Sample size re‐estimation incorporating prior information on a nuisance parameter

Prior information is often incorporated informally when planning a clinical trial. Here, we present an approach on how to incorporate prior information, such as data from historical clinical trials, into the nuisance parameter–based sample size re‐estimation in a design with an internal pilot study. We focus on trials with continuous endpoints in which the outcome variance is the nuisance parameter. For planning and analyzing the trial, frequentist methods are considered. Moreover, the external information on the variance is summarized by the Bayesian meta‐analytic‐predictive approach. To incorporate external information into the sample size re‐estimation, we propose to update the meta‐analytic‐predictive prior based on the results of the internal pilot study and to re‐estimate the sample size using an estimator from the posterior. By means of a simulation study, we compare the operating characteristics such as power and sample size distribution of the proposed procedure with the traditional sample size re‐estimation approach that uses the pooled variance estimator. The simulation study shows that, if no prior‐data conflict is present, incorporating external information into the sample size re‐estimation improves the operating characteristics compared to the traditional approach. In the case of a prior‐data conflict, that is, when the variance of the ongoing clinical trial is unequal to the prior location, the performance of the traditional sample size re‐estimation procedure is in general superior, even when the prior information is robustified. When considering to include prior information in sample size re‐estimation, the potential gains should be balanced against the risks.     

信息化进程中建设工程监理存在的问题及其解决对策

当前,工程监理业需要信息技术这一新兴手段对工程全程进行有效监管。在实际应用中,如何应用信息化手段实施监理,保障工程效果,实现信息化工程建设的高成功率,是工程建设相关方都极为关注的焦点。文章主要探讨信息化进程中建设工程监理存在的问题及解决对策,以期能更好地推动信息化建设在建设工程监理中的发展与应用,降低工程风险。     

超长钢板桩围堰合理内支撑施工方案

钢板桩围堰合理的内支撑施工方案对施工安全、工期长短、成本大小均有一定的影响。以阜阳至六安铁路颍河特大桥深水基础超长钢板桩围堰施工实践为例，通过建立钢板桩、内支撑和土层相互作用的三维整体有限元模型，根据封底混凝土施工时机的不同，选择4种施工方案，对超长钢板桩围堰内支撑施工方案进行了探讨。结果表明：封底混凝土施工越早，对围堰结构的整体安全越有利；实际采用的施工方案要根据桥址处工程地质条件，结合实际工程情况，经方案比选和分析论证以后确定。     

发达国家对华输出电子废弃物的环境影响与对策

近年来,发达国家电子废弃物的流入给发展中国家的环境和民众健康带来了严重的危害。我国在阻止电子废弃物流入的相关法律规制与监管上存在漏洞,且经济发展战略不合理,发展水平相对落后。法律和经济方面的双重落差导致发达国家电子废弃物流入屡禁不止,迫切需要采取有效措施加以应对。分析国外电子废弃物涌入我国之现状与原因,并从法律制度建设、经济发展思路、经济发展战略、国内管理和国际合作5方面提出应对策略。     

Support for midwives – A model of professional supervision based on the recertification programme for midwives in New Zealand

Following a traumatic practice experience the physiological and psychological effects experienced by midwives are exacerbated as a result of dysfunctional health organisations and the counterproductive behaviours therein. It is suggested the stress experienced would have been reduced if support in the form of professional supervision had been available.The aim of this article is to demonstrate that professional supervision should be viewed as a competency requirement by the Midwifery Council of New Zealand and incorporated into the midwifery recertification programme. A model of professional supervision for midwives based on the recertification programme is introduced and the importance of reflection on practice emphasised. Providing support by means of professional supervision in the midwifery recertification programme, has the potential to make midwives feel valued, improve their job satisfaction, reduce violence in the workplace, aid in the attrition rate and improve the care for the childbearing woman.     

地下钱庄行为的定性与防控——刑法与经济法互动的视角

地下钱庄并非规范的法律概念，我国对地下钱庄法律价值的判断是基于其组织的非正规性而非其行为的违法性，对地下钱庄行为更多地是借助刑法规制和执法严惩而非制度规范和监管指引。以刑法与经济法互动为视角，对地下钱庄所从事的三类主要业务进行具体分析，对相关法律法规予以细致梳理和客观评价，并结合我国金融生态环境和地下钱庄行为特点提出相应的立法建议和防控对策。提出在治理地下钱庄的过程中应当做到经济法规制在前、刑法惩治在后，监管在前、执法在后，宽严相济、疏堵结合。     

法治视野下科研事业单位国有资产监管体制的风险拷问

科研事业单位的国有资产,不能因其资产的非生产性、无偿使用性、公共利益性就脱离法律监管的视域,因为法治精神意味着法律权威在监管主体和监管对象之间要建立约束与契约关系,故而以法治精神为参考坐标,可以清楚地认识到当前我国的科研事业单位国有资产监管体制存在着诸多漏洞和风险。     

建设工程内部承包合同司法适用问题探究——以审判实践的冲突为样本

建设工程内部承包合同的效力究竟应当如何认定、在内部承包形式下具有怎样的对内对外效力、实际承包人与发包人或者第三方出现的纠纷应当如何进行解决等,在司法领域莫衷一是.内部承包合同,调整的是双方基本劳动报酬外的经营性利益分配关系.规范的内部承包合同并不同于转包合同或挂靠经营.虽然现有法条在某种征表下似乎是对内部承包合同作出了禁止性的规定,但是如果对法条进行体系的理解与整体的解读,内部承包合同并非属于当然禁止的范围     

“内”“外”表达:桂林龙脊梯田景区乡愁意识的建构与重塑

桂林龙脊梯田的农耕文明和乡土文化是自然景观与乡愁旅游资源的综合体,承载着景区的历史记忆,是延续和传承龙脊梯田景区乡愁文化的重要表征。留住乡愁文化对于传承当地的历史文化、重塑乡愁记忆和树立乡土文化自信具有重要作用。村民作为龙脊梯田景区乡愁旅游感知的内部视野,与作为外部视角的政府、游客和媒体有着不一样的建构策略,在深描各行动者如何"留住"与"重塑"乡愁的基础上,提出活化社会记忆、激发集体记忆、凝聚情感记忆和赋能媒介记忆的乡愁旅游发展路径,旨在强化乡愁旅游主体地位、增强乡愁文化认同、搭建乡愁情感纽带和创新乡愁文化感知。     

政府监管与企业加入第三方国际环境审计的模糊博弈分析

针对政府环境监管与企业实施环境行为博弈分析中无法对双方的损益情况做出判断的问题,文章结合三角模糊数构建了政府监管和企业加入第三方国际环境审计的博弈模型,分别指出了纯策略纳什均衡和混合策略均衡情况需要满足的条件,讨论了政府与污染环境企业博弈策略的影响因素及作用机制,为政府监管与企业加入第三方国际环境审计顺利实施提供了相关建议。然后通过三角结构元方法对算例进行求解,验证了结论的正确性和可行性,引入三角模糊概念更加符合实际应用情况,拓展了第三方国际环境审计的应用背景。研究结果表明,政府对消费者消费的引导和对污染企业的惩罚对企业是否决定加入第三方国际环境审计起着举足轻重的作用。