Continuity of f-projections and applications to the iterative proportional fitting procedure*

This paper proves continuity of f-projections and the continuous dependence of the limit matrix of the iterative proportional fitting procedure (IPF procedure) on the given matrix as well as the given marginals under certain regularity constraints. For finite spaces, the concept of f-projections of finite measures on a compact and convex set is introduced and continuity of f-projections is proven. This result is applied to the IPF procedure. Given a nonnegative matrix as well as row and column marginals the IPF procedure generates a sequence of matrices, called the IPF sequence, by alternately fitting rows and columns to match their respective marginals. The procedure is equivalent to cyclic f-projections. If the IPF sequence converges, the application of the continuity of f-projections yields the continuous dependence of the limit matrix on the given matrix. By generalized convex programming and under some constraints, it is shown that the limit matrix of the IPF sequence continuously depends not only on the given matrix but also on the marginals.     

Variable selection for semiparametric proportional hazards model under progressive Type-II censoring

Variable selection is an effective methodology for dealing with models with numerous covariates. We consider the methods of variable selection for semiparametric Cox proportional hazards model under the progressive Type-II censoring scheme. The Cox proportional hazards model is used to model the influence coefficients of the environmental covariates. By applying Breslow’s “least information” idea, we obtain a profile likelihood function to estimate the coefficients. Lasso-type penalized profile likelihood estimation as well as stepwise variable selection method are explored as means to find the important covariates. Numerical simulations are conducted and Veteran’s Administration Lung Cancer data are exploited to evaluate the performance of the proposed method.     

Regularized proportional odds models

The proportional odds model (POM) is commonly used in regression analysis to predict the outcome for an ordinal response variable. The maximum likelihood estimation (MLE) approach is typically used to obtain the parameter estimates. The likelihood estimates do not exist when the number of parameters, p, is greater than the number of observations n. The MLE also does not exist if there are no overlapping observations in the data. In a situation where the number of parameters is less than the sample size but p is approaching to n, the likelihood estimates may not exist, and if they exist they may have quite large standard errors. An estimation method is proposed to address the last two issues, i.e. complete separation and the case when p approaches n, but not the case when p>n. The proposed method does not use any penalty term but uses pseudo-observations to regularize the observed responses by downgrading their effect so that they become close to the underlying probabilities. The estimates can be computed easily with all commonly used statistical packages supporting the fitting of POMs with weights. Estimates are compared with MLE in a simulation study and an application to the real data.     

A Class of Sampling Two Units with Probability Proportional to Size

A class of sampling two units without replacement with inclusion probability proportional to size is proposed in this article. Many different well known probability proportional to size sampling designs are special cases from this class. The first and second inclusion probabilities of this class satisfy important properties and provide a non-negative variance estimator of the Horvitz and Thompson estimator for the population total. Suitable choice for the first and second inclusion probabilities from this class can be used to reduce the variance estimator of the Horvitz and Thompson estimator. Comparisons between different proportional to size sampling designs through real data and artificial examples are given. Examples show that the minimum variance of the Horvitz and Thompson estimator obtained from the proposed design is not attainable for the most cases at any of the well known designs.     

Counterexamples in unbalanced two-way analysis of variance

Recommended methods for analyzing unbalanced two-way data may be classified into two major categories:the parametric interpretation approach and the model comparison approach. Each approach has its advantages and its drawbacks. The main drawback of the parametric interpretation approach is non-orthogonality