A structured brain‐wide and genome‐wide association study using ADNI PET images

A multistage variable selection method is introduced for detecting association signals in structured brain‐wide and genome‐wide association studies (brain‐GWAS). Compared to conventional methods that link one voxel to one single nucleotide polymorphism (SNP), our approach is more efficient and powerful in selecting the important signals by integrating anatomic and gene grouping structures in the brain and the genome, respectively. It avoids resorting to a large number of multiple comparisons while effectively controlling the false discoveries. Validity of the proposed approach is demonstrated by both theoretical investigation and numerical simulations. We apply our proposed method to a brain‐GWAS using Alzheimer's Disease Neuroimaging Initiative positron emission tomography (ADNI PET) imaging and genomic data. We confirm previously reported association signals and also uncover several novel SNPs and genes that are either associated with brain glucose metabolism or have their association significantly modified by Alzheimer's disease status.     

Designing of a mixed-chain sampling plan based on the process capability index with chain sampling as the attributes plan

In this article, we propose a new mixed chain sampling plan based on the process capability index C_pk, where the quality characteristic of interest having double specification limits and follows the normal distribution with unknown mean and variance. In the proposed mixed plan, the chain sampling inspection plan is used for the inspection of attribute quality characteristics. The advantages of this proposed mixed sampling plan are also discussed. Tables are constructed to determine the optimal parameters for practical applications by formulating the problem as a non linear programming in which the objective function to be minimized is the average sample number and the constraints are related to lot acceptance probabilities at acceptable quality level and limiting quality level under the operating characteristic curve. The practical application of the proposed mixed sampling plan is explained with an illustrative example. Comparison of the proposed sampling plan is also made with other existing sampling plans.     

Concomitant record ranked set sampling

In this work, we define a new method of ranked set sampling (RSS) which is suitable when the characteristic (variable) Y of primary interest on the units is jointly distributed with an auxiliary characteristic X on which one can take its measurement on any number of units, so that units having record values on X alone are ranked and retained for making measurement on Y. We name this RSS as concomitant record ranked set sampling (CRRSS). We propose estimators of the parameters associated with the variable Y of primary interest based on observations of the proposed CRRSS which are applicable to a very large class of distributions viz. Morgenstern family of distributions. We illustrate the application of CRRSS and our estimation technique of parameters, when the basic distribution is Morgenstern-type bivariate logistic distribution. A primary data collected by CRRSS method is demonstrated and the obtained data used to illustrate the results developed in this work.     

Nonparametric Estimation and Forecasting for Time-Varying Coefficient Realized Volatility Models

This article introduces a new specification for the heterogenous autoregressive (HAR) model for the realized volatility of S&P 500 index returns. In this modeling framework, the coefficients of the HAR are allowed to be time-varying with unspecified functional forms. The local linear method with the cross-validation (CV) bandwidth selection is applied to estimate the time-varying coefficient HAR (TVC-HAR) model, and a bootstrap method is used to construct the point-wise confidence bands for the coefficient functions. Furthermore, the asymptotic distribution of the proposed local linear estimators of the TVC-HAR model is established under some mild conditions. The results of the simulation study show that the local linear estimator with CV bandwidth selection has favorable finite sample properties. The outcomes of the conditional predictive ability test indicate that the proposed nonparametric TVC-HAR model outperforms the parametric HAR and its extension to HAR with jumps and/or GARCH in terms of multi-step out-of-sample forecasting, in particular in the post-2003 crisis and 2007 global financial crisis (GFC) periods, during which financial market volatilities were unduly high.     

Performance analysis of the preliminary test estimator with series of stochastic restrictions

In this paper, the problem of estimation of the regression coefficients in a multiple regression model is considered under the multicollinearity situation when there are series of stochastic linear restrictions available on the regression parameter vector. We have considered the preliminary test ridge regression estimators (PTRREs) based on the Wald, likelihood ratio, and lagrangian multiplier tests. Tables for the maximum and minimum guaranteed efficiency of the PTRREs are obtained, which allow us to determine the optimum choice of the level of significance corresponding to the optimum estimator. Some numerical results support the findings.     

On convergence rate in the SLLN for maximums of moving-average sums of ALNQD random fields

In this article, we define a notion of asymptotically linear negatively quadrant dependence and establish the rate of complete convergence for maximums of moving-average sums of asymptotically linear negatively quadrant dependent random fields.     

Randomized quantile regression estimation for heteroskedastic non parametric model

In this paper, we propose robust randomized quantile regression estimators for the mean and (condition) variance functions of the popular heteroskedastic non parametric regression model. Unlike classical approaches which consider quantile as a fixed quantity, our method treats quantile as a uniformly distributed random variable. Our proposed method can be employed to estimate the error distribution, which could significantly improve prediction results. An automatic bandwidth selection scheme will be discussed. Asymptotic properties and relative efficiencies of the proposed estimators are investigated. Our empirical results show that the proposed estimators work well even for random errors with infinite variances. Various numerical simulations and two real data examples are used to demonstrate our methodologies.     

Robust estimation for partially linear single-index model

In this article, we investigate a new estimation approach for the partially linear single-index model based on modal regression method, where the non parametric function is estimated by penalized spline method. Moreover, we develop an expection maximum (EM)-type algorithm and establish the large sample properties of the proposed estimation method. A distinguishing characteristic of the newly proposed estimation is robust against outliers through introducing an additional tuning parameter which can be automatically selected using the observed data. Simulation studies and real data example are used to evaluate the finite-sample performance, and the results show that the newly proposed method works very well.     

Quasi-likelihood Bridge estimators for high-dimensional generalized linear models

In this article, we consider the variable selection and estimation for high-dimensional generalized linear models when the number of parameters diverges with the sample size. We propose a penalized quasi-likelihood function with the bridge penalty. The consistency and the Oracle property of the quasi-likelihood bridge estimators are obtained. Some simulations and a real data analysis are given to illustrate the performance of the proposed method.