A multivariate zero-inflated binomial model for the analysis of correlated proportional data

In this paper, a new multivariate zero-inflated binomial (MZIB) distribution is proposed to analyse the correlated proportional data with excessive zeros. The distributional properties of purposed model are studied. The Fisher scoring algorithm and EM algorithm are given for the computation of estimates of parameters in the proposed MZIB model with/without covariates. The score tests and the likelihood ratio tests are derived for assessing both the zero-inflation and the equality of multiple binomial probabilities in correlated proportional data. A limited simulation study is performed to evaluate the performance of derived EM algorithms for the estimation of parameters in the model with/without covariates and to compare the nominal levels and powers of both score tests and likelihood ratio tests. The whitefly data is used to illustrate the proposed methodologies.     

SMOOTH TESTS FOR THE BIVARIATE POISSON DISTRIBUTION

A theorem of Rayner & Best (1989) is generalised to permit the construction of smooth tests of goodness of fit without requiring a set of orthonormal functions on the hypothesised distribution. This result is used to construct smooth tests for the bivariate Poisson distribution. The test due to Crockett (1979) is similar to a smooth test that assesses the variance structure under the bivariate Poisson model; the test due to Loukas & Kemp (1986) is related to a smooth test that seeks to detect a particular linear relationship between the variances and covariance under the bivariate Poisson model. Using focused smooth tests may be more informative than using previously suggested tests. The distribution of the Loukas & Kemp (1986) statistic is not well approximated by the x²distribution for larger correlations, and a revised statistic is suggested.     

Efficient score tests for heteroskedasticity in micro-economics

This paper develops an artificial regression that can be employed to obtain efficient score test statistics for heteroskedasticity in the context of a variety of micro-econometric models     

Modeling Two-state Disease Processes with Random Effects

Many chronic medical conditions are manifested by alternating sojourns in symptom-free and symptomatic states. In many cases, in addition to their relapsing and remitting nature, these conditions lead to worsening disease patterns over time and may exhibit seasonal trends. We develop a mixed-effect two-state model for such disease processes in which covariate effects are modeled multiplicatively on transition intensities. The transition intensities, in turn, are functions of three time scales: the semi-Markov scale involving the backward recurrence time for the cyclical component, the Markov scale for the time trend component, and a seasonal time scale. Multiplicative bivariate log-normal random effects are introduced to accommodate heterogeneity in disease activity between subjects and to admit a possible negative correlation between the transition intensities. Maximum likelihood estimation is carried out using Gauss-Hermite integration and a standard Newton-Raphson procedure. Tests of homogeneity are presented based on score statistics. An application of the methodology to data from a multi-center clinical trial of chronic bronchitis is provided for illustrative purposes.     

A Second-order Adjustment to the Profile Likelihood in the Case of a Multidimensional Parameter of Interest

Inference in the presence of nuisance parameters is often carried out by using the χ²-approximation to the profile likelihood ratio statistic. However, in small samples, the accuracy of such procedures may be poor, in part because the profile likelihood does not behave as a true likelihood, in particular having a profile score bias and information bias which do not vanish. To account better for nuisance parameters, various researchers have suggested that inference be based on an additively adjusted version of the profile likelihood function. Each of these adjustments to the profile likelihood generally has the effect of reducing the bias of the associated profile score statistic. However, these adjustments are not applicable outside the specific parametric framework for which they were developed. In particular, it is often difficult or even impossible to apply them where the parameter about which inference is desired is multidimensional. In this paper, we propose a new adjustment function which leads to an adjusted profile likelihood having reduced score and information biases and is readily applicable to a general parametric framework, including the case of vector-valued parameters of interest. Examples are given to examine the performance of the new adjusted profile likelihood in small samples, and also to compare its performance with other adjusted profile likelihoods.     

