Relative Potency Estimation in Parallel-Line Assays – Method Comparison and Some Extensions

Relative potency estimations in both multiple parallel-line and slope-ratio assays involve construction of simultaneous confidence intervals for ratios of linear combinations of general linear model parameters. The key problem here is that of determining multiplicity adjusted percentage points of a multivariate t-distribution, the correlation matrix R of which depends on the unknown relative potency parameters. Several methods have been proposed in the literature on how to deal with R . In this article, we introduce a method based on an estimate of R (also called the plug-in approach) and compare it with various methods including conservative procedures based on probability inequalities. Attention is restricted to parallel-line assays though the theory is applicable for any ratios of coefficients in the general linear model. Extension of the plug-in method to linear mixed effect models is also discussed. The methods will be compared with respect to their simultaneous coverage probabilities via Monte Carlo simulations. We also evaluate the methods in terms of confidence interval width through application to data on multiple parallel-line assay.     

Asymptotic Properties of Random Weighted Empirical Distribution Function

This article studies the asymptotic properties of the random weighted empirical distribution function of independent random variables. Suppose X₁, X₂, ???, X_n is a sequence of independent random variables, and this sequence is not required to be identically distributed. Denote the empirical distribution function of the sequence by F_n(x). Based on the random weighting method and F_n(x), the random weighted empirical distribution function H_n(x) is constructed and the asymptotic properties of H_n are discussed. Under weak conditions, the Glivenko–Cantelli theorem and the central limit theorem for the random weighted empirical distribution function are obtained. The obtained results have also been applied to study the distribution functions of random errors of multiple sensors.     

Approximation to Multifractional Riemann-Liouville Brownian Sheet

In this article, we first introduce multifrational Riemann-Liouville Brownian sheets. Then, we show a result of approximation in law of the multifractional Riemann-Liouville Brownian sheet. The construction of these approximations is based on a sequence of I.I.D random variables.     

Testing the difference between two independent regression models

ABSTRACT

In some situations, for example, in biology or psychology studies, we wish to determine whether the linear relationship between response variable and predictor variables differs in two populations. The analysis of the covariance (ANCOVA) or, equivalently, the partial F-test approaches are the commonly used methods. In this study, the asymptotic distribution for the difference between two independent regression coefficients was established. The proposed method was used to derive the asymptotic confidence set for the difference between coefficients and hypothesis testing for the equality of the two regression models. Then a simulation study was conducted to compare the proposed method with the partial F method. The performance of the new method was comparable with that of the partial F method.     

An extension of almost sure central limit theorem for self-normalized products of sums for mixing sequences

ABSTRACT

Let X, X₁, X₂, … be a sequence of strictly stationary φ-mixing random variables with EX = μ > 0. In this paper, we show that a self-normalized version of almost sure central limit theorem (ASCLT) holds under the assumptions that the mixing coefficients satisfy ∑^∞_{n = 1}φ^1/2(2ⁿ) < ∞ and the weight sequence {d_k} satisfies a mild growth condition similar to Kolmogorov’s condition for the LIL. This shows that logarithmic averages, used traditionally in ASCLT for products of sums, can be replaced by other averages, leading to considerably sharper results.     

Invariance principles and almost sure central limit theorem for the error variance estimator in linear models

A number of score statistics are derived for a heterogeneous spatial Poisson process which has a composite intensity. The intensity consists of a 'background' process which is estimated

from a control point process by kernel density estimation. The parametric form of the composite intensity yields score tests for particular spatial effects. A numerical example concerning respiratory cancer mortality is given.     

On the effect of long-range dependence on extreme value copula estimation with fixed marginals

ABSTRACT

We establish the existence of multivariate stationary processes with arbitrary marginal copula distributions and long-range dependence. The effect of long-range dependence on extreme value copula estimation is illustrated in the case of known marginals, by deriving functional limit theorems for a standard non parametric estimator of the Pickands dependence function and related parametric projection estimators. The asymptotic properties turn out to be very different from the case of iid or short-range dependent observations. Simulated and real data examples illustrate the results.     

A class of small deviation theorems for the random variables associated with mth-order asymptotic circular Markov chains

ABSTRACT

In this article, we study a class of small deviation theorems for the random variables associated with mth-order asymptotic circular Markov chains. First, the definition of mth-order asymptotic circular Markov chain is introduced, then by applying the known results of the limit theorem for mth-order non homogeneous Markov chain, the small deviation theorem on the frequencies of occurrence of states for mth-order asymptotic circular Markov chains is established. Next, the strong law of large numbers and asymptotic equipartition property for this Markov chains are obtained. Finally, some results of mth-order nonhomogeneous Markov chains are given.     

AN application of a crossing probability bound to population biology

This paper addresses the problem of detecting natural boundaries in a geographical region containing a large number of animal species, A statistical test of a "no boundary" hypothesis based on Sokal's matching coefficient is derived using a level crossing probability bound for discrete Gaussian random fields after establishing the legitimacy of the Gaussian assumption by a central limit theorem.