Goodness-of-Fit Test and Parameter Estimation for a Proportional Odds Model of Random Censorship

Censored data arise naturally in a number of fields, particularly in problems of reliability and survival analysis. There are several types of censoring, in this article, we will confine ourselves to the right randomly censoring type. Recently, Ahmadi et al. (2010 Ahmadi , J. , Doostparast , M. , Parsian , A. ( 2010 ). Bayes estimation based on random censored data for some life time models under symmetric and asymmetric loss functions . Communcations in Statistics-Theory and Methods , 39 : 3058 – 3071 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) considered the problem of estimating unknown parameters in a general framework based on the right randomly censored data. They assumed that the survival function of the censoring time is free of the unknown parameter. This assumption is sometimes inappropriate. In such cases, a proportional odds (PO) model may be more appropriate (Lam and Leung, 2001 Lam , K. F. , Leung , T. L. ( 2001 ). Marginal likelihood estimation for proportional odds models with right censored data . Lifetime Data Analysis 7 : 39 – 54 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]). Under this model, in this article, point and interval estimations for the unknown parameters are obtained. Since it is important to check the adequacy of models upon which inferences are based (Lawless, 2003 Lawless , J. F. (2003). Statistical Models and Methods for Lifetime Data. , 2nd ed. New York : John Wiley & Sons. [Google Scholar], p. 465), two new goodness-of-fit tests for PO model based on right randomly censored data are proposed. The proposed procedures are applied to two real data sets due to Smith (2002 Smith , P. J. ( 2002 ). Analysis of Failure and Survival Data . London : Chapman & Hall, CRC . [Google Scholar]). A Monte Carlo simulation study is conducted to carry out the behavior of the estimators obtained.     

A Comparison of Approaches to Interval Estimation of Mediated Effects in Linear Regression Models

A novel approach based on the concepts of a generalized pivotal quantity (GPQ) is developed to construct confidence intervals for the mediated effect. Thereafter, its performance is compared with six interval estimation approaches in terms of empirical coverage probability and expected length via simulation and two real examples. The results show that the GPQ-based and bootstrap percentile methods outperform other methods when mediated effects exist in small and medium samples. Moreover, the GPQ-based method exhibits a more stable performance in small and non-normal samples. A discussion on how to choose the best interval estimation method for mediated effects is presented.     

Tuning Parameter Estimation in Penalized Least Squares Methodology

The efficiency of the penalized methods (Fan and Li, 2001 Fan , J. , Li , R. ( 2001 ). Variable selection via nonconcave penalized likelihood and its oracle properties . Journal of the American Statistical Association 96 : 1348 – 1360 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) depends strongly on a tuning parameter due to the fact that it controls the extent of penalization. Therefore, it is important to select it appropriately. In general, tuning parameters are chosen by data-driven approaches, such as the commonly used generalized cross validation. In this article, we propose an alternative method for the derivation of the tuning parameter selector in penalized least squares framework, which can lead to an ameliorated estimate. Simulation studies are presented to support theoretical findings and a comparison of the Type I and Type II error rates, considering the L ₁, the hard thresholding and the Smoothly Clipped Absolute Deviation penalty functions, is performed. The results are given in tables and discussion follows.     

Robustness and Corrections for Sample Size Adaptation Strategies Based on Effect Size Estimation

A study on the robustness of the adaptation of the sample size for a phase III trial on the basis of existing phase II data is presented—when phase III is lower than phase II effect size. A criterion of clinical relevance for phase II results is applied in order to launch phase III, where data from phase II cannot be included in statistical analysis. The adaptation consists in adopting the conservative approach to sample size estimation, which takes into account the variability of phase II data. Some conservative sample size estimation strategies, Bayesian and frequentist, are compared with the calibrated optimal γ conservative strategy (viz. COS) which is the best performer when phase II and phase III effect sizes are equal. The Overall Power (OP) of these strategies and the mean square error (MSE) of their sample size estimators are computed under different scenarios, in the presence of the structural bias due to lower phase III effect size, for evaluating the robustness of the strategies. When the structural bias is quite small (i.e., the ratio of phase III to phase II effect size is greater than 0.8), and when some operating conditions for applying sample size estimation hold, COS can still provide acceptable results for planning phase III trials, even if in bias absence the OP was higher.

