Detecting change points and monitoring biomedical data

Bayesian and likelihood approaches to on-line detecting change points in time series are discussed and applied to analyze biomedical data. Using a linear dynamic model, the Bayesian analysis outputs the conditional posterior probability of a change at time t ? 1, given the data up to time t and the status of changes occurred before time t ? 1. The likelihood method is based on a change-point regression model and tests whether there is no change-point.     

Forecasting future values of changing sequences

Sequences of independent random variables are observed and on the basis of these observations future values of the process are forecast. The Bayesian predictive density of k future observations for normal, exponential, and binomial sequences which change exactly once are analyzed for several cases. It is seen that the Bayesian predictive densities are mixtures of standard probability distributions. For example, with normal sequences the Bayesian predictive density is a mixture of either normal or t-distributions, depending on whether or not the common variance is known. The mixing probabilities are the same as those occurring in the corresponding posterior distribution of the mean(s) of the sequence. The predictive mass function of the number of future successes that will occur in a changing Bernoulli sequence is computed and point and interval predictors are illustrated.     

Fiducial and Confidence Distributions for Real Exponential Families

We develop an easy and direct way to define and compute the fiducial distribution of a real parameter for both continuous and discrete exponential families. Furthermore, such a distribution satisfies the requirements to be considered a confidence distribution. Many examples are provided for models, which, although very simple, are widely used in applications. A characterization of the families for which the fiducial distribution coincides with a Bayesian posterior is given, and the strict connection with Jeffreys prior is shown. Asymptotic expansions of fiducial distributions are obtained without any further assumptions, and again, the relationship with the objective Bayesian analysis is pointed out. Finally, using the Edgeworth expansions, we compare the coverage of the fiducial intervals with that of other common intervals, proving the good behaviour of the former.     

Bayesian subset selection approach to ranking normal means

In this, article we consider a Bayesian approach to the problem of ranking the means of normal distributed populations, which is a common problem in the biological sciences. We use a decision-theoretic approach with a straightforward loss function to determine a set of candidate rankings. This loss function allows the researcher to balance the risk of not including the correct ranking with the risk of increasing the number of rankings selected. We apply our new procedure to an example regarding the effect of zinc on the diversity of diatom species.     

A bayesian analysis of the mixed linear model

The mixed model is defined. The exact posterior distribution for the fixed effect vector is obtained. The exact posterior distribution for the error variance is obtained. The exact posterior mean and variance of a Bayesian estimator for the variances of random effects is also derived. All computations are non-iterative and avoid numerical integrations.     

Block diagrams and splitting criteria for classification trees

Various aspects of the classification tree methodology of Breiman et al., (1984) are discussed. A method of displaying classification trees, called block diagrams, is developed. Block diagrams give a clear presentation of the classification, and are useful both to point out features of the particular data set under consideration and also to highlight deficiencies in the classification method being used. Various splitting criteria are discussed; the usual Gini-Simpson criterion presents difficulties when there is a relatively large number of classes and improved splitting criteria are obtained. One particular improvement is the introduction of adaptive anti-end-cut factors that take advantage of highly asymmetrical splits where appropriate. They use the number and mix of classes in the current node of the tree to identify whether or not it is likely to be advantageous to create a very small offspring node. A number of data sets are used as examples.     

Likelihood Estimation and Inference in a Class of Nonregular Econometric Models

We study inference in structural models with a jump in the conditional density, where location and size of the jump are described by regression curves. Two prominent examples are auction models, where the bid density jumps from zero to a positive value at the lowest cost, and equilibrium job‐search models, where the wage density jumps from one positive level to another at the reservation wage. General inference in such models remained a long‐standing, unresolved problem, primarily due to nonregularities and computational difficulties caused by discontinuous likelihood functions. This paper develops likelihood‐based estimation and inference methods for these models, focusing on optimal (Bayes) and maximum likelihood procedures. We derive convergence rates and distribution theory, and develop Bayes and Wald inference. We show that Bayes estimators and confidence intervals are attractive both theoretically and computationally, and that Bayes confidence intervals, based on posterior quantiles, provide a valid large sample inference method.     

Bayesian Estimators for Small Area Models Shrinking Both Means and Variances

For small area estimation of area‐level data, the Fay–Herriot model is extensively used as a model‐based method. In the Fay–Herriot model, it is conventionally assumed that the sampling variances are known, whereas estimators of sampling variances are used in practice. Thus, the settings of knowing sampling variances are unrealistic, and several methods are proposed to overcome this problem. In this paper, we assume the situation where the direct estimators of the sampling variances are available as well as the sample means. Using this information, we propose a Bayesian yet objective method producing shrinkage estimation of both means and variances in the Fay–Herriot model. We consider the hierarchical structure for the sampling variances, and we set uniform prior on model parameters to keep objectivity of the proposed model. For validity of the posterior inference, we show under mild conditions that the posterior distribution is proper and has finite variances. We investigate the numerical performance through simulation and empirical studies.     

Bayesian prediction of minimal repair times of a series system based on hybrid censored sample of components’ lifetimes under Rayleigh distribution

In this paper, we develop Bayesian predictive inferential procedures for prediction of repair times of a series system, applying a minimal repair strategy, using the information contained in an independent observed hybrid censored sample of the lifetimes of the components of the system, assuming the underlying distribution of the lifetimes to be Rayleigh distribution. An illustrative real data example and a simulation study are presented for the purpose of illustration and comparison of the proposed predictors.