系统法在课程教学改革中的应用研究

本文以系统方法为指导,就日语专业《高级日语》课从明确教学目标和要求、做好授课前的准备工作、注重课堂教学方法的针对性使用、开展有效的课外活动等四个环节试作论述。     

Multiparameter evidence synthesis in epidemiology and medical decision-making: current approaches

Summary.  Alongside the development of meta-analysis as a tool for summarizing research literature, there is renewed interest in broader forms of quantitative synthesis that are aimed at combining evidence from different study designs or evidence on multiple parameters. These have been proposed under various headings: the confidence profile method, cross-design synthesis, hierarchical models and generalized evidence synthesis. Models that are used in health technology assessment are also referred to as representing a synthesis of evidence in a mathematical structure. Here we review alternative approaches to statistical evidence synthesis, and their implications for epidemiology and medical decision-making. The methods include hierarchical models, models informed by evidence on different functions of several parameters and models incorporating both of these features. The need to check for consistency of evidence when using these powerful methods is emphasized. We develop a rationale for evidence synthesis that is based on Bayesian decision modelling and expected value of information theory, which stresses not only the need for a lack of bias in estimates of treatment effects but also a lack of bias in assessments of uncertainty. The increasing reliance of governmental bodies like the UK National Institute for Clinical Excellence on complex evidence synthesis in decision modelling is discussed.     

Bayesian palaeoclimate reconstruction

Summary.  We consider the problem of reconstructing prehistoric climates by using fossil data that have been extracted from lake sediment cores. Such reconstructions promise to provide one of the few ways to validate modern models of climate change. A hierarchical Bayesian modelling approach is presented and its use, inversely, is demonstrated in a relatively small but statistically challenging exercise: the reconstruction of prehistoric climate at Glendalough in Ireland from fossil pollen. This computationally intensive method extends current approaches by explicitly modelling uncertainty and reconstructing entire climate histories. The statistical issues that are raised relate to the use of compositional data (pollen) with covariates (climate) which are available at many modern sites but are missing for the fossil data. The compositional data arise as mixtures and the missing covariates have a temporal structure. Novel aspects of the analysis include a spatial process model for compositional data, local modelling of lattice data, the use, as a prior, of a random walk with long-tailed increments, a two-stage implementation of the Markov chain Monte Carlo approach and a fast approximate procedure for cross-validation in inverse problems. We present some details, contrasting its reconstructions with those which have been generated by a method in use in the palaeoclimatology literature. We suggest that the method provides a basis for resolving important challenging issues in palaeoclimate research. We draw attention to several challenging statistical issues that need to be overcome.     

Adaptive Estimation Using Weighted Least Squares

This paper proposes an adaptive estimator that is more precise than the ordinary least squares estimator if the distribution of random errors is skewed or has long tails. The adaptive estimates are computed using a weighted least squares approach with weights based on the lengths of the tails of the distribution of residuals. Smaller weights are assigned to those observations that have residuals in the tails of long-tailed distributions and larger weights are assigned to observations having residuals in the tails of short-tailed distributions. Monte Carlo methods are used to compare the performance of the proposed estimator and the performance of the ordinary least squares estimator. The estimates that were studied in this simulation include the difference between the means of two populations, the mean of a symmetric distribution, and the slope of a regression line. The adaptive estimators are shown to have lower mean squared errors than those for the ordinary least squares estimators for short-tailed, long-tailed, and skewed distributions, provided the sample size is at least 20. The ordinary least squares estimator has slightly lower mean squared error for normally distributed errors. The adaptive estimator is recommended for general use for studies having sample sizes of at least 20 observations unless the random errors are known to be normally distributed.     

Improving coverage accuracy of nonparametric prediction intervals

Methods are suggested for improving the coverage accuracy of intervals for predicting future values of a random variable drawn from a sampled distribution. It is shown that properties of solutions to such problems may be quite unexpected. For example, the bootstrap and the jackknife perform very poorly when used to calibrate coverage, although the jackknife estimator of the true coverage is virtually unbiased. A version of the smoothed bootstrap can be employed for successful calibration, however. Interpolation among adjacent order statistics can also be an effective way of calibrating, although even there the results are unexpected. In particular, whereas the coverage error can be reduced from O ( n ^-1) to orders O ( n ^-2) and O ( n ^-3) (where n denotes the sample size) by interpolating among two and three order statistics respectively, the next two orders of reduction require interpolation among five and eight order statistics respectively.     

Using adaptive weighted least squares to reduce the lengths of confidence intervals

The author proposes an adaptive method which produces confidence intervals that are often narrower than those obtained by the traditional procedures. The proposed methods use both a weighted least squares approach to reduce the length of the confidence interval and a permutation technique to insure that its coverage probability is near the nominal level. The author reports simulations comparing the adaptive intervals to the traditional ones for the difference between two population means, for the slope in a simple linear regression, and for the slope in a multiple linear regression having two correlated exogenous variables. He is led to recommend adaptive intervals for sample sizes superior to 40 when the error distribution is not known to be Gaussian.     

Detecting homogeneous segments in DNA sequences by using hidden Markov models

In recent years there has been a rapid growth in the amount of DNA being sequenced and in its availability through genetic databases. Statistical techniques which identify structure within these sequences can be of considerable assistance to molecular biologists particularly when they incorporate the discrete nature of changes caused by evolutionary processes. This paper focuses on the detection of homogeneous segments within heterogeneous DNA sequences. In particular, we study an intron from the chimpanzee α-fetoprotein gene; this protein plays an important role in the embryonic development of mammals. We present a Bayesian solution to this segmentation problem using a hidden Markov model implemented by Markov chain Monte Carlo methods. We consider the important practical problem of specifying informative prior knowledge about sequences of this type. Two Gibbs sampling algorithms are contrasted and the sensitivity of the analysis to the prior specification is investigated. Model selection and possible ways to overcome the label switching problem are also addressed. Our analysis of intron 7 identifies three distinct homogeneous segment types, two of which occur in more than one region, and one of which is reversible.     

Binary probability maps using a hidden conditional autoregressive Gaussian process with an application to Finnish common toad data

The Finnish common toad data of Heikkinen and Hogmander are reanalysed using an alternative fully Bayesian model that does not require a pseudolikelihood approximation and an alternative prior distribution for the true presence or absence status of toads in each 10 km×10 km square. Markov chain Monte Carlo methods are used to obtain posterior probability estimates of the square-specific presences of the common toad and these are presented as a map. The results are different from those of Heikkinen and Hogmander and we offer an explanation in terms of the prior used for square-specific presence of the toads. We suggest that our approach is more faithful to the data and avoids unnecessary confounding of effects. We demonstrate how to extend our model efficiently with square-specific covariates and illustrate this by introducing deterministic spatial changes.     

六端口技术自校准方法解的不唯一性证明

本文就六端口技术自校准方法进行了分析讨论,用解析方法和计算机模拟方法分别证明了自校准方法解的不唯一性.从而否定了自校准方法是六端口技术最突出的优点之一这个传统概念.     

Robust tests for the common principal components model

When dealing with several populations, the common principal components (CPC) model assumes equal principal axes but different variances along them. In this paper, a robust log-likelihood ratio statistic allowing to test the null hypothesis of a CPC model versus no restrictions on the scatter matrices is introduced. The proposal plugs into the classical log-likelihood ratio statistic robust scatter estimators. Using the same idea, a robust log-likelihood ratio and a robust Wald-type statistic for testing proportionality against a CPC model are considered. Their asymptotic distributions under the null hypothesis and their partial influence functions are derived. A small simulation study allows to compare the behavior of the classical and robust tests, under normal and contaminated data.