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71.
Since the implementation of the International Conference on Harmonization (ICH) E14 guideline in 2005, regulators have required a “thorough QTc” (TQT) study for evaluating the effects of investigational drugs on delayed cardiac repolarization as manifested by a prolonged QTc interval. However, TQT studies have increasingly been viewed unfavorably because of their low cost effectiveness. Several researchers have noted that a robust drug concentration‐QTc (conc‐QTc) modeling assessment in early phase development should, in most cases, obviate the need for a subsequent TQT study. In December 2015, ICH released an “E14 Q&As (R3)” document supporting the use of conc‐QTc modeling for regulatory decisions. In this article, we propose a simple improvement of two popular conc‐QTc assessment methods for typical first‐in‐human crossover‐like single ascending dose clinical pharmacology trials. The improvement is achieved, in part, by leveraging routinely encountered (and expected) intrasubject correlation patterns encountered in such trials. A real example involving a single ascending dose and corresponding TQT trial, along with results from a simulation study, illustrate the strong performance of the proposed method. The improved conc‐QTc assessment will further enable highly reliable go/no‐go decisions in early phase clinical development and deliver results that support subsequent TQT study waivers by regulators. 相似文献
72.
法律的概括性、抽象性、发展性等特点决定了有必要强调办案的社会效果。强调办案的社会效果有利于制约司法自由裁量权,是新时期司法工作的必然要求。 相似文献
73.
Using a sample of 42,329 respondents nested within 4254 Canadian urban neighborhoods, this study demonstrates the conceptual and empirical importance of making a distinction between neighborhood racial diversity and minority concentration, and examines how each is uniquely associated with trust. Our analysis shows that at a given level of racial minority concentration, Whites are more trusting when their minority neighbors are more evenly distributed across racial minority groups. Meanwhile, Whites are less trusting as the neighborhood share of racial minorities increases. Overall, the effect of racial minority concentration tends to prevail over that of racial diversity. 相似文献
74.
Peter Hall Tapabrata Maiti 《Journal of the Royal Statistical Society. Series B, Statistical methodology》2009,71(3):703-718
Summary. We develop a general non-parametric approach to the analysis of clustered data via random effects. Assuming only that the link function is known, the regression functions and the distributions of both cluster means and observation errors are treated non-parametrically. Our argument proceeds by viewing the observation error at the cluster mean level as though it were a measurement error in an errors-in-variables problem, and using a deconvolution argument to access the distribution of the cluster mean. A Fourier deconvolution approach could be used if the distribution of the error-in-variables were known. In practice it is unknown, of course, but it can be estimated from repeated measurements, and in this way deconvolution can be achieved in an approximate sense. This argument might be interpreted as implying that large numbers of replicates are necessary for each cluster mean distribution, but that is not so; we avoid this requirement by incorporating statistical smoothing over values of nearby explanatory variables. Empirical rules are developed for the choice of smoothing parameter. Numerical simulations, and an application to real data, demonstrate small sample performance for this package of methodology. We also develop theory establishing statistical consistency. 相似文献
75.
Substance‐dependent women becoming mothers: breaking the cycle of adverse childhood experiences
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Eli Marie Wiig Bente Storm Mowatt Haugland Astrid Halsa Siv Merethe Myhra 《Child & Family Social Work》2017,22(1):26-35
Parenting may be particularly challenging for substance‐dependent mothers who have grown up with parents who themselves had substance use disorders (SUDs). The aim of this study was to explore how substance‐dependent mothers describe their childhood experiences with substance‐abusing parents and the association between these earlier experiences and their own role as caregivers. Using purposeful sampling, mothers admitted for 1 year to a family ward at a substance abuse clinic were approached. Through in‐depth, qualitative interviews, nine substance‐dependent mothers described their lives in the form of present, past and future tense. The findings indicate that substance‐dependent women, who have experienced SUDs in their families of origin, face several major challenges when they become mothers. Some describe having lived their whole lives ‘on the edge of society'. This makes their rehabilitation process more complex. All mothers work to abstain from substances, process traumatic experiences and integrate their family into society. They need help to build supportive social networks and to establish a safe and predictable family environment for themselves and their children. The therapeutic implications of these findings will be discussed. 相似文献
76.
