Two sets of isotones for comparing tests of exponentiality

Isotones   are a deterministic graphical device introduced by Mudholkar et al. [1991. A graphical procedure for comparing goodness-of-fit tests. J. Roy. Statist. Soc. B 53, 221–232], in the context of comparing some tests of normality. An isotone of a test is a contour of p values of the test applied to “ideal samples”, called profiles, from a two-shape-parameter family representing the null and the alternative distributions of the parameter space. The isotone is an adaptation of Tukey's sensitivity curves, a generalization of Prescott's stylized sensitivity contours, and an alternative to the isodynes   of Stephens. The purpose of this paper is two fold. One is to show that the isotones can provide useful qualitative information regarding the behavior of the tests of distributional assumptions other than normality. The other is to show that the qualitative conclusions remain the same from one two-parameter family of alternatives to another. Towards this end we construct and interpret the isotones of some tests of the composite hypothesis of exponentiality, using the profiles of two Weibull extensions, the generalized Weibull and the exponentiated Weibull families, which allow IFR, DFR, as well as unimodal and bathtub failure rate alternatives. Thus, as a by-product of the study, it is seen that a test due to Csörg? et al. [1975. Application of characterizations in the area of goodness-of-fit. In: Patil, G.P., Kotz, S., Ord, J.K. (Eds.), Statistical Distributions in Scientific Work, vol. 2. Reidel, Boston, pp. 79–90], and Gnedenko's Q(r) test [1969. Mathematical Methods of Reliability Theory. Academic Press, New York], are appropriate for detecting monotone failure rate alternatives, whereas a bivariate F test due to Lin and Mudholkar [1980. A test of exponentiality based on the bivariate F distribution. Technometrics 22, 79–82] and their entropy test [1984. On two applications of characterization theorems to goodness-of-fit. Colloq. Math. Soc. Janos Bolyai 45, 395–414] can detect all alternatives, but are especially suitable for nonmonotone failure rate alternatives.     

沪深300指数期货与现货市场的动态关联性研究——基于2010年4月16日以来的高频数据

自从沪深300指数期货自2010年4月16日正式上市以来,其与现货市场的动态联系引起了监管层和投资者的广泛关注。论文使用双变量VECM-BEKK-GARCH模型,基于5分钟日内数据研究了沪深300期货价格与现货价格之间的引导关系,以及两市场间的波动溢出情况,发现无论长期还是短期价格发现能力,沪深300期货价格上都要领先现货价格,而且沪深300指数期货与沪深300现货市场之间存在双向的波动溢出效应。并从市场微观结构的角度,揭示了期货、现货市场信息效率差异的原因。     

Accelerated life test planning with independent lognormal competing risks

In accelerated life testing (ALT), products are exposed to stress levels higher than those at normal use in order to obtain information in a timely manner. Past work on planning ALT is predominantly on a single cause of failure. This article presents methods for planning ALT in the presence of k competing risks. Expressions for computing the Fisher information matrix are presented when risks are independently distributed lognormal. Optimal test plans are obtained under criteria that are based on determinants and maximum likelihood estimation. The proposed method is demonstrated on ALT of motor insulation.     

DT-optimum designs for model discrimination and parameter estimation

The paper introduces DT-optimum designs that provide a specified balance between model discrimination and parameter estimation. An equivalence theorem is presented for the case of two models and extended to an arbitrary number of models and of combinations of parameters. A numerical example shows the properties of the procedure. The relationship with other design procedures for parameter estimation and model discrimination is discussed.     

New 3-level response surface designs constructed from incomplete block designs

Box and Behnken [1958. Some new three level second-order designs for surface fitting. Statistical Technical Research Group Technical Report No. 26. Princeton University, Princeton, NJ; 1960. Some new three level designs for the study of quantitative variables. Technometrics 2, 455–475.] introduced a class of 3-level second-order designs for fitting the second-order response surface model. These 17 Box–Behnken designs (BB designs) are available for 3–12 and 16 factors. Although BB designs were developed nearly 50 years ago, they and the central-composite designs of Box and Wilson [1951. On the experimental attainment of optimum conditions. J. Royal Statist. Soc., Ser. B 13, 1–45.] are still the most often recommended response surface designs. Of the 17 aforementioned BB designs, 10 were constructed from balanced incomplete block designs (BIBDs) and seven were constructed from partially BIBDs (PBIBDs). In this paper we show that these seven BB designs constructed from PBIBDs can be improved in terms of rotatability as well as average prediction variance, D- and G-efficiency. In addition, we also report new orthogonally blocked solutions for 5, 8, 9, 11 and 13 factors. Note that an 11-factor BB design is available but cannot be orthogonally blocked. All new designs can be found at http://www.math.montana.edu/∼jobo/bbd/.     

Empirical Bayes vs. fully Bayes variable selection

For the problem of variable selection for the normal linear model, fixed penalty selection criteria such as AIC, _Cp, BIC and RIC correspond to the posterior modes of a hierarchical Bayes model for various fixed hyperparameter settings. Adaptive selection criteria obtained by empirical Bayes estimation of the hyperparameters have been shown by George and Foster [2000. Calibration and Empirical Bayes variable selection. Biometrika 87(4), 731–747] to improve on these fixed selection criteria. In this paper, we study the potential of alternative fully Bayes methods, which instead margin out the hyperparameters with respect to prior distributions. Several structured prior formulations are considered for which fully Bayes selection and estimation methods are obtained. Analytical and simulation comparisons with empirical Bayes counterparts are studied.     

Cost-cautious designs for confirmatory bioassay

Confirmatory bioassay experiments take place in late stages of the drug discovery process when a small number of compounds have to be compared with respect to their properties. As the cost of the observations may differ considerably, the design problem is well specified by the cost of compound used rather than by the number of observations. We show that cost-efficient designs can be constructed using useful properties of the minimum support designs. These designs are particularly suited for studies where the parameters of the model to be estimated are known with high accuracy prior to the experiment, although they prove to be robust against typical inaccuracies of these values. When the parameters of the model can only be specified with ranges of values or by a probability distribution, we use a Bayesian criterion of optimality to construct the required designs. Typically, the number of their support points depends on the prior knowledge for the model parameters. In all cases we recommend identifying a set of designs with good statistical properties but different potential costs to choose from.     

Pilot–pivotal trials for average bioequivalence

Before carrying out a full scale bioequivalence trial, it is desirable to conduct a pilot trial to decide if a generic drug product shows promise of bioequivalence. The purpose of a pilot trial is to screen test formulations, and hence small sample sizes can be used. Based on the outcome of the pilot trial, one can decide whether or not a full scale pivotal trial should be carried out to assess bioequivalence. This article deals with the design of a pivotal trial, based on the evidence from the pilot trial. A two-stage adaptive procedure is developed in order to determine the sample size and the decision rule for the pivotal trial, for testing average bioequivalence using the two one-sided test (TOST). Numerical implementation of the procedure is discussed in detail, and the required tables are provided. Numerical results indicate that the required sample sizes could be smaller than that recommended by the FDA for a single trial, especially when the pilot study provides strong evidence in favor of bioequivalence.     

Negative dependence and the Simes inequality

It is shown that the Simes inequality is reversed for a broad class of negatively dependent distributions.