高校海归教师群体工作满意度的测量及影响因素分析——基于“学术职业发展状况第三次全球调查”的数据

近年来,中国高校中海归教师群体的比例不断扩大,高校海归教师正逐渐成为促进中国高等教育发展的重要力量。深入了解高校海归教师的工作满意度,并据此提出提升其工作满意度的政策建议具有一定的现实意义。基于“学术职业发展状况第三次全球调查”数据,对高校海归教师群体的工作满意度进行实证分析。研究发现,高校海归教师群体对聘任状态、工作环境、收入状况及整体职业环境的满意度呈现出较大差异。基于此,对提升高校海归教师群体工作满意度提出了若干建议。     

Integrating phase 2 into phase 3 based on an intermediate endpoint while accounting for a cure proportion—With an application to the design of a clinical trial in acute myeloid leukemia

For a trial with primary endpoint overall survival for a molecule with curative potential, statistical methods that rely on the proportional hazards assumption may underestimate the power and the time to final analysis. We show how a cure proportion model can be used to get the necessary number of events and appropriate timing via simulation. If phase 1 results for the new drug are exceptional and/or the medical need in the target population is high, a phase 3 trial might be initiated after phase 1. Building in a futility interim analysis into such a pivotal trial may mitigate the uncertainty of moving directly to phase 3. However, if cure is possible, overall survival might not be mature enough at the interim to support a futility decision. We propose to base this decision on an intermediate endpoint that is sufficiently associated with survival. Planning for such an interim can be interpreted as making a randomized phase 2 trial a part of the pivotal trial: If stopped at the interim, the trial data would be analyzed, and a decision on a subsequent phase 3 trial would be made. If the trial continues at the interim, then the phase 3 trial is already underway. To select a futility boundary, a mechanistic simulation model that connects the intermediate endpoint and survival is proposed. We illustrate how this approach was used to design a pivotal randomized trial in acute myeloid leukemia and discuss historical data that informed the simulation model and operational challenges when implementing it.     

Using Inverse Probability Weighting Estimators to Evaluate Various Propensity Scores When Treatment Switching Exists

In this paper, we conduct a Monte Carlo simulation study to evaluate three propensity score (PS) scenarios for estimating an average treatment effect (ATE) in observational studies when treatment switching exists: (a) ignoring treatment switching in subjects (UPS), (b) removing subjects with treatment switching (RPS), and (c) adjusting for treatment switching effect (APS) with two inverse probability weighting estimators, IPW1 and IPW2. We evaluate these six estimators in terms of bias, mean squared error (MSE), empirical standard error (ESE), and coverage probability (CP) under various simulation scenarios. Simulation results show that the IPW2 estimator with RPS has relatively good performance.     

Global kernel estimator and test of varying‐coefficient autoregressive model

We propose a varying‐coefficient autoregressive model that contains additive models, varying‐ coefficient models, partially linear models and low‐dimensional interaction models as special cases. A global kernel backfitting method is proposed for the estimation and inference of parameters and unknown functions in this model. Key large‐sample results are established, including estimation consistency, asymptotic normality and the generalized likelihood ratio test for parameters and non‐parametric functions. The proposed methodology is examined by simulation studies and applied to examine the relationship between suicide news reports in the three leading newspapers and the daily number of suicides in Taiwan. The relationship between the media reporting and suicide incidence has been established and explored. The Canadian Journal of Statistics 47: 487–519; 2019 © 2019 Statistical Society of Canada     

The effects of propensity score weighting on attrition biases in attitudinal,behavioral, and socio-demographic variables in a short-term web-based panel survey

Propensity score weighting often is used to correct for attrition biases in panel surveys. While methodological literature exists on the logic of propensity score weighting and its practical applications, an in-depth discussion is lacking on the effects of using this weighting to correct for attrition biases in attitudinal, behavioral, and socio-demographic variables. By applying a split panel design, we assessed the effects of weighting on attrition biases in 48 attitudinal, 38 behavioral, and 27 socio-demographic variables. Our findings suggest – while acknowledging the estimate-specific nature of bias – first, that biases vary across these types of variables and second, that the effects of propensity score weighting are not homogeneous across the types. Accordingly, a sole reliance on socio-demographics to evaluate attrition in the present panel survey would have resulted in an underestimation of the biases of attitudinal variables and an overestimation of the ability of weighting to cure the negative effects of attrition in behavioral variables.