An efficient sequential design of clinical trials

We propose an efficient group sequential monitoring rule for clinical trials. At each interim analysis both efficacy and futility are evaluated through a specified loss structure together with the predicted power. The proposed design is robust to a wide range of priors, and achieves the specified power with a saving of sample size compared to existing adaptive designs. A method is also proposed to obtain a reduced-bias estimator of treatment difference for the proposed design. The new approaches hold great potential for efficiently selecting a more effective treatment in comparative trials. Operating characteristics are evaluated and compared with other group sequential designs in empirical studies. An example is provided to illustrate the application of the method.     

Asymptotic normality of Huber–Dutter estimators in a linear model with AR(1) processes

The paper studies a linear regression model with first order autoregressive (AR(1)) processes. The Huber–Dutter (HD) estimators of unknown parameters are given, and the asymptotic normality of the HD estimators is investigated. An example is presented to illustrate the proposed method.     

中国通货膨胀率的非线性动态行为研究——来自MS—ARFIMA模型的新证据

使用允许长记忆参数d服从区制转换的MS—ARFIMA模型对中国月度通货膨胀路径的动态行为进行新的实证研究,结果显示：中国通货膨胀不仅均值水平和不确定性存在着“低通胀”区制和“高通胀”区制,而且更为重要的是,通货膨胀序列的平稳性也表现出显著的区制转换动态。“低通胀”区制下,长记忆参数d1=0．361,说明通货膨胀是协方差平稳序列,“高通胀”区制下,长记忆参数d2=1．145,说明通货膨胀是非平稳序列。这一新的研究结论意味着中国通货膨胀冲击的持久性效应也存在相应的区制转移变化。这要求央行在管控通货膨胀过程中,既要考虑均值和不确定性的区制变化,又要兼顾平稳性和持久性的区制变化。     

中国居民收入分布专题实证研究——居民收入分布变迁测度及其影响因素分解

基于核密度估计方法,给出居民收入分布变迁测度及其影响因素分解的相对收入分布方法。使用中国健康和营养调查的微观居民收入数据,实证分析中国居民收入分布及其变迁的特征、过程及其影响因素。实证结果显示:中国居民收入分布变迁的速度与经济体制改革进程相对应;经济增长因素是引起居民收入分布变迁的主要因素,在提高总体居民收入水平的同时加剧了居民收入分布的极化程度;收入分配因素对居民收入分布变迁的作用相对较弱,但有一定的减贫或缩小居民收入差距作用。     

基于改进D—S证据理论的TOPSIS模型在科技奖励评价中的应用

针对科技奖励评价的特点,根据改进D—S证据合成规则,将专家的评价指标值转化为指标的综合得分并形成决策矩阵;结合TOPSIS模型求解理想解和负理想解,计算距离和贴近度,对各评价项目进行综合排名。实证结果表明：该模型能够很好地解决科技奖励评价过程中的不确定性问题,为科技奖励综合评价提供了一种新的思路。     

公平分配与居民福利——收入差距对中国居民恩格尔系数的影响分析

居民收入水平不同,恩格尔系数也不同,因此收入分配对社会总体恩格尔系数的影响是不确定的。基于马斯洛层次需求理论证明边际食品消费倾向递减,并且当消费函数为线性或近似线性时,收入差距扩大会降低恩格尔系数。基于省际面板数据的实证分析表明,中国居民边际食品消费倾向递减且消费函数为(近似)线性,居民收入差距扩大降低了居民恩格尔系数(基尼系数升高对恩格尔系数下降的贡献率为22%),从而出现"分配越不平等,居民总体生活水平越高"的矛盾现象。因此在使用总体指标评价居民生活水平时,收入分配指标必须得到同等的重视;在经济发展中,公平和效率必须兼顾才能实现居民福利最大化。     

中国粮食价格波动特征研究——基于X-12-ARIMA模型和ARCH类模型

以小麦和大豆为例,研究2002年1月至2012年6月中国粮食价格波动特征。首先利用X-12-ARIMA模型对价格序列进行季节调整,然后运用ARCH类模型对剥离季节因素的价格序列进行波动分析。结果发现:中国粮食价格季节性波动逐年减弱;粮食价格具有明显的波动集簇性,前期价格波动和外部冲击对后期价格的影响具有持续性;粮食市场不存在"高风险、高回报"特征;小麦价格波动的非对称性不显著,而大豆价格波动则呈现明显的非对称特征,且上期价格上涨信息引发的波动要大于下跌信息。     

Pmc-optimal nonparametric quantile estimator

According to Pitman's Measure of Closeness, if T₁and T₂are two estimators of a real parameter $[d], then T₁is better than T₂if Po[d]{T₁-o[d] < T₂-0[d]} > 1/2 for all 0[d]. It may however happen that while T₁is better than T₂and T₂is better than T₃, T₃is better than T₁. Given q ? (0,1) and a sample X₁, X₂, ..., X_nfrom an unknown F ? F, an estimator T* = T*(X₁,X₂...X_n)of the q-th quantile of the distribution F is constructed such that P_F{F(T*)-q <[d] F(T)-q} >[d] 1/2 for all F?F and for all T€T, where F is a nonparametric family of distributions and T is a class of estimators. It is shown that T* =X_j:n'for a suitably chosen jth order statistic.     

Generalized exponential distribution: Moments of order statistics

In this paper, we consider the generalized exponential distribution (GED) with shape parameter α. We establish several recurrence relations satisfied by the single and the product moments for order statistics from the GED. The relationships can be written in terms of polygamma and hypergeometric functions and used in a simple recursive manner in order to compute the single and the product moments of all order statistics for all sample sizes.     

The asymptotic distribution of the partial attributable risk in cross-sectional studies

The partial attributable risk (PAR) has been introduced as a tool for partitioning the responsibility for causing an adverse event between various risk factors. It has arisen from epidemiology, but it is also a valid general risk allocation concept, which can, for example, be applied to data from customer satisfaction surveys. So far, a variance formula for the PAR has been missing so that the confidence intervals were not directly available. This paper provides the asymptotic normal distribution for the PAR determined from a cross-sectional study.