Development of Ego‐resiliency: Relations to Observed Parenting and Polymorphisms in the Serotonin Transporter Gene During Early Childhood

We used observed parenting behaviors, along with genetic variants and haplotypes of the serotonin transporter gene (SLC6A4), as predictors of children's ego‐resiliency during early childhood (N = 153). The quality of mothers' parenting was observed at 18 months of age, and mothers' reports of ego‐resiliency were collected at six time points from 18 to 84 months. Genetic data were collected at 72 months. Observed parenting was positively associated with initial levels of children's ego‐resiliency. Furthermore, although individual genetic variants of the serotonin transporter gene (LPR, STin2) were not associated with ego‐resiliency, the S10 haplotype (that combines information from these two variants) was negatively associated with initial levels of ego‐resiliency. Both parenting and serotonin genetic variation uniquely predicted children's ego‐resiliency, suggesting an additive effect of genetic and parental factors.     

《苏珊娜传》与《窦娥冤》中的神判母题比较研究

《苏珊娜传》和《窦娥冤》情节结构相似,而且都包含了神判母题,针对同一母题在不同文化中的表现方式及由此造成的不同的美学风格的分析,进一步探索这一母题在不同文化中的原型意义;同时,对人类不同民族的共同心理的思考贯穿全文:神判思想在各民族文化的普遍存在表现了人类时自身能力局限性的认识,对超自然力量的敬畏以及对公正和谐的理想社会的渴望。     

论中国自然辩证法学派传统与特色

研究传统是学派存在和发展的基因。中国自然辩证法学派形成了自己独特的研究传统,它包括以人工自然为核心的本体论、以唯物辩证法为核心方法论和以服务中国社会主义建设为核心的价值论。相对稳定的逻辑结构、巨大包容的学术能力、实事求是的科学精神、不断开拓的研究领域是这个学派的学术风范和中国特色。     

AMMI模型在玉米区域试验中的应用

运用AMMI模型对四川省玉米区试平丘B组 1998～ 1999两年试验数据进行了分析。结果表明 :①AMMI模型能具体、直观、灵敏地综合评价玉米大区区域试验参试品种的稳定性。②两年参试的玉米品种中绵 786× 12 11、品 95- 2具有优良的丰产性、稳定性和广泛的适应性     

Inferring gene regulatory networks by an order independent algorithm using incomplete data sets

Analyzing incomplete data for inferring the structure of gene regulatory networks (GRNs) is a challenging task in bioinformatic. Bayesian network can be successfully used in this field. k-nearest neighbor, singular value decomposition (SVD)-based and multiple imputation by chained equations are three fundamental imputation methods to deal with missing values. Path consistency (PC) algorithm based on conditional mutual information (PCA–CMI) is a famous algorithm for inferring GRNs. This algorithm needs the data set to be complete. However, the problem is that PCA–CMI is not a stable algorithm and when applied on permuted gene orders, different networks are obtained. We propose an order independent algorithm, PCA–CMI–OI, for inferring GRNs. After imputation of missing data, the performances of PCA–CMI and PCA–CMI–OI are compared. Results show that networks constructed from data imputed by the SVD-based method and PCA–CMI–OI algorithm outperform other imputation methods and PCA–CMI. An undirected or partially directed network is resulted by PC-based algorithms. Mutual information test (MIT) score, which can deal with discrete data, is one of the famous methods for directing the edges of resulted networks. We also propose a new score, ConMIT, which is appropriate for analyzing continuous data. Results shows that the precision of directing the edges of skeleton is improved by applying the ConMIT score.     

压力性尿失禁的遗传相关因素

压力性尿失禁是一种常见的、遗传的和多向的下尿路障碍，是医学研究的国际热点。基因型和表现型之间的关系是复杂的，而且易受环境影响。基因的变异会增加压力性尿失禁的患病风险，如胶原蛋白I A 1、5-羟色胺2A等基因的多态性。但相关基因的研究并不多，不够深入，本文就目前已有研究做一个综述。     

基因诊断与治疗方法的可专利性研究

随着人类基因组计划的完成,基因诊断和治疗方法作为新一代的生物医疗技术备受关注。基因诊断和治疗是生物技术发展中的一个热门产业,是否对基因诊断和治疗方法授予专利权这个问题引起各国的广泛关注和讨论。主要介绍美、欧、日三大专利局对基因诊断和治疗方法是否具有可专利性的做法,阐述支持和反对基因诊断和治疗方法授予专利权的原因,提出相关的完善意见。     

线粒体与胰岛素抵抗和糖尿病关系的研究进展

2型糖尿病以胰岛素抵抗为病理基础。虽然膳食、生活方式等环境因素仍被认为是糖尿病的发病中的重要决定因素,但是糖尿病具有明显的家族遗传学基础,而线粒体基因组某些位点的点突变、缺失突变和重复突变均被证明与糖尿病发生密切相关。     

境遇中的新基因伦理学探析

为摆脱传统基因伦理学的解释学困境,突破其理论局限与实践局限,可以从现象学出发,借助海德格尔的存在论哲学、梅洛庞蒂的身体现象学、维贝克的道德物化理论等,以境遇的有限性和发生性作为理论突破口,在技术调解无效的情况下,通过“协商陪审”机制,实现新基因伦理学的社会有效性。     

病情史料发掘与沈从文再认识

沈从文的家族存在着强大的“疯狂”遗传基因,这使得沈从文的感知方式呈现出一定的“异常性”,并对其文学活动、精神流变与生命创建产生了深远的影响。20世纪40年代中期,沈从文文学创作风格发生了较大的转变,出现了诸如《看虹录》《绿魇》《莲花》之类的“悦乐疯狂”之作,并产生了“神”、“生命”等超逻辑的思想命题,与这一时期他病情的加剧有着密切的关系。