An improved comorbidity summary score for measuring disease burden and predicting mortality with applications to two national cohorts

Abstract

Research involving administrative healthcare data to study patient outcomes requires the investigator to account for the patient’s disease burden in order to reduce the potential for biased results. Here we develop a comorbidity summary score based on variable importance measures derived from several statistical and machine learning methods and show it has superior predictive performance to the Elixhauser and Charlson indices when used to predict 1-year, 5-year, and 10-year mortality. We used two large Veterans Administration cohorts to develop and validate the summary score and compared predictive performance using the area under ROC curve (AUC) and the Brier score.     

Analysing exponential family based messy data

Recently exponential family based random effects models have received considerable attention. These models usually arise from an unobservable random process added to the independent exponential family models. An unobservable correlated process, however, would cause correlations among the exponential family based data. This paper, first, develops an asymptotically optimal test for testing the appropriateness of a fixed effects model for the exponential family based independent data versus a random effects model for the exponential family based independent or correlated data. The paper, then, provides a general framework on regression analysis for the exponential family based data generated under the random effects models.     

Multivariate Control Charts Based on Hybrid Novelty Scores

We propose a new nonparametric multivariate control chart that integrates a novelty score. The proposed control chart uses as its monitoring statistic a hybrid novelty score, calculated based on the distance to local observations as well as on the distance to the convex hull constructed by its neighbors. The control limits of the proposed control chart were established based on a bootstrap method. A rigorous simulation study was conducted to examine the properties of the proposed control chart under various scenarios and compare it with existing multivariate control charts in terms of average run length (ARL) performance. The simulation results showed that the proposed control chart outperformed both the parametric and nonparametric Hotelling's T ² control charts, especially in nonnormal situations. Moreover, experimental results with real semiconductor data demonstrated the applicability and effectiveness of the proposed control chart. To increase the capability to detect small mean shift, we propose an exponentially weighted hybrid novelty score control chart. Simulation results indicated that exponentially weighted hybrid score charts outperformed the hybrid novelty score based control charts.     

Optimal testing in a three way anova model

We consider likelihood ratio, score and Wald tests for a three-way random effects ANOVA model. Competitor tests are compared using criteria such as small sample power, asymptotic relative efficiency, and convenient null distribution. The final choice is between a new test and two tests long used in practice.     

Exact likelihood ratio and score confidence intervals for the binomial proportion

Many methods are available for computing a confidence interval for the binomial parameter, and these methods differ in their operating characteristics. It has been suggested in the literature that the use of the exact likelihood ratio (LR) confidence interval for the binomial proportion should be considered. This paper provides an evaluation of the operating characteristics of the two‐sided exact LR and exact score confidence intervals for the binomial proportion and compares these results to those for three other methods that also strictly maintain nominal coverage: Clopper‐Pearson, Blaker, and Casella. In addition, the operating characteristics of the two‐sided exact LR method and exact score method are compared with those of the corresponding asymptotic methods to investigate the adequacy of the asymptotic approximation. Copyright © 2013 John Wiley & Sons, Ltd.     

Semiparametric score test for varying copula parameter in Markov time series

This article examines a semiparametric test for checking the constancy of serial dependence via copula models for Markov time series. A semiparametric score test is proposed for testing the constancy of the copula parameter against stochastically varying copula parameter. The asymptotic null distribution of the test is established. A semiparametric bootstrap procedure is employed for the estimation of the variance of the proposed score test. Illustrations are given based on simulated series and historic interest rate data.     

On confidence regions of semiparametric nonlinear reproductive dispersion models

This article investigates the confidence regions for semiparametric nonlinear reproductive dispersion models (SNRDMs), which is an extension of nonlinear regression models. Based on local linear estimate of nonparametric component and generalized profile likelihood estimate of parameter in SNRDMs, a modified geometric framework of Bates and Wattes is proposed. Within this geometric framework, we present three kinds of improved approximate confidence regions for the parameters and parameter subsets in terms of curvatures. The work extends the previous results of Hamilton et al. [in Accounting for intrinsic nonlinearity in nonlinear regression parameter inference regions, Ann. Statist. 10, pp. 386–393, 1982], Hamilton [in Confidence regions for parameter subset in nonlinear regression, Biometrika, 73, pp. 57–64, 1986], Wei [in On confidence regions of embedded models in regular parameter families (a geometric approch), Austral. J. Statist. 36, pp. 327–338, 1994], Tang et al. [in Confidence regions in quasi-likelihood nonlinear models: a geometric approach, J. Biomath. 15, pp. 55–64, 2000b] and Zhu et al. [in On confidence regions of semiparametric nonlinear regression models, Acta. Math. Scient. 20, pp. 68–75, 2000].     

Asymptotic properties of a rank estimate in linear regression with symmetric non-identically distributed errors

In this article, a simple linear regression model with independent and symmetric but non-identically distributed errors is considered. Asymptotic properties of the rank regression estimate defined in Jaeckel [Estimating regression coefficients by minimizing the dispersion of the residuals, Ann. Math. Statist. 43 (1972), pp. 1449–1458] are studied. We show that the studied estimator is consistent and asymptotically normally distributed. The cases of bounded and unbounded score functions are examined separately. The regularity conditions of the article are exemplified for finite mixture distributions.     

参加医疗保险对农村居民健康的影响——基于CHARLS 2015数据的实证分析

基于CHARLS 2015数据,采用倾向得分匹配法实证分析参加医疗保险对农村居民健康的影响。研究发现:参加医疗保险对农村居民的日常活动能力和自评健康影响不显著,参加医疗保险对农村居民认知能力具有显著的正向影响。据此提出,应进一步提升社会医疗保险保障水平、扩大社会医疗保险保障范围、促进商业医疗保险有序发展、推进"三医"高效协同联动等,以充分发挥医疗保险的健康保障功能,从而进一步提升参加医疗保险对农村居民健康的正向影响。     

Tests for homogeneity of risk differences in stratified design with correlated bilateral data

ABSTRACT

Correlated bilateral data arise from stratified studies involving paired body organs in a subject. When it is desirable to conduct inference on the scale of risk difference, one needs first to assess the assumption of homogeneity in risk differences across strata. For testing homogeneity of risk differences, we herein propose eight methods derived respectively from weighted-least-squares (WLS), the Mantel-Haenszel (MH) estimator, the WLS method in combination with inverse hyperbolic tangent transformation, and the test statistics based on their log-transformation, the modified Score test statistic and Likelihood ratio test statistic. Simulation results showed that four of the tests perform well in general, with the tests based on the WLS method and inverse hyperbolic tangent transformation always performing satisfactorily even under small sample size designs. The methods are illustrated with a dataset.