Armitage-Doll Two-Stage Model: Implications and Extension

The objective of this paper is twofold: (1) to provide insight on the simplified MVK model of carcinogenesis (a model proposed by Moolgavkar and colleagues) by revealing the relationship between the Armitage-Doll two-stage model and the simplified MVK model; and (2) to extend the Armitage-Doll two-stage model to one with time-varying (piece-wise constant) parameters. It is shown that the simplified MVK model is a special case of the Armitage-Doll two-stage model, and many applications of the simplified MVK model involving intermittent exposures or exposures to different compounds in different time periods can be derived easily from the Armitage-Doll two-stage model with piece-wise constant parameters. The limitations of the Armitage-Doll two-stage model are discussed.     

Irregular Identification,Support Conditions,and Inverse Weight Estimation

In weighted moment condition models, we show a subtle link between identification and estimability that limits the practical usefulness of estimators based on these models. In particular, if it is necessary for (point) identification that the weights take arbitrarily large values, then the parameter of interest, though point identified, cannot be estimated at the regular (parametric) rate and is said to be irregularly identified. This rate depends on relative tail conditions and can be as slow in some examples as n^−1/4. This nonstandard rate of convergence can lead to numerical instability and/or large standard errors. We examine two weighted model examples: (i) the binary response model under mean restriction introduced by Lewbel (1997) and further generalized to cover endogeneity and selection, where the estimator in this class of models is weighted by the density of a special regressor, and (ii) the treatment effect model under exogenous selection (Rosenbaum and Rubin (1983)), where the resulting estimator of the average treatment effect is one that is weighted by a variant of the propensity score. Without strong relative support conditions, these models, similar to well known “identified at infinity” models, lead to estimators that converge at slower than parametric rate, since essentially, to ensure point identification, one requires some variables to take values on sets with arbitrarily small probabilities, or thin sets. For the two models above, we derive some rates of convergence and propose that one conducts inference using rate adaptive procedures that are analogous to Andrews and Schafgans (1998) for the sample selection model.     

北京高校甲组田径优势运动项目分析

通过对北京市入选综合排名前8名学校的优势项目进行统计分析,可以得出以下结论:第一集团学校的优势项目群配置合理,综合排名前四名学校的优势项目群呈现不同程度的重叠现象;各高校优势项目群的消长率增长与降低总体呈交替性波动,整体呈两级分化趋势;速度项目群将会领先于其他项群而得到优先发展.     

欧美企业克服传统预算管理缺陷的最新实践

由于传统预算管理存在缺乏灵活性、缺乏效率等缺陷,欧美企业采取了一系列的改进措施,如广泛运用信息一体化技术、注重预算与战略的结合、运用一体化的预测模型等方法和手段提高预算的灵活性和效率,取得了良好的效果.     

Generalized Linear Failure Rate Distribution

The exponential and Rayleigh are the two most commonly used distributions for analyzing lifetime data. These distributions have several desirable properties and nice physical interpretations. Unfortunately, the exponential distribution only has constant failure rate and the Rayleigh distribution has increasing failure rate. The linear failure rate distribution generalizes both these distributions which may have non increasing hazard function also. This article introduces a new distribution, which generalizes linear failure rate distribution. This distribution generalizes the well-known (1) exponential distribution, (2) linear failure rate distribution, (3) generalized exponential distribution, and (4) generalized Rayleigh distribution. The properties of this distribution are discussed in this article. The maximum likelihood estimates of the unknown parameters are obtained. A real data set is analyzed and it is observed that the present distribution can provide a better fit than some other very well-known distributions.     

Classification of Observations into One of Two Artificially Dichotomized Classes by Using a Normal Screening Variable

This article considers a problem of normal based two group classification when the groups are artificially dichotomized by a screening variable. Each group distribution is derived and the best regions for the classification are obtained. These derivations yield yet another classification rule. The rule is studied from several aspects such as the distribution of the rule, the optimal error rate, and the testing of a hypothesis. This article gives relationships among these aspects along with the investigation of the performance of the rule. The classification method and ideas are illustrated in detail with two examples.     

The Ruin Probability of a Discrete-Time Risk Model with a One-Sided Linear Claim Process

In this article, the ruin probability is examined in a discrete time risk model with a constant interest rate, in which the dependent claims are assumed to have a one-sided linear structure. An explicit asymptotic formula is obtained for the ruin probability. Generalized Lundberg inequalities for the ruin probability are derived by martingale and inductive approaches.     

The Dynamic Model for Cancer Relapse Based on Two-Stage Model of Carcinogenesis

In this article, the time from the start of chemotherapy randomization until cancer relapse is of primary interest. Here, cancer relapse refers to the appearance of the first observable malignant clone after therapy. A dynamic model for cancer relapse after chemotherapy is developed. The model differs from the traditional cure rate models in that it takes into consideration the growth kinetics of malignant tumors using a two-stage carcinogenesis model. The survival and hazard functions for cancer relapse time are derived, and a simulation study is performed to validate the underlying model.     

The Poisson Generalized Linear Failure Rate Model

We formulate a new cure rate survival model by assuming that the number of competing causes of the event of interest has the Poisson distribution, and the time to this event has the generalized linear failure rate distribution. A new distribution to analyze lifetime data is defined from the proposed cure rate model, and its quantile function as well as a general expansion for the moments is derived. We estimate the parameters of the model with cure rate in the presence of covariates for censored observations using maximum likelihood and derive the observed information matrix. We obtain the appropriate matrices for assessing local influence on the parameter estimates under different perturbation schemes and present some ways to perform global influence analysis. The usefulness of the proposed cure rate survival model is illustrated in an application to real data.     

Precise Asymptotics in Complete Moment Convergence of Parameter Estimator in the Gaussian Autoregressive Process

In this article, we study the precise asymptotic behaviors of the least-squares estimator in the Gaussian autoregressive process. Two kinds of complete moment convergence of this estimator can be obtained by the methods of deviation inequalities for this estimator and nonuniform Berry-Esseen bound for martingales.