Feature significance in generalized additive models

This paper develops inference for the significance of features such as peaks and valleys observed in additive modeling through an extension of the SiZer-type methodology of Chaudhuri and Marron (1999) and Godtliebsen et al. (2002, 2004) to the case where the outcome is discrete. We consider the problem of determining the significance of features such as peaks or valleys in observed covariate effects both for the case of additive modeling where the main predictor of interest is univariate as well as the problem of studying the significance of features such as peaks, inclines, ridges and valleys when the main predictor of interest is geographical location. We work with low rank radial spline smoothers to allow to the handling of sparse designs and large sample sizes. Reducing the problem to a Generalised Linear Mixed Model (GLMM) framework enables derivation of simulation-based critical value approximations and guards against the problem of multiple inferences over a range of predictor values. Such a reduction also allows for easy adjustment for confounders including those which have an unknown or complex effect on the outcome. A simulation study indicates that our method has satisfactory power. Finally, we illustrate our methodology on several data sets.     

中国宏观经济预警体系的评价与修正

摘　　要:中国宏观经济预警体系建立于20世纪90年代初,十多年来为国家宏观调控提供了可靠的信息,成为宏观调控的主要依据之一。然而,进入本世纪以来,中国经济的运行格局发生了重大变化,导致预警体系的敏感度和预测精度出现了偏差,已经到了需要修正的时候。本文在对中国宏观预警体系分析与评价的基础上,对体系的结构与指标提出了修正的思路与方案。     

我国商业银行无形资产统计问题研究

摘　　要:商业银行无形资产是形成商业银行核心竞争力的基础和产生超额收益的源泉,加强商业银行无形资产统计工作,有利于充分揭示商业银行无形资产基本内容和对核心竞争力的影响。笔者认为,目前我国商业银行无形资产统计指标体系设置不完整,统计制度不健全,统计内容不全面,统计分析不深入,影响经济决策。笔者认为,完善商业银行无形资产统计制度时,应从组织结构类、客户关系类、知识创新类和人力资本类等四个方面对无形资产进行统计,逐步细化统计指标,明确具体的统计内容,建立、健全无形资产价值信息系统,深化无形资产统计分析工作,以此为基础,提出提高商业银行核心竞争力的基本策略。     

股份制改革是增强国营企业活力创造“深圳效益”的重要途径

本文分析了深圳特区前10年经济高速发展和经济效益滞后的矛盾,认为特区国营企业经济效益不高是影响特区经济效益严重滞后的主要原因之一。在此基础上,提出深圳特区要在90年代创造出“深圳效益”,必须在已取得的改革成果的基础上,加快国营企业股份制改革的进程。文章还从股份制改革的理论和实践两个方面阐述了特区国营企业股份制改革的可行性和必要性。     

论我国高等教育运行机制的过渡与转换

本文认为,我国现阶段的高教运行机制正处于过渡与转换的初始阶段,机制转换的完成需要经历一个较长的过渡时期.为了顺利平稳地完成机制转换,必须构建相应的过渡性目标模式,以此作为从适应产品经济到适应有计划的商品经济的高教运行机制模式转换的中介。因此,今后—个时期高教改革的基本思路就不应只朝一个方向努力,而应以国家职能转变为契机,在国家、社会和学校三方面同时展开,并辅之于教育市场的不断培育和竞争机制的逐步加强。     

项目风险分析与管理

本文在分析比较传统风险分析方法的基础上,提出了一个更为有效的风险分析方法,即“交叉分析-蒙特卡罗模拟”综合模型。并利用此模型对H集团的某技改投资项目进行了案例分析。在此基础上,提出了建立项目风险防范预警系统的风险管理模式。     

Constructing optimal designs for fitting pharmacokinetic models

We consider some computational issues that arise when searching for optimal designs for pharmacokinetic (PK) studies. Special factors that distinguish these are (i) repeated observations are taken from each subject and the observations are usually described by a nonlinear mixed model (NLMM), (ii) design criteria depend on the model fitting procedure, (iii) in addition to providing efficient parameter estimates, the design must also permit model checking, (iv) in practice there are several design constraints, (v) the design criteria are computationally expensive to evaluate and often numerical integration is needed and finally (vi) local optimisation procedures may fail to converge or get trapped at local optima.We review current optimal design algorithms and explore the possibility of using global optimisation procedures. We use these latter procedures to find some optimal designs.For multi-purpose designs we suggest two surrogate design criteria for model checking and illustrate their use.     

The Effect of Drop-Out on the Efficiency of Longitudinal Experiments

It is shown that drop-out often reduces the efficiency of longitudinal experiments considerably. In the framework of linear mixed models, a general, computationally simple method is provided, for designing longitudinal studies when drop-out is to be expected, such that there is little risk of large losses of efficiency due to the missing data. All the results are extensively illustrated using data from a randomized experiment with rats.     

A methodological strategy for a one-number census in the UK

As a result of lessons learnt from the 1991 census, a research programme was set up to seek improvements in census methodology. Underenumeration has been placed top of the agenda in this programme, and every effort is being made to achieve as high a coverage as possible in the 2001 census. In recognition, however, that 100% coverage will never be achieved, the one-number census (ONC) project was established to measure the degree of underenumeration in the 2001 census and, if possible, to adjust fully the outputs from the census for that undercount. A key component of this adjustment process is a census coverage survey (CCS). This paper presents an overview of the ONC project, focusing on the design and analysis methodology for the CCS. It also presents results that allow the reader to evaluate the robustness of this methodology.     

基于未确知测度方法的城市化水平评价研究

城市化水平是一个国家和地区经济、社会、文化、科技水平的重要标志,也是衡量国家和地区社会组织程度和管理水平的重要标志。实施城市化战略,推进城市化进程,是我国逐步摆脱不发达状态,实现现代化历史任务的目标和手段的统一,也是21世纪初我国现代化建设中的重要任务。因此,做好城市化水平的评价工作对于一个地区的发展有着重要的战略意义。论文研究了信息熵和未确知测度方法在城市化水平评价中的应用,给出了综合评价模型,并结合实例进行验证分析。