Ning Hao 《The American statistician》2017,71(4):291-297
The problem of interaction selection in high-dimensional data analysis has recently received much attention. This note aims to address and clarify several fundamental issues in interaction selection for linear regression models, especially when the input dimension p is much larger than the sample size n. We first discuss how to give a formal definition of “importance” for main and interaction effects. Then we focus on two-stage methods, which are computationally attractive for high-dimensional data analysis but thus far have been regarded as heuristic. We revisit the counterexample of Turlach and provide new insight to justify two-stage methods from the theoretical perspective. In the end, we suggest new strategies for interaction selection under the marginality principle and provide some simulation results. 相似文献
77.
Kung-Jong Lui 《统计学通讯:模拟与计算》2017,46(7):5229-5239
We consider hypothesis testing and estimation of carry-over effects in continuous data under an incomplete block crossover design when comparing two experimental treatments with a placebo. We develop procedures for testing differential carry-over effects based on the weighted-least-squares (WLS) method. We apply Monte Carlo simulations to evaluate the performance of these test procedures in a variety of situations. We use the data regarding the forced expiratory volume in one second (FEV1) readings taken from a double-blind crossover trial comparing two different doses of formoterol with a placebo to illustrate the use of test procedures proposed here. 相似文献
78.
The multiple non symmetric correspondence analysis (MNSCA) is a useful technique for analyzing a two-way contingency table. In more complex cases, the predictor variables are more than one. In this paper, the MNSCA, along with the decomposition of the Gray–Williams Tau index, in main effects and interaction term, is used to analyze a contingency table with two predictor categorical variables and an ordinal response variable. The Multiple-Tau index is a measure of association that contains both main effects and interaction term. The main effects represent the change in the response variables due to the change in the level/categories of the predictor variables, considering the effects of their addition, while the interaction effect represents the combined effect of predictor categorical variables on the ordinal response variable. Moreover, for ordinal scale variables, we propose a further decomposition in order to check the existence of power components by using Emerson's orthogonal polynomials. 相似文献
79.
80.
The effects which interviewers exert on the collection of ego-centric networks have recently come into the focus of methodological considerations. Studies consistently show that the size of networks varies depending on the interviewer. We would like to expand on this research strand by pointing to different aspects which have so far gone unremarked in the discussion. First, size is mainly analysed as a network measure which is influenced during data collection, while other common measures such as network density or composition have not received sufficient consideration. Second, large-scale surveys using face-to-face interviews usually allocate interviewers to a single sampling point. Differences between sampling points (locality effects) are attributed to interviewer effects. Hence, we disentangle the effects of the locality and interviewer. Third, the discussion on interviewer effects often follows an “actor-oriented” consideration of how data collection situations are structured by interviewers. Expanding this approach from a relational perspective, we consider the relationship between the interviewers and respondents and whether this relationship influences the collection of network data. To test our hypotheses about the influence of interviewers, the locality and the interviewer-respondent relationship on different network measures, we use data from the 2010 German General Social Survey (n = 2827 respondents, n = 220 interviewers). The multilevel analyses show that the relationship between the interviewer and the respondent is not very relevant. Furthermore, the analyses show that interviewers have an influence on the network size but not on measures of their composition. However, evidence on the prevalence of locality or interviewer effects is mixed. Finally, homophilous interviewer-respondent relationships have very little effect on network characteristics. We find evidence of training and fatigue effects on network size. However, much of the variation in network size caused by the interviewer still remains unexplained. We draw conclusions on how to organize interview situations in surveys. 相似文献