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R. J. Boys D. A. Henderson & D. J. Wilkinson 《Journal of the Royal Statistical Society. Series C, Applied statistics》2000,49(2):269-285
In recent years there has been a rapid growth in the amount of DNA being sequenced and in its availability through genetic databases. Statistical techniques which identify structure within these sequences can be of considerable assistance to molecular biologists particularly when they incorporate the discrete nature of changes caused by evolutionary processes. This paper focuses on the detection of homogeneous segments within heterogeneous DNA sequences. In particular, we study an intron from the chimpanzee α-fetoprotein gene; this protein plays an important role in the embryonic development of mammals. We present a Bayesian solution to this segmentation problem using a hidden Markov model implemented by Markov chain Monte Carlo methods. We consider the important practical problem of specifying informative prior knowledge about sequences of this type. Two Gibbs sampling algorithms are contrasted and the sensitivity of the analysis to the prior specification is investigated. Model selection and possible ways to overcome the label switching problem are also addressed. Our analysis of intron 7 identifies three distinct homogeneous segment types, two of which occur in more than one region, and one of which is reversible. 相似文献
13.
国际关系理论中的主权与人权问题 总被引:1,自引:0,他引:1
主权与人权问题不仅是国际关系理论的两个主要范畴,也是给当今国际社会现实生活带来巨大影响的热点。在诸如主权原则、人权概念、二者的关系,人权的国际化趋势与国内管辖权的矛盾,以及由此对传统国际关系理论造成的冲击和对国际法、国际关系基本准则的挑战等方面,人们确有深入思考、探究和冷静应对的必要 相似文献
14.
Fu Chonglun 《电子科技大学学报(社会科学版)》1986,(4)
本文介绍了人机工程学(工效学)这一新兴边缘学科的研究内容、发展及现状,讨论了人-机系统的可靠性并着重讨论了人的操作可靠性,探讨了按人为差错进行可靠性分析与可靠性估计的人为差错和可靠性分析逻辑推演法(HERALD法)及系统能力方法(SC方法)。 本文的结论可供系统管理工作者及设计工作者,特别是可靠性管理及可靠性设计工作者参考。 相似文献
15.
A general approach for modeling the volatility process in continuous-time is based on the convolution of a kernel with a non-decreasing Lévy process, which is non-negative if the kernel is non-negative. Within the framework of Continuous-time Auto-Regressive Moving-Average (CARMA) processes, we derive a necessary condition for the kernel to be non-negative, and propose a numerical method for checking the non-negativity of a kernel function. These results can be lifted to solving a similar problem with another approach to modeling volatility via the COntinuous-time Generalized Auto-Regressive Conditional Heteroscedastic (COGARCH) processes. 相似文献
16.
Hélcio Vieira Jr. Karl Heinz Kienitz Mischel Carmen Neyra Belderrain 《统计学通讯:模拟与计算》2013,42(5):971-980
The two well-known and widely used multinomial selection procedures Bechhofor, Elmaghraby, and Morse (BEM) and all vector comparison (AVC) are critically compared in applications related to simulation optimization problems. Two configurations of population probability distributions in which the best system has the greatest probability p i of yielding the largest value of the performance measure and has or does not have the largest expected performance measure were studied. The numbers achieved by our simulations clearly show that none of the studied procedures outperform the other in all situations. The user must take into consideration the complexity of the simulations and the performance measure probability distribution properties when deciding which procedure to employ. An important discovery was that the AVC does not work in populations in which the best system has the greatest probability p i of yielding the largest value of the performance measure but does not have the largest expected performance measure. 相似文献
17.
In this article, we present the problem of selecting a good stochastic system with high probability and minimum total simulation cost when the number of alternatives is very large. We propose a sequential approach that starts with the Ordinal Optimization procedure to select a subset that overlaps with the set of the actual best m% systems with high probability. Then we use Optimal Computing Budget Allocation to allocate the available computing budget in a way that maximizes the Probability of Correct Selection. This is followed by a Subset Selection procedure to get a smaller subset that contains the best system among the subset that is selected before. Finally, the Indifference-Zone procedure is used to select the best system among the survivors in the previous stage. The numerical test involved with all these procedures shows the results for selecting a good stochastic system with high probability and a minimum number of simulation samples, when the number of alternatives is large. The results also show that the proposed approach is able to identify a good system in a very short simulation time. 相似文献
18.
In this article, we present a compressive sensing based framework for generalized linear model regression that employs a two-component noise model and convex optimization techniques to simultaneously detect outliers and determine optimally sparse representations of noisy data from arbitrary sets of basis functions. We then extend our model to include model order reduction capabilities that can uncover inherent sparsity in regression coefficients and achieve simple, superior fits. Second, we use the mixed ?2/?1 norm to develop another model that can efficiently uncover block-sparsity in regression coefficients. By performing model order reduction over all independent variables and basis functions, our algorithms successfully deemphasize the effect of independent variables that become uncorrelated with dependent variables. This desirable property has various applications in real-time anomaly detection, such as faulty sensor detection and sensor jamming in wireless sensor networks. After developing our framework and inheriting a stable recovery theorem from compressive sensing theory, we present two simulation studies on sparse or block-sparse problems that demonstrate the superior performance of our algorithms with respect to (1) classic outlier-invariant regression techniques like least absolute value and iteratively reweighted least-squares and (2) classic sparse-regularized regression techniques like LASSO. 相似文献
19.
A well-known procedure for the optimization of a second-degree response function over a spherical region of interest is that of ridge analysis. Khuri and Myers (1979) introduced a modification of this procedure by incorporating a certain constraint on the prediction variance. Both procedures, however, assume that the response variable has a constant variance throughtout the experimental region. In the present article, we consider two extensions to Khuri and Myers modifioed ridge analysis. The first extension relaxes the constant variance assumption. In the second extension. generalised linear models are used instead of the trasitional linear model. which are commenly used in responce variables that are not necessaily continusly distribution, including these have discreate distributions, Two examples are presented to illustrate the implementation of the proposed extensions. 相似文献
20.
Chung-Ho Chen 《统计学通讯:理论与方法》2013,42(10):1767-1778
Economic selection of process parameters has been an important topic in modern statistical process control. The optimum process parameters setting have a major effect on the expected profit/cost per item. There are some concerns on the problem of setting process parameters. Boucher and Jafari (1991) first considered the attribute single sampling plan applied in the selection of process target. Pulak and Al-Sultan (1996) extended Boucher and Jafari's model and presented the rectifying inspection plan for determining the optimum process mean. In this article, we further propose a modified Pulak and Al-Sultan model for determining the optimum process mean and standard deviation under the rectifying inspection plan with the average outgoing quality limit (AOQL) protection. Taguchi's (1986) symmetric quadratic quality loss function is adopted for evaluating the product quality. By solving the modified model, we can obtain the optimum process parameters with the maximum expected profit per item and the specified quality level can be reached. 相似文献