Marginal zero-inflated regression models for count data

Data sets with excess zeroes are frequently analyzed in many disciplines. A common framework used to analyze such data is the zero-inflated (ZI) regression model. It mixes a degenerate distribution with point mass at zero with a non-degenerate distribution. The estimates from ZI models quantify the effects of covariates on the means of latent random variables, which are often not the quantities of primary interest. Recently, marginal zero-inflated Poisson (MZIP; Long et al. [A marginalized zero-inflated Poisson regression model with overall exposure effects. Stat. Med. 33 (2014), pp. 5151–5165]) and negative binomial (MZINB; Preisser et al., 2016) models have been introduced that model the mean response directly. These models yield covariate effects that have simple interpretations that are, for many applications, more appealing than those available from ZI regression. This paper outlines a general framework for marginal zero-inflated models where the latent distribution is a member of the exponential dispersion family, focusing on common distributions for count data. In particular, our discussion includes the marginal zero-inflated binomial (MZIB) model, which has not been discussed previously. The details of maximum likelihood estimation via the EM algorithm are presented and the properties of the estimators as well as Wald and likelihood ratio-based inference are examined via simulation. Two examples presented illustrate the advantages of MZIP, MZINB, and MZIB models for practical data analysis.     

Multivariate Return Decomposition: Theory and Implications

In this paper, we propose a model based on multivariate decomposition of multiplicative – absolute values and signs – components of asset returns. In the m-variate case, the marginals for the m absolute values and the binary marginals for the m directions are linked through a 2m-dimensional copula. The approach is detailed in the case of a bivariate decomposition. We outline the construction of the likelihood function and the computation of different conditional measures. The finite-sample properties of the maximum likelihood estimator are assessed by simulation. An application to predicting bond returns illustrates the usefulness of the proposed method.     

Conditional covariance penalties for mixed models

The prediction error for mixed models can have a conditional or a marginal perspective depending on the research focus. We introduce a novel conditional version of the optimism theorem for mixed models linking the conditional prediction error to covariance penalties for mixed models. Different possibilities for estimating these conditional covariance penalties are introduced. These are bootstrap methods, cross-validation, and a direct approach called Steinian. The behavior of the different estimation techniques is assessed in a simulation study for the binomial-, the t-, and the gamma distribution and for different kinds of prediction error. Furthermore, the impact of the estimation techniques on the prediction error is discussed based on an application to undernutrition in Zambia.     

Bootstrapping Periodic State-Space Models

This article is concerned with how the bootstrap can be applied to study conditional forecast error distributions and construct prediction regions for future observations in periodic time-varying state-space models. We derive, first, an algorithm for assessing the precision of quasi-maximum likelihood estimates of the parameters. As a result, the derived algorithm is exploited for numerically evaluating the conditional forecast accuracy of a periodic time series model expressed in state space form. We propose a method which requires the backward, or reverse-time, representation of the model for assessing conditional forecast errors. Finally, the small sample properties of the proposed procedures will be investigated by some simulation studies. Furthermore, we illustrate the results by applying the proposed method to a real time series.     

Joint models for mixed categorical outcomes: a study of HIV risk perception and disease status in Mozambique

Two types of bivariate models for categorical response variables are introduced to deal with special categories such as ‘unsure’ or ‘unknown’ in combination with other ordinal categories, while taking additional hierarchical data structures into account. The latter is achieved by the use of different covariance structures for a trivariate random effect. The models are applied to data from the INSIDA survey, where interest goes to the effect of covariates on the association between HIV risk perception (quadrinomial with an ‘unknown risk’ category) and HIV infection status (binary). The final model combines continuation-ratio with cumulative link logits for the risk perception, together with partly correlated and partly shared trivariate random effects for the household level. The results indicate that only age has a significant effect on the association between HIV risk perception and infection status. The proposed models may be useful in various fields of application such as social and biomedical sciences, epidemiology and public health.     

Joint Modelling of Survival and Longitudinal Data with Informative Observation Times

In this paper, we consider the joint modelling of survival and longitudinal data with informative observation time points. The survival model and the longitudinal model are linked via random effects, for which no distribution assumption is required under our estimation approach. The estimator is shown to be consistent and asymptotically normal. The proposed estimator and its estimated covariance matrix can be easily calculated. Simulation studies and an application to a primary biliary cirrhosis study are also provided.     

Mixtures of regression models with incomplete and noisy data

The estimation of the mixtures of regression models is usually based on the normal assumption of components and maximum likelihood estimation of the normal components is sensitive to noise, outliers, or high-leverage points. Missing values are inevitable in many situations and parameter estimates could be biased if the missing values are not handled properly. In this article, we propose the mixtures of regression models for contaminated incomplete heterogeneous data. The proposed models provide robust estimates of regression coefficients varying across latent subgroups even under the presence of missing values. The methodology is illustrated through simulation studies and a real data analysis.     

A class of partially linear transformation models for recurrent gap times

In this article, we propose a general class of partially linear transformation models for recurrent gap time data, which extends the linear transformation models by incorporating non linear covariate effects and includes the partially linear proportional hazards and the partially linear proportional odds models as special cases. Both global and local estimating equations are developed to estimate the parametric and non parametric covariate effects, and the asymptotic properties of the resulting estimators are established. The finite-sample behavior of the proposed estimators is evaluated through simulation studies, and an application to a clinic study on chronic granulomatous disease is provided.     

Working and disability expectancies at older ages: The role of childhood circumstances and education

The ability to work at older ages depends on health and education. Both accumulate starting very early in life. We assess how childhood disadvantages combine with education to affect working and health trajectories. Applying multistate period life tables to data from the Health and Retirement Study (HRS) for the period 2008–2014, we estimate how the residual life expectancy at age 50 is distributed in number of years of work and disability, by number of childhood disadvantages, gender, and race/ethnicity. Our findings indicate that number of childhood disadvantages is negatively associated with work and positively with disability, irrespective of gender and race/ethnicity. Childhood disadvantages intersect with low education resulting in shorter lives, and redistributing life years from work to disability. Among the highly educated, health and work differences between groups of childhood disadvantage are small. Combining multistate models and inverse probability weighting, we show that the return of high education is greater among the most disadvantaged.     

Survival and lifetime data analysis with a flexible class of distributions

We introduce a general class of continuous univariate distributions with positive support obtained by transforming the class of two-piece distributions. We show that this class of distributions is very flexible, easy to implement, and contains members that can capture different tail behaviours and shapes, producing also a variety of hazard functions. The proposed distributions represent a flexible alternative to the classical choices such as the log-normal, Gamma, and Weibull distributions. We investigate empirically the inferential properties of the proposed models through an extensive simulation study. We present some applications using real data in the contexts of time-to-event and accelerated failure time models. In the second kind of applications, we explore the use of these models in the estimation of the distribution of the individual remaining life.