Estimation of the additive hazards model with interval-censored data and missing covariates

The additive hazards model is one of the most commonly used regression models in the analysis of failure time data and many methods have been developed for its inference in various situations. However, no established estimation procedure exists when there are covariates with missing values and the observed responses are interval-censored; both types of complications arise in various settings including demographic, epidemiological, financial, medical and sociological studies. To address this deficiency, we propose several inverse probability weight-based and reweighting-based estimation procedures for the situation where covariate values are missing at random. The resulting estimators of regression model parameters are shown to be consistent and asymptotically normal. The numerical results that we report from a simulation study suggest that the proposed methods work well in practical situations. An application to a childhood cancer survival study is provided. The Canadian Journal of Statistics 48: 499–517; 2020 © 2020 Statistical Society of Canada     

Correlation properties of continuous-time autoregressive processes delayed by the inverse of the stable subordinator

Abstract

We define the delayed Lévy-driven continuous-time autoregressive process via the inverse of the stable subordinator. We derive correlation structure for the observed non-stationary delayed Lévy-driven continuous-time autoregressive processes of order p, emphasizing low orders, and we show they exhibit long-range dependence property. Distributional properties are discussed as well.     

Regression analysis of case-cohort studies in the presence of dependent interval censoring

The case-cohort design is widely used as a means of reducing the cost in large cohort studies, especially when the disease rate is low and covariate measurements may be expensive, and has been discussed by many authors. In this paper, we discuss regression analysis of case-cohort studies that produce interval-censored failure time with dependent censoring, a situation for which there does not seem to exist an established approach. For inference, a sieve inverse probability weighting estimation procedure is developed with the use of Bernstein polynomials to approximate the unknown baseline cumulative hazard functions. The proposed estimators are shown to be consistent and the asymptotic normality of the resulting regression parameter estimators is established. A simulation study is conducted to assess the finite sample properties of the proposed approach and indicates that it works well in practical situations. The proposed method is applied to an HIV/AIDS case-cohort study that motivated this investigation.     

Enriching Surveys with Supplementary Data and its Application to Studying Wage Regression

We consider the problem of supplementing survey data with additional information from a population. The framework we use is very general; examples are missing data problems, measurement error models and combining data from multiple surveys. We do not require the survey data to be a simple random sample of the population of interest. The key assumption we make is that there exists a set of common variables between the survey and the supplementary data. Thus, the supplementary data serve the dual role of providing adjustments to the survey data for model consistencies and also enriching the survey data for improved efficiency. We propose a semi‐parametric approach using empirical likelihood to combine data from the two sources. The method possesses favourable large and moderate sample properties. We use the method to investigate wage regression using data from the National Longitudinal Survey of Youth Study.     

A Study of Interval Censoring in Parametric Regression Models

Parametric models for interval censored data can now easily be fitted with minimal programming in certain standard statistical software packages. Regression equations can be introduced, both for the location and for the dispersion parameters. Finite mixture models can also be fitted, with a point mass on right (or left) censored observations, to allow for individuals who cannot have the event (or already have it). This mixing probability can also be allowed to follow a regression equation.Here, models based on nine different distributions are compared for three examples of heavily censored data as well as a set of simulated data. We find that, for parametric models, interval censoring can often be ignored and that the density, at centres of intervals, can be used instead in the likelihood function, although the approximation is not always reliable. In the context of heavily interval censored data, the conclusions from parametric models are remarkably robust with changing distributional assumptions and generally more informative than the corresponding non-parametric models.     

Toeplitz矩阵的性质及其应用

运用矩阵方法,研究了特殊的Toeplitz矩阵A和n阶幂零矩阵在相似变换下的广义逆,得到了Toeplitz矩阵的一些性质,并用这些性质刻画了幂零矩阵A在相似变换下的广义逆的表达形式.     

Remove unwanted variation retrieves unknown experimental designs

Remove unwanted variation (RUV) is an estimation and normalization system in which the underlying correlation structure of a multivariate dataset is estimated from negative control measurements, typically gene expression values, which are assumed to stay constant across experimental conditions. In this paper we derive the weight matrix which is estimated and incorporated into the generalized least squares estimates of RUV-inverse, and show that this weight matrix estimates the average covariance matrix across negative control measurements. RUV-inverse can thus be viewed as an estimation method adjusting for an unknown experimental design. We show that for a balanced incomplete block design (BIBD), RUV-inverse recovers intra- and interblock estimates of the relevant parameters and combines them as a weighted sum just like the best linear unbiased estimator (BLUE), except that the weights are globally estimated from the negative control measurements instead of being individually optimized to each measurement as in the classical, single measurement BIBD BLUE.     

Bayesian and likelihood inference for cure rates based on defective inverse Gaussian regression models

Failure time models are considered when there is a subpopulation of individuals that is immune, or not susceptible, to an event of interest. Such models are of considerable interest in biostatistics. The most common approach is to postulate a proportion p of immunes or long-term survivors and to use a mixture model [5]. This paper introduces the defective inverse Gaussian model as a cure model and examines the use of the Gibbs sampler together with a data augmentation algorithm to study Bayesian inferences both for the cured fraction and the regression parameters. The results of the Bayesian and likelihood approaches are illustrated on two real data sets.     

Analysis of covariance under inverse Gaussian model

This paper considers the problem of analysis of covariance (ANCOVA) under the assumption of inverse Gaussian distribution for response variable. We develop the essential methodology for estimating the model parameters via maximum likelihood method. The general form of the maximum likelihood estimator is obtained in color closed form. Adjusted treatment effects and adjusted covariate effects are given, too. We also provide the asymptotic distribution of the proposed estimators. A simulation study and a real world application are also performed to illustrate and evaluate the proposed methodology.