Fe—C相图的形成

本文以纯Fe相图为基础,探讨了Fe—C相图的形成过程。重点论述了Fe—Fe_3C相图形成的规律性,并对其形成规律性进行了讨论与分析,从而为进一步理解、应用Fe—Fe_3C相图奠定了基础。     

高功率微波振荡器功率合成中的锁频与锁相

全面分析和评述了高功率微波振荡器功率合成中的锁频与锁相。研究腔振荡器的主从锁相，互耦根荡器的等同锁相以及环形串接互耦振荡器、中心联结网状互耦振荡器的等同锁相等不同锁相方式的基本原理与方法，并给出数值计算结果；讨论相位与锁相方式和根荡器有关参量的关系；简要介绍高功率微波的腔体功率合成与空间功率合成的概念。     

一种锁相环调频信号解调集成电路的设计

介绍了一种调频信号解调实用集成电路芯片ＵＥ７０１的设计与开发。此芯片为正向设计的模拟集成电路，采用锁相环对调频信号实现解调，因而信噪比高，且易于集成。在国内现有工艺条件下，做出了满足低电压、低功耗和抗干扰能力强的产品。该产品可广泛用作各种电子系统的调频信号处理部件。     

改进的修正哈达玛方差的偏差研究

利用文献[1]的理论,对改进的修正哈达玛方差(IMHV)法估计频率源的相位噪声功率谱的偏差问题作了全面的研究。     

转型经济下我国创业制度环境变迁的实证研究

本文基于中国转型经济背景,在对转型阶段进行划分的基础上,通过对全国十几个省市调研样本的实证分析,探究了两个转型阶段的创业制度环境在规制性、规范性和认知性等几个方面的变化规律和程度。结论表明,在转型的第三阶段,制度环境的各维度均优于转型第二阶段,但各维度的改善程度存在差异。最后,本文给出了研究启示。     

20世纪儒家文艺思想研究概述

儒家文艺思想作为儒家思想体系的一个重要组成部分,它在20世纪中国的命运正如儒家思想的开创者孔子的命运一样,在不断被阐释的过程中显示出其独有的魅力,但被误解、被扭曲,甚至被彻底否定或尊为至高无上的情形也多有出现。它对20世纪中国文艺学体系的建构也起着重要的作用。20世纪对儒家文艺思想的研究实际上是对研究对象的阐释与创造的过程。儒家文艺思想的研究分三个阶段,每一阶段由于受时代的政治、经济、文化等的影响其研究的具体对象与结论都表现出各自不同的特点。     

Compound designs for dose‐finding in the presence of nondesignable covariates

Compound optimal designs are considered where one component of the design criterion is a traditional optimality criterion such as the D‐optimality criterion, and the other component accounts for higher efficacy with low toxicity. With reference to the dose‐finding problem, we suggest the technique to choose weights for the two components that makes the optimization problem simpler than the traditional penalized design. We allow general bivariate responses for efficacy and toxicity. We then extend the procedure in the presence of nondesignable covariates such as age, sex, or other health conditions. A new breast cancer treatment is considered to illustrate the procedures. Copyright © 2013 John Wiley & Sons, Ltd.     

An adaptive model switching approach for phase I dose‐finding trials

Model‐based phase I dose‐finding designs rely on a single model throughout the study for estimating the maximum tolerated dose (MTD). Thus, one major concern is about the choice of the most suitable model to be used. This is important because the dose allocation process and the MTD estimation depend on whether or not the model is reliable, or whether or not it gives a better fit to toxicity data. The aim of our work was to propose a method that would remove the need for a model choice prior to the trial onset and then allow it sequentially at each patient's inclusion. In this paper, we described model checking approach based on the posterior predictive check and model comparison approach based on the deviance information criterion, in order to identify a more reliable or better model during the course of a trial and to support clinical decision making. Further, we presented two model switching designs for a phase I cancer trial that were based on the aforementioned approaches, and performed a comparison between designs with or without model switching, through a simulation study. The results showed that the proposed designs had the advantage of decreasing certain risks, such as those of poor dose allocation and failure to find the MTD, which could occur if the model is misspecified. Copyright © 2013 John Wiley & Sons, Ltd.     

Dose finding when the target dose is on a plateau of a dose–response curve: comparison of fully sequential designs

Consider the problem of estimating a dose with a certain response rate. Many multistage dose‐finding designs for this problem were originally developed for oncology studies where the mean dose–response is strictly increasing in dose. In non‐oncology phase II dose‐finding studies, the dose–response curve often plateaus in the range of interest, and there are several doses with the mean response equal to the target. In this case, it is usually of interest to find the lowest of these doses because higher doses might have higher adverse event rates. It is often desirable to compare the response rate at the estimated target dose with a placebo and/or active control. We investigate which of the several known dose‐finding methods developed for oncology phase I trials is the most suitable when the dose–response curve plateaus. Some of the designs tend to spread the allocation among the doses on the plateau. Others, such as the continual reassessment method and the t‐statistic design, concentrate allocation at one of the doses with the t‐statistic design selecting the lowest dose on the plateau more frequently. Copyright © 2013 John Wiley & Sons, Ltd.     

中美比较思想政治教育的形成与发展

中美比较思想政治教育是一门年轻的学科,始于20世纪80年代中期。经过20多年的发展,逐步形成了学科体系。从1986年至今,中美比较思想政治教育的形成与发展大致可以分为三个阶段：1986年到1995年时期以区域性研究起步的奠基阶段,1996年到2005年时期以＂借鉴＂为特征的拓展阶段,2006年至今以＂分析＂为特征的深化阶段。以区域研究起步,对美国思想政治教育现象进行介绍和借鉴,进而深入的比较和分析现象背后的原因和力量,试图以此找到思想政治教育的共性、特殊性,有效实现美国经验的＂本土化＂。