Inference in Targeted Group‐Sequential Covariate‐Adjusted Randomized Clinical Trials

This article is devoted to the construction and asymptotic study of adaptive, group‐sequential, covariate‐adjusted randomized clinical trials analysed through the prism of the semiparametric methodology of targeted maximum likelihood estimation. We show how to build, as the data accrue group‐sequentially, a sampling design that targets a user‐supplied optimal covariate‐adjusted design. We also show how to carry out sound statistical inference based on such an adaptive sampling scheme (therefore extending some results known in the independent and identically distributed setting only so far), and how group‐sequential testing applies on top of it. The procedure is robust (i.e. consistent even if the working model is mis‐specified). A simulation study confirms the theoretical results and validates the conjecture that the procedure may also be efficient.     

A frequency domain comparison of estimation methods for gaussian fields

This paper demonstrates that well-known parameter estimation methods for Gaussian fields place different emphasis on the high and low frequency components of the data. As a consequence, the relative importance of the frequencies under the objective of the analysis should be taken into account when selecting an estimation method, in addition to other considerations such as statistical and computational efficiency. The paper also shows that when noise is added to the Gaussian field, maximum pseudolikelihood automatically sets the smoothing parameter of the model equal to one. A simulation study then indicates that generalised cross-validation is more robust than maximum likelihood un-

der model misspecification in smoothing and image restoration problems. This has implications for Bayesian procedures since these use the same weightings of the frequencies as the likelihood.     

Estimating survival curves with left truncated and interval censored data via the ems algorithm

It is well-known that the nonparametric maximum likelihood estimator (NPMLE) of a survival function may severely underestimate the survival probabilities at very early times for left truncated data. This problem might be overcome by instead computing a smoothed nonparametric estimator (SNE) via the EMS algorithm. The close connection between the SNE and the maximum penalized likelihood estimator is also established. Extensive Monte Carlo simulations demonstrate the superior performance of the SNE over that of the NPMLE, in terms of either bias or variance, even for moderately large Samples. The methodology is illustrated with an application to the Massachusetts Health Care Panel Study dataset to estimate the probability of being functionally independent for non-poor male and female groups rcspectively.     

Geometric sample size determination in Bayesian analysis

The problem of sample size determination in the context of Bayesian analysis is considered. For the familiar and practically important parameter of a geometric distribution with a beta prior, three different Bayesian approaches based on the highest posterior density intervals are discussed. A computer program handles all computational complexities and is available upon request.     

A segmented regime-switching model with its application to stock market indices

This paper evaluates the ability of a Markov regime-switching log-normal (RSLN) model to capture the time-varying features of stock return and volatility. The model displays a better ability to depict a fat tail distribution as compared with using a log-normal model, which means that the RSLN model can describe observed market behavior better. Our major objective is to explore the capability of the model to capture stock market behavior over time. By analyzing the behavior of calibrated regime-switching parameters over different lengths of time intervals, the change-point concept is introduced and an algorithm is proposed for identifying the change-points in the series corresponding to the times when there are changes in parameter estimates. This algorithm for identifying change-points is tested on the Standard and Poor's 500 monthly index data from 1971 to 2008, and the Nikkei 225 monthly index data from 1984 to 2008. It is evident that the change-points we identify match the big events observed in the US stock market and the Japan stock market (e.g., the October 1987 stock market crash), and that the segmentations of stock index series, which are defined as the periods between change-points, match the observed bear–bull market phases.     

Testing the equality among distribution functions from independent and right censored samples via Cramér–von Mises criterion

The traditional Cramér–von Mises criterion is used in order to develop a test to compare the equality of the underlying lifetime distributions in the presence of independent censoring times. Its asymptotic distribution is proved and a resampling plan, which is valid for unbalanced data situations, is proposed. Its statistical power is studied and compared with commonly used linear rank tests by Monte Carlo simulations and a real data analysis is also considered. It is observed that the new test is clearly more powerful than the traditional ones when there exists no uniform dominance among involved distributions and in the presence of late differences. Its statistical power is also good in the other considered scenarios.     

On Calculations Involving the Maximum Cell Frequency

We describe a method of computing the cumulative distribution function of the maximum and minimum cell frequencies in sampling distributions commonly encountered in the analysis of categorical data.The procedure is efficient for exact or approximate calculation in both homogeneous and non-homogeneous cases, is non-recursive, and does not require Dirichlet integrals.Some related statistical problems are also discussed.     

Data-driven tests of uniformity on product manifolds

Data-driven versions of Sobolev tests of uniformity on compact Riemannian manifolds are reviewed and their large-sample asymptotic properties are given. A variant which is suitable for product manifolds is introduced. Data-driven goodness-of-fit tests of multivariate distributions are derived from data-driven tests of uniformity on tori.     

Multistate life‐tables and regression models

A survey is given of the use of modern statistical techniques in event history analysis, and in particular in the study of multi‐state life‐tables in demography. Emphasis is placed on the interplay between partial likelihood and nonparametric maximum likelihood based methods, a) when analysing semi‐Markov models or models with repeated spells, and b) in frailty models for inobservable heterogeneity.