审判委员会制度的理论架构

对审委会制度的改革,有人主张废除审委会制度为其核心内容;也有人主张目前应在保留的基础上予以改革和完善。废改之争,焦点是研究方法之争。主废和主改各有其弊,应通过立法程序按照“不审不判”的思路重塑审委会制度,明确审委会审判组织的地位,赋予其合议、陪审、咨询、调研四大职能及案件实体决定权和指导权,并建立和完善相应的程序。     

Issues in applying recent CPMP ‘Points to Consider’ and FDA guidance documents with biostatistical implications

The International Conference on Harmonisation guideline ‘Statistical Principles for Clinical Trials’ was adopted by the Committee for Proprietary Medicinal Products (CPMP) in March 1998, and consequently is operational in Europe. Since then more detailed guidance on selected topics has been issued by the CPMP in the form of ‘Points to Consider’ documents. The intent of these was to give guidance particularly to non‐statistical reviewers within regulatory authorities, although of course they also provide a good source of information for pharmaceutical industry statisticians. In addition, the Food and Drug Administration has recently issued a draft guideline on data monitoring committees. In November 2002 a one‐day discussion forum was held in London by Statisticians in the Pharmaceutical Industry (PSI). The aim of the meeting was to discuss how statisticians were responding to some of the issues covered in these new guidelines, and to document consensus views where they existed. The forum was attended by industry, academic and regulatory statisticians. This paper outlines the questions raised, resulting discussions and consensus views reached. It is clear from the guidelines and discussions at the workshop that the statistical analysis strategy must be planned during the design phase of a clinical trial and carefully documented. Once the study is complete the analysis strategy should be thoughtfully executed and the findings reported. Copyright © 2003 John Wiley & Sons, Ltd.     

THE SOCIAL IMPACT OF BROADBAND HOUSEHOLD INTERNET ACCESS

Broadband changes everything. Or so we are told. But does it? There is only one way to find out - follow people who move from narrowband to broadband internet access and see what changes. This paper reports exactly this kind of analysis using data from a two wave European panel study (e-Living) and the lagged endogenous regression approach to see if switching to broadband increases the time spent online, the use of online communication services, the breadth of internet activities and the amount of online spend, and whether it decreases the time spent watching TV and the level of social leisure activities. The results suggest, in the main, that switching to broadband made little difference for this group of early broadband adopters who were already heavy internet users. There was no evidence of an online spend or social leisure substitution effect although there was evidence of a reduction in time spent watching television, and an increase in email in use, time spent online and breadth of internet use. In all cases however it was the previous levels of behaviour that were the most significant and switching to broadband was, in general, one of the least strong effects.     

A modified false discovery rate multiple-comparisons procedure for discrete data, applied to human immunodeficiency virus genetics

Summary.  To help to design vaccines for acquired immune deficiency syndrome that protect broadly against many genetic variants of the human immunodeficiency virus, the mutation rates at 118 positions in HIV amino-acid sequences of subtype C versus those of subtype B were compared. The false discovery rate (FDR) multiple-comparisons procedure can be used to determine statistical significance. When the test statistics have discrete distributions, the FDR procedure can be made more powerful by a simple modification. The paper develops a modified FDR procedure for discrete data and applies it to the human immunodeficiency virus data. The new procedure detects 15 positions with significantly different mutation rates compared with 11 that are detected by the original FDR method. Simulations delineate conditions under which the modified FDR procedure confers large gains in power over the original technique. In general FDR adjustment methods can be improved for discrete data by incorporating the modification proposed.     

The Division of Household Labor in Germany and Israel

We compare the patterns of household division of labor in Germany and Israel—two countries that share key elements of the corporatist welfare regime but differ in their gender regimes—and evaluate several hypotheses using data from the 2002 International Social Survey Program. Although time constraints and relative resources affect the division of household labor and women’s housework in both societies, we find that in Germany the gender order of household labor is more rigid, whereas in Israel the spouses’ linked labor market status exerts distinctive effects. We also find significant relationships between gender ideology and the division of household labor. We discuss the theoretical advantages of approaching the comparative study of gender inequality from the vantage point of family and gender regimes.     

东干文——汉语拼音文字的成功尝试

中亚的东干人不仅为该地区的社会经济发展作出了巨大的贡献,而且创造了海外华人历史上的奇迹.他们将带到中亚地区的汉语西北方言拼音化,使用38个斯拉夫字母拼写东干语,采用了词式书写,制订了正字法规则,出版了书报杂志,编写了东干文教科书,并在此基础上还培养了一大批诗人和作家,发展了东干族文学、教育和民族文化.东干文是汉语拼音文字的成功尝试,它为我国现代汉语音素文字的创制和词式书写的语言规化理论和实践提供了有益的经验和启发.     

论我国古代技术创新主体

我国古代技术创新的核心主体是工匠,其承担着技术发明、创新和推广的重要职责。随着技术创新活动的历史演进,在工匠技术创新活动的基础上并以工匠活动为中心相继出现了家庭手工业作坊、私营手工业作坊、手工工场等从事技术创新活动的主体,这些主体在一定程度上克服了工匠主体活动的局限性。工匠主体与这些主体之间并不是简单地以一种单一主体去取代另一种主体,使前一种主体在古代技术创新的舞台中隐退。在我国古代社会的不同历史阶段,这些主体以交叉并存的方式存在。     

农户借款的供求约束及解除

我国的农村金融改革一直是政府导向的,包括现在进行的农村信用社改革。农村金融改革应充分考虑到农村经济主体对资金的需求特征,只有这样,才不致于出现供给缺位和需求得不到满足的情况。因此,研究我国农村中最大的经济主体———农户与正规金融机构之间的借款行为,通过对借贷双     

农户防范返贫:应该更关注人力资本还是社会资本?

基于部分中国家庭追踪调查微观数据,利用多维返贫测算方法识别返贫农户,实证检验了人力资本和社会资本在农户防范返贫中的效应和机制。研究发现:(1)人力资本和社会资本均是防范农户多维返贫的重要因素,但从返贫效应的视角看,人力资本防范返贫的影响更大,是巩固拓展农村脱贫攻坚成果的关键资本。(2)机制分析中,人力资本能发挥迁移效应,通过劳动力流动的部分中介作用防范农户返贫,而社会资本能发挥信息获取和抵押品效应,通过创业的部分中介作用防范农户返贫。(3)人力资本降低了农户在收入、医疗、生活维度的返贫发生概率,社会资本则降低了收入、医疗维度的返贫发生概率。(4)两类资本的防范返贫效应存在区域差异,人力资本显著降低东部和西部农户返贫发生概率,而社会资本显著降低了东部和中部农户返贫发生概率。     

离婚审判中保护当事人探视子女权研究

保护离婚父母探视子女权利的法律制度在我国尚属空白。本文介绍了探视权的概念、特点并简要分析国外探视子女的法律规定及我国探视子女规定的历史和现状,并就设立探视制度、处理探视纠纷等提出具体立法建议