Case–control studies with complex sampling

The use of complex sampling designs in population-based case–control studies is becoming more common, particularly for sampling the control population. This is prompted by all the usual cost and logistical benefits that are conferred by multistage sampling. Complex sampling has often been ignored in analysis but, with the advent of packages like SUDAAN, survey-weighted analyses that take account of the sample design can be carried out routinely. This paper explores this approach and more efficient alternatives, which can also be implemented by using readily available software.     

Heteroscedastic Regression Models and Applications to Off-line Quality Control

We discuss in the present paper the analysis of heteroscedastic regression models and their applications to off-line quality control problems. It is well known that the method of pseudo-likelihood is usually preferred to full maximum likelihood since estimators of the parameters in the regression function obtained are more robust to misspecification of the variance function. Despite its popularity, however, existing theoretical results are difficult to apply and are of limited use in many applications. Using more recent results in estimating equations, we obtain an efficient algorithm for computing the pseudo-likelihood estimator with desirable convergence properties and also derive simple, explicit and easy to apply asymptotic results. These results are used to look in detail at variance minimization in off-line quality control, yielding techniques of inferences for the optimized design parameter. In application of some existing approaches to off-line quality control, such as the dual response methodology, rigorous statistical inference techniques are scarce and difficult to obtain. An example of off-line quality control is presented to discuss the practical aspects involved in the application of the results obtained and to address issues such as data transformation, model building and the optimization of design parameters. The analysis shows very encouraging results, and is seen to be able to unveil some important information not found in previous analyses.     

A likelihood ratio test for goodness‐of‐fit of recessive and dominant models for case–control studies

Testing goodness‐of‐fit of commonly used genetic models is of critical importance in many applications including association studies and testing for departure from Hardy–Weinberg equilibrium. Case–control design has become widely used in population genetics and genetic epidemiology, thus it is of interest to develop powerful goodness‐of‐fit tests for genetic models using case–control data. This paper develops a likelihood ratio test (LRT) for testing recessive and dominant models for case–control studies. The LRT statistic has a closed‐form formula with a simple $\chi^{2}(1)$ null asymptotic distribution, thus its implementation is easy even for genome‐wide association studies. Moreover, it has the same power and optimality as when the disease prevalence is known in the population. The Canadian Journal of Statistics 41: 341–352; 2013 © 2013 Statistical Society of Canada     

Alternative Factors for Control Chart Construction

Conflicting decision signals resulting from Shewhart Mean and Variability Control Charts produce undesirable consequences. Therefore, we construct “six-sigma” control charts by alternative methods to avoid problems associated with Control Charts yielding different signals. By adjusting methods for control chart construction for dispersion charts, we produce new reference tables. The new tables provide consistent signals and appear similar and familiar to users of historical tables.     

A Multivariate Synthetic Control Chart for Monitoring the Process Mean Vector of Skewed Populations Using Weighted Standard Deviations

This article proposes a multivariate synthetic control chart for skewed populations based on the weighted standard deviation method. The proposed chart incorporates the weighted standard deviation method into the standard multivariate synthetic control chart. The standard multivariate synthetic chart consists of the Hotelling's T ² chart and the conforming run length chart. The weighted standard deviation method adjusts the variance–covariance matrix of the quality characteristics and approximates the probability density function using several multivariate normal distributions. The proposed chart reduces to the standard multivariate synthetic chart when the underlying distribution is symmetric. In general, the simulation results show that the proposed chart performs better than the existing multivariate charts for skewed populations and the standard T ² chart, in terms of false alarm rates as well as moderate and large mean shift detection rates based on the various degrees of skewnesses.     

The computational aspects of multiple attribute sampling procedures

One method of controlling the quality of incoming lots is through attribute sampling. To simultaneously control several (possibly dependent) attributes, properly chosen single attribute sampling plans can be merged into a multiple attribute sampling plan. The general form of such a plan is given and various alternatives are discussed. The multinomial distribution is used to develop formulae necessary for an analysis of a multiple attribute plan. Due to the lengthy nature of the calculations involved, a computer algorithm is outlined.     

Determining Optimal Number of Samples for Constructing Multivariate Control Charts

Normally, an average run length (ARL) is used as a measure for evaluating the detecting performance of a multivariate control chart. This has a direct impact on the false alarm cost in Phase II. In this article, we first conduct a simulation study to calculate both in-control and out-of-control ARLs under various combinations of process shifts and number of samples. Then, a trade-off analysis between sampling inspection and false alarm costs is performed. Both the simulation results and trade-off analysis suggest that the optimal number of samples for constructing a multivariate control chart in Phase I can be determined.     

The Effect of Methods for Handling Missing Values on the Performance of the MEWMA Control Chart

This article is concerned with the effect of the methods for handling missing values in multivariate control charts. We discuss the complete case, mean substitution, regression, stochastic regression, and the expectation–maximization algorithm methods for handling missing values. Estimates of mean vector and variance–covariance matrix from the treated data set are used to build the multivariate exponentially weighted moving average (MEWMA) control chart. Based on a Monte Carlo simulation study, the performance of each of the five methods is investigated in terms of its ability to obtain the nominal in-control and out-of-control average run length (ARL). We consider three sample sizes, five levels of the percentage of missing values, and three types of variable numbers. Our simulation results show that imputation methods produce better performance than case deletion methods. The regression-based imputation methods have the best overall performance among all the competing methods.     

Multivariate Control Charts Based on Hybrid Novelty Scores

We propose a new nonparametric multivariate control chart that integrates a novelty score. The proposed control chart uses as its monitoring statistic a hybrid novelty score, calculated based on the distance to local observations as well as on the distance to the convex hull constructed by its neighbors. The control limits of the proposed control chart were established based on a bootstrap method. A rigorous simulation study was conducted to examine the properties of the proposed control chart under various scenarios and compare it with existing multivariate control charts in terms of average run length (ARL) performance. The simulation results showed that the proposed control chart outperformed both the parametric and nonparametric Hotelling's T ² control charts, especially in nonnormal situations. Moreover, experimental results with real semiconductor data demonstrated the applicability and effectiveness of the proposed control chart. To increase the capability to detect small mean shift, we propose an exponentially weighted hybrid novelty score control chart. Simulation results indicated that exponentially weighted hybrid score charts outperformed the hybrid novelty score based control charts.     

On a statistic useful in dimensionality reduction in multivariable linear stochastic system

In this paper we study the sampling properties of a test statistic which has important applications in the area of linear stochastic control systems with multi-inputs and multi-outputs. The statistic is the ratio of a partial sum of the eigenvalues of a sample covariance matrix and its trace. It turns out that using a method due to Sugiura we may derive a useful approximation for its distribution up to and including terms of order l/n, where n denotes the appropriate size. Numerical illustrations using real data are given.