Estimation of relaxation time distributions in magnetic resonance imaging

Magnetic resonance imaging techniques can be used to measure some biophysical properties of tissue. In this context, the T₂ relaxation time is an important parameter for soft‐tissue contrast. The authors develop a new technique to estimate the integral of the distribution of T₂ relaxation time without imposing any constraint other than the monotonicity of the underlying cumulative relaxation time distribution. They explore the properties of the estimation and its applications for the analysis of breast tissue data. As they show, an extension of linear discriminant analysis is found to distinguish well between two classes of breast tissue.     

Estimation under modified Weibull distribution based on right censored generalized order statistics

In this paper, the maximum likelihood (ML) and Bayes, by using Markov chain Monte Carlo (MCMC), methods are considered to estimate the parameters of three-parameter modified Weibull distribution (MWD(β, τ, λ)) based on a right censored sample of generalized order statistics (gos). Simulation experiments are conducted to demonstrate the efficiency of the proposed methods. Some comparisons are carried out between the ML and Bayes methods by computing the mean squared errors (MSEs), Akaike's information criteria (AIC) and Bayesian information criteria (BIC) of the estimates to illustrate the paper. Three real data sets from Weibull(α, β) distribution are introduced and analyzed using the MWD(β, τ, λ) and also using the Weibull(α, β) distribution. A comparison is carried out between the mentioned models based on the corresponding Kolmogorov–Smirnov (K–S) test statistic, {AIC and BIC} to emphasize that the MWD(β, τ, λ) fits the data better than the other distribution. All parameters are estimated based on type-II censored sample, censored upper record values and progressively type-II censored sample which are generated from the real data sets.     

Questions and Answers

In addition to his contributions to biostatistics and clinical trials, Paul Meier had a long-term interest in the legal applications of statistics. As part of this, he had extensive experience as a statistical consultant. Legal consulting can be a minefield, but as a result of his background, Paul had excellent advice to give to those starting out on how to function successfully in this environment.     

Extended BIC for linear regression models with diverging number of relevant features and high or ultra-high feature spaces

In many conventional scientific investigations with high or ultra-high dimensional feature spaces, the relevant features, though sparse, are large in number compared with classical statistical problems, and the magnitude of their effects tapers off. It is reasonable to model the number of relevant features as a diverging sequence when sample size increases. In this paper, we investigate the properties of the extended Bayes information criterion (EBIC) (Chen and Chen, 2008) for feature selection in linear regression models with diverging number of relevant features in high or ultra-high dimensional feature spaces. The selection consistency of the EBIC in this situation is established. The application of EBIC to feature selection is considered in a SCAD cum EBIC procedure. Simulation studies are conducted to demonstrate the performance of the SCAD cum EBIC procedure in finite sample cases.     

Power-divergence-type measure of departure from diagonals-parameter symmetry for square contingency tables with ordered categories

For the analysis of square contingency tables with ordered categories, Goodman considered the diagonals-parameter symmetry (DPS) model. This paper proposes a measure to represent the degree of departure from the DPS model. The proposed measure is expressed by applying Read and Cressie’s power-divergence or Patil and Taillie’s diversity index. The measure would be useful for comparing the degree of departure from the DPS model in several tables. Examples are given.     

Variance bounds for estimators in autoregressive models with constraints

We consider nonlinear and heteroscedastic autoregressive models whose residuals are martingale increments with conditional distributions that fulfil certain constraints. We treat two classes of constraints: residuals depending on the past through some function of the past observations only, and residuals that are invariant under some finite group of transformations. We determine the efficient influence function for estimators of the autoregressive parameter in such models, calculate variance bounds, discuss information gains, and suggest how to construct efficient estimators. Without constraints, efficient estimators can be given by weighted least squares estimators. With the constraints considered here, efficient estimators are obtained differently, as one-step improvements of some initial estimator, similarly as in autoregressive models with independent increments.     

Further results for parallel systems with two heterogeneous exponential components

In this paper, we investigate ordering properties of lifetimes of parallel systems with two independent heterogeneous exponential components with respect to likelihood ratio and hazard rate orders. Two sufficient conditions are provided for likelihood ratio and hazard rate orders to hold between the lifetimes of two parallel systems, respectively. Moreover, we extend the results from exponential case to the proportional hazard rate models. The results established here strength some of the results known in the literature. Finally, some numerical examples are given to illustrate the theoretical results derived here as well.     

Kullback–Leibler information of a censored variable and its applications

In this paper, we study the Kullback–Leibler (KL) information of a censored variable, which we will simply call it censored KL information. The censored KL information is shown to have the necessary monotonicity property in addition to inherent properties of nonnegativity and characterization. We also present a representation of the censored KL information in terms of the relative risk and study its relation with the Fisher information in censored data. Finally, we evaluate the estimated censored KL information as a goodness-of-fit test statistic.     

Analysis of hybrid censored competing risks data

In this paper, we consider the analysis of hybrid censored competing risks data, based on Cox's latent failure time model assumptions. It is assumed that lifetime distributions of latent causes of failure follow Weibull distribution with the same shape parameter, but different scale parameters. Maximum likelihood estimators (MLEs) of the unknown parameters can be obtained by solving a one-dimensional optimization problem, and we propose a fixed-point type algorithm to solve this optimization problem. Approximate MLEs have been proposed based on Taylor series expansion, and they have explicit expressions. Bayesian inference of the unknown parameters are obtained based on the assumption that the shape parameter has a log-concave prior density function, and for the given shape parameter, the scale parameters have Beta–Gamma priors. We propose to use Markov Chain Monte Carlo samples to compute Bayes estimates and also to construct highest posterior density credible intervals. Monte Carlo simulations are performed to investigate the performances of the different estimators, and two data sets have been analysed for illustrative purposes.     

Skew-normal alpha-power model

In this paper, authors study properties and inference for the newly introduced skew-normal alpha-power model, generalizing both, the power-normal and skew-normal models. Inference is approached via maximum likelihood. Fisher information matrix is derived and shown to be nonsingular at the whole parametric space. Special emphasis is placed on the special case of the power–skew-normal model. Studies with real data illustrate the fact that the model can be very useful in applications, being able to overfit less general models entertained in the literature.