-training configurations) across 512 labor requirement patterns. These structures, as well as the labor requirement patterns, were established based on data collected from maintenance operations at a large paper mill in the United States. The results indicate that asymmetric cross-training structures that permit chaining of employee skill classes across work activity categories are particularly useful.  相似文献   
993.
新媒体已经成为审视与研究思想政治教育的重要场域,处于思想政治教育理论研究与实践工作中的前沿.自21世纪初,新媒体受到思想政治教育学界的关注以来,人们对其的认识有冲击论、工具论到环境论三种观点,且形成了三种观点并存的局面,在研究中广泛运用了传播学、社会治理等理论资源.但受限于对新媒体、思想政治教育的传统认知,思想政治教育新媒体研究仍然存在着研究思维、研究视野、研究方法以及研究观点的局限.新媒体实现了媒介、信息以及互动交流前所未有的融合,其所引发的不仅是交往方式的变化,而且是意识形态传播机制的变化.进一步拓深思想政治教育新媒体研究,应结合马克思的交往理论、政治传播理论以及我国特有的政治文化传统,实现对新媒体思想政治教育意义的跨学科解读.  相似文献   
994.
In this paper we define a class of unbalanced designs, denoted by Ck,s,t, for estimating the components of variance in a k-stage nested random effects linear model. This class contains many of the designs proposed in the literature for nested components of variance models. We focus on the three-state model and discuss the determination of locally optimal designs within this class using a systematic computer search. For large sample sizes we show that approximate optimal designs may be obtained using a limit argument combined with numerical optimization. A comparison of our designs with previously published designs suggests that, in many cases, our designs result in substantial gains in efficiency.  相似文献   
995.
In this paper we present an approach to using historical control data to augment information from a randomized controlled clinical trial, when it is not possible to continue the control regimen to obtain the most reliable and valid assessment of long term treatment effects. Using an adjustment procedure to the historical control data, we investigate a method of estimating the long term survival function for the clinical trial control group and for evaluating the long term treatment effect. The suggested method is simple to interpret, and particularly motivated in clinical trial settings when ethical considerations preclude the long term follow-up of placebo controls. A simulation study reveals that the bias in parameter estimates that arises in the setting of group sequential monitoring will be attenuated when long term historical control information is used in the proposed manner. Data from the first and second National Wilms' Tumor studies are used to illustrate the method.  相似文献   
996.
Two indices of creatinine clearance (an index of kidney function) are compared on a group of cancer patients who underwent chemotherapy with a potentially nephrotoxic drug. The standard index, measured creatinine clearance MCC, is cumbersome to use, whereas the more convenient alternative, estimated creatinine clearance ECC, has not yet been conclusively evaluated on cancer patients. We conclude that under certain clinical conditions ECC and MCC are identically calibrated for males, but not for females, and we obtain estimated true and false positive rates for assessing the use of ECC instead of MCC as a diagnostic tool. We use a model that is formally equivalent to an errors-in-variables model with (unbalanced) repeated observations and correlated measurement errors. The bootstrap is used to obtain standard errors and confidence limits.  相似文献   
997.
For frequency counts, the situation of extra zeros often arises in biomedical applications. This is demonstrated with count data from a dental epidemiological study in Belo Horizonte (the Belo Horizonte caries prevention study) which evaluated various programmes for reducing caries. Extra zeros, however, violate the variance–mean relationship of the Poisson error structure. This extra-Poisson variation can easily be explained by a special mixture model, the zero-inflated Poisson (ZIP) model. On the basis of the ZIP model, a graphical device is presented which not only summarizes the mixing distribution but also provides visual information about the overall mean. This device can be exploited to evaluate and compare various groups. Ways are discussed to include covariates and to develop an extension of the conventional Poisson regression. Finally, a method to evaluate intervention effects on the basis of the ZIP regression model is described and applied to the data of the Belo Horizonte caries prevention study.  相似文献   
998.
The paper examines the homogeneity of a pair of straight lines, regarded as the expected values of two different linear regressions, from an equivalence point of view. This seems more appropriate than the usual testing of the null hypothesis of homogeneity when the aim is to establish that the lines are close to homogeneous. Upper confidence bounds on the maximum difference between the lines are based on the usual least squares regression estimators, assuming normal distributions. These bounds are constructed for fixed points, or over a fixed interval, and it is concluded that the lines are 1-homogeneous if the bounds are not greater than 1: Also, intervals are constructed over which the lines are concluded to be 1-homogeneous.  相似文献   
999.
This paper characterizes the family of Normal distributions within the class of exponential families of distributions, via the structure of the bias of the maximum likelihood estimator Θ n of the canonical parameter Θ . More specifically, when E θ ( Θ n ) – Θ = (1/ n ) Q ( Θ ) + o (1/ n ), the equality Q ( Θ ) = 0 proves to be a property of the Normal distribution only. The same conclusion is obtained for the one-dimensional case bt assuming that Q ( Θ ) is a polynomial of Θ .  相似文献   
1000.
In this investigation a test of goodness of fit for exponentiality is proposed. This procedure applies equally whether the scale and/or the location parameters of the distribution are known or not. The limiting null and non-null distributions of the test statistic are normal under minimal conditions. Monte Carlo critical values for small sample sizes are given and the power of the test is calculated for various alternatives showing that it compares favourably relatively to other more complicated published procedures.  相似文献   
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