Bayesian inference for a discretely observed stochastic kinetic model

The ability to infer parameters of gene regulatory networks is emerging as a key problem in systems biology. The biochemical data are intrinsically stochastic and tend to be observed by means of discrete-time sampling systems, which are often limited in their completeness. In this paper we explore how to make Bayesian inference for the kinetic rate constants of regulatory networks, using the stochastic kinetic Lotka-Volterra system as a model. This simple model describes behaviour typical of many biochemical networks which exhibit auto-regulatory behaviour. Various MCMC algorithms are described and their performance evaluated in several data-poor scenarios. An algorithm based on an approximating process is shown to be particularly efficient.     

教育服务产出核算分析

教育服务是服务核算中的一个重要部分。本文讨论教育服务的定义和服务产出的数量单位。研究教育服务的核算范围和计算教育服务产出价值的方法,以及教育服务的质量调整问题。最后,举例使用产出指标方法计算教育产出。     

荷兰居民生活质量调查方法研究及对中国的启示

通过对荷兰居民生活质量调查方法的研究，旨在分析总结其值得借鉴之处，并在此基础上针对中国正在探索中的居民生活质量调查，提出构建中国居民生活质量调查体系应拓宽其调查信息来源、实现数据共享、积极提高回应率、培养高素质调查队伍以及定期发布调查报告。     

工程制图课程体系和教学方法改革的思路与实践

在阐述工程制图课程重要和特殊地位的基础上 ,概括指出了目前我国工程制图课程改革的三种教学模式 ,并列举了国外部分院校课程改革的实例 ,总结出教改共识。在明确课程改革基本思想的前提下 ,具体提出课程改革的总体思路和实践过程 :整合课程内容 ,形成新的课程体系 ,构建基础平台 ;改革教学手段 ,更新教学方法 ,保证教学质量 ,提高教学效率     

《读书人是幸福人》说课设计

说课,是检验教师教学基本功的手段之一,它不同于一般的发言稿和课堂教学,它要求说者比较系统地介绍自己的教学设计及其理论依据(包括大纲依据、课程标准依据、教学法依据、教育学和心理学依据等),而不是宣讲教案,也不是浓缩课堂。它的核心在于说理,在于说清为什么要这样教,用什么理论来支持教学,说课的重点在于教学重点和教学难点的突破上。说案不同于教案。     

Analytical approximations for iterated bootstrap confidence intervals

Standard algorithms for the construction of iterated bootstrap confidence intervals are computationally very demanding, requiring nested levels of bootstrap resampling. We propose an alternative approach to constructing double bootstrap confidence intervals that involves replacing the inner level of resampling by an analytical approximation. This approximation is based on saddlepoint methods and a tail probability approximation of DiCiccio and Martin (1991). Our technique significantly reduces the computational expense of iterated bootstrap calculations. A formal algorithm for the construction of our approximate iterated bootstrap confidence intervals is presented, and some crucial practical issues arising in its implementation are discussed. Our procedure is illustrated in the case of constructing confidence intervals for ratios of means using both real and simulated data. We repeat an experiment of Schenker (1985) involving the construction of bootstrap confidence intervals for a variance and demonstrate that our technique makes feasible the construction of accurate bootstrap confidence intervals in that context. Finally, we investigate the use of our technique in a more complex setting, that of constructing confidence intervals for a correlation coefficient.     

CO_2增加与未来气温变化

近几十年来．由于人类活动导致大气中ＣＯ２含量呈明显上升趋势，预计到下世纪中叶ＣＯ２浓度将达到４５０ｐｐｍ左右，下世纪末，将达到工业革命前的两倍，各种数值模式表明，届时全球气温将升高１．５－４．５℃。     

最优验血方法的判定

本文对Ｎ个人验血的检验方法进行研究．得到如下结果：（１）设普查对象的阳性概率为ｐ，对当时，采用分组检验最优；当ｐ≥０．３０７８时，采用单个检验最优、（２）当采用分组检验时，分组人数或时，检验次数最少．     

治疗腰痛的气功功法和功理

本文扼要论述腰痛治疗三个层次的气功功法和功理.