Main results concern the introduction of a correction, which affects just sample size estimates and not launch probabilities, for balancing the structural bias. In particular, the correction is based on a postulation of the structural bias; hence, it is more intuitive and easier to use than those based on the modification of Type I or/and Type II errors. A comparison of corrected conservative sample size estimation strategies is performed in the presence of a quite small bias. When the postulated correction is right, COS provides good OP and the lowest MSE. Moreover, the OPs of COS are even higher than those observed without bias, thanks to higher launch probability and a similar estimation performance. The structural bias can therefore be exploited for improving sample size estimation performances. When the postulated correction is smaller than necessary, COS is still the best performer, and it also works well. A higher than necessary correction should be avoided.     

Estimation of Time-Varying Long Memory Parameter Using Wavelet Method

Stationary long memory processes have been extensively studied over the past decades. When we deal with financial, economic, or environmental data, seasonality and time-varying long-range dependence can often be observed and thus some kind of non-stationarity exists. To take into account this phenomenon, we propose a new class of stochastic processes: locally stationary k-factor Gegenbauer process. We present a procedure to estimate consistently the time-varying parameters by applying discrete wavelet packet transform. The robustness of the algorithm is investigated through a simulation study. And we apply our methods on Nikkei Stock Average 225 (NSA 225) index series.     

A Frailty Model in Crossover Studies with Time-to-Event Response Variable

In this article, we develop a model to study treatment, period, carryover, and other applicable effects in a crossover design with a time-to-event response variable. Because time-to-event outcomes on different treatment regimens within the crossover design are correlated for an individual, we adopt a proportional hazards frailty model. If the frailty is assumed to have a gamma distribution, and the hazard rates are piecewise constant, then the likelihood function can be determined via closed-form expressions. We illustrate the methodology via an application to a data set from an asthma clinical trial and run simulations that investigate sensitivity of the model to data generated from different distributions.     

Partially Accelerated Life Tests for the Weibull Distribution Under Multiply Censored Data

This article aims to estimate the parameters of the Weibull distribution in step-stress partially accelerated life tests under multiply censored data. The step partially acceleration life test is that all test units are first run simultaneously under normal conditions for a pre-specified time, and the surviving units are then run under accelerated conditions until a predetermined censoring time. The maximum likelihood estimates are used to obtaining the parameters of the Weibull distribution and the acceleration factor under multiply censored data. Additionally, the confidence intervals for the estimators are obtained. Simulation results show that the maximum likelihood estimates perform well in most cases in terms of the mean bias, errors in the root mean square and the coverage rate. An example is used to illustrate the performance of the proposed approach.     

Bayesian Estimation of Bivariate Exponential Distributions Based on Linex and Quadratic Loss Functions: A Survival Approach with Censored Samples

In this article, four bivariate exponential (BVE) distributions with subject to right censoring samples are presented. Bayesian estimates of the parameters of BVE are obtained through Linex and quadratic loss functions. Gamma prior distribution has been suggested to reforming the posterior function. The estimations and standard errors of parameters have also been obtained through simulation method. Markov chain Monte Carlo (MCMC) method is employed for the case of Block-Buse bivariate distribution because there was no closed form for estimator criteria. Simulation studies have been conducted to show that the computation parts can be implemented easily and comparing the estimated values due to two methods and with the true values as well.     

Variable Selection in Joint Location and Scale Models of the Skew-t-Normal Distribution

Variable selection is an important issue in all regression analysis, and in this article, we investigate the simultaneous variable selection in joint location and scale models of the skew-t-normal distribution when the dataset under consideration involves heavy tail and asymmetric outcomes. We propose a unified penalized likelihood method which can simultaneously select significant variables in the location and scale models. Furthermore, the proposed variable selection method can simultaneously perform parameter estimation and variable selection in the location and scale models. With appropriate selection of the tuning parameters, we establish the consistency and the oracle property of the regularized estimators. These estimators are compared by simulation studies.     

Reduced-Variance Methods for Detectability Correction of Population Abundance

Detectability issues create uncertainty in field surveys of animal and plant populations. Detectability correction is one method employed to deal with this problem when there is reasonable certainty that detectability is roughly constant with time or in different areas. Two new reduced-variance estimators of detectability are introduced and evaluated for the case of using a detectability correction for new areas that are surveyed only once. The new estimates are unbiased or nearly unbiased and produce population estimates with smaller variance than the Lincoln–Petersen estimate.