Nonparametric and semiparametric estimation of the three way receiver operating characteristic surface

In many situations the diagnostic decision is not limited to a binary choice. Binary statistical tools such as receiver operating characteristic (ROC) curve and area under the ROC curve (AUC) need to be expanded to address three-category classification problem. Previous authors have suggest various ways to model the extension of AUC but not the ROC surface. Only simple parametric approaches are proposed for modeling the ROC measure under the assumption that test results all follow normal distributions. We study the estimation methods of three-dimensional ROC surfaces with nonparametric and semiparametric estimators. Asymptotical results are provided as a basis for statistical inference. Simulation studies are performed to assess the validity of our proposed methods in finite samples. We consider an Alzheimer's disease example from a clinical study in the US as an illustration. The nonparametric and semiparametric modelling approaches for the three way ROC analysis can be readily generalized to diagnostic problems with more than three classes.     

On pseudo-values for regression analysis in competing risks models

For regression on state and transition probabilities in multi-state models Andersen et al. (Biometrika 90:15–27, 2003) propose a technique based on jackknife pseudo-values. In this article we analyze the pseudo-values suggested for competing risks models and prove some conjectures regarding their asymptotics (Klein and Andersen, Biometrics 61:223–229, 2005). The key is a second order von Mises expansion of the Aalen-Johansen estimator which yields an appropriate representation of the pseudo-values. The method is illustrated with data from a clinical study on total joint replacement. In the application we consider for comparison the estimates obtained with the Fine and Gray approach (J Am Stat Assoc 94:496–509, 1999) and also time-dependent solutions of pseudo-value regression equations.     

Saddlepoint-Based Bootstrap Inference for Quadratic Estimating Equations

Abstract.  We propose an easy to implement method for making small sample parametric inference about the root of an estimating equation expressible as a quadratic form in normal random variables. It is based on saddlepoint approximations to the distribution of the estimating equation whose unique root is a parameter's maximum likelihood estimator (MLE), while substituting conditional MLEs for the remaining (nuisance) parameters. Monotoncity of the estimating equation in its parameter argument enables us to relate these approximations to those for the estimator of interest. The proposed method is equivalent to a parametric bootstrap percentile approach where Monte Carlo simulation is replaced by saddlepoint approximation. It finds applications in many areas of statistics including, nonlinear regression, time series analysis, inference on ratios of regression parameters in linear models and calibration. We demonstrate the method in the context of some classical examples from nonlinear regression models and ratios of regression parameter problems. Simulation results for these show that the proposed method, apart from being generally easier to implement, yields confidence intervals with lengths and coverage probabilities that compare favourably with those obtained from several competing methods proposed in the literature over the past half-century.     

人口普查覆盖误差估计方法综述

人口普查工作的质量主要体现在覆盖误差的规模上.人口统计学家创建了估计人口普查覆盖误差的方法.有些方法利用独立于人口普查本身的信息,另外一些方法则利用人口行政记录的信息.由于每种方法都有其特定的形成背景和适用范围,因而没有适合于所有国家和地区的通用方法.通过对美国、新西兰、澳大利亚、英国和中国的人口普查覆盖误差估计方法进行了较为详细的介绍,说明了这些方法的使用情况.研究表明,任何一种估计方法都有其局限性,需要不断改进与完善.     

健康在多大程度上引致贫困脆弱性——基于CHNS农村数据的经验分析

贫困脆弱性的产生,很大程度上归因于居民健康水平的下降.在阐述健康引致贫困理论机制的基础上,基于CHNS在2000-2009年间追踪调查数据,对贫困脆弱性和健康效用指数HUI进行测度,估计并分析健康对贫困脆弱性的影响与内在机制.研究发现:居民健康水平的恶化会使其面临更高的贫困脆弱性,居民健康水平每下降10％,贫困脆弱性大约会上升6％;健康影响贫困脆弱性的作用机制中,物质资本和社会资本渠道被证明是相对有效的,而人力资本渠道尽管体现出微弱效应,但尚未在统计上得到显著性验证.因此,制订前瞻性的反贫政策应着眼于建立健康风险防范机制,包括提高农村医疗保障水平和重大疾病救助力度,并增加农村公共服务的投入,以促进其均衡化发展.     

Bayesian influence diagnostics in radiocarbon dating

Linear models constitute the primary statistical technique for any experimental science. A major topic in this area is the detection of influential subsets of data, that is, of observations that are influential in terms of their effect on the estimation of parameters in linear regression or of the total population parameters. Numerous studies exist on radiocarbon dating which propose a value consensus and remove possible outliers after the corresponding testing. An influence analysis for the value consensus from a Bayesian perspective is developed in this article.     

A joint modelling approach for clustered recurrent events and death events

In dental implant research studies, events such as implant complications including pain or infection may be observed recurrently before failure events, i.e. the death of implants. It is natural to assume that recurrent events and failure events are correlated to each other, since they happen on the same implant (subject) and complication times have strong effects on the implant survival time. On the other hand, each patient may have more than one implant. Therefore these recurrent events or failure events are clustered since implant complication times or failure times within the same patient (cluster) are likely to be correlated. The overall implant survival times and recurrent complication times are both interesting to us. In this paper, a joint modelling approach is proposed for modelling complication events and dental implant survival times simultaneously. The proposed method uses a frailty process to model the correlation within cluster and the correlation within subjects. We use Bayesian methods to obtain estimates of the parameters. Performance of the joint models are shown via simulation studies and data analysis.     

Decomposing the predictive performance of the moving average trading rule of technical analysis: the contribution of linear and non-linear dependencies in stock returns

The main purpose of this work is to decompose the predictive performance of the moving average (MA) trading rule and find out the portion that could be attributed to the possible exploitation of linear and non-linear dependencies in stock returns. Data from the General Index of the Athens Stock Exchange, from the Standard and Poor-500 Index of the New York Stock Exchange and from the Austrian Traded Index of the Vienna Stock Exchange are filtered by linear filters so as the resulting simulated ‘returns’ exhibit no serial correlation. Applying MA trading rules to both the original and the simulated indices and using a new statistical testing procedure that takes into account the sensitivity of the performance of the trading rule as a function of the length of the MA it is found that the predictive performance of the trading rule is clearly weakened when applied to the simulated indices indicating that a substantial part of the rule's predictive performance is due to the exploitation of linear dependencies in stock returns. This weakening is uneven; in general the shorter the MA length the more pronounced the attenuation.     

Generalized estimating equations for mixtures with varying concentrations

A finite mixture model is considered in which the mixing probabilities vary from observation to observation. A parametric model is assumed for one mixture component distribution, while the others are nonparametric nuisance parameters. Generalized estimating equations (GEE) are proposed for the semi‐parametric estimation. Asymptotic normality of the GEE estimates is demonstrated and the lower bound for their dispersion (asymptotic covariance) matrix is derived. An adaptive technique is developed to derive estimates with nearly optimal small dispersion. An application to the sociological analysis of voting results is discussed. The Canadian Journal of Statistics 41: 217–236; 2013 © 2013 Statistical Society of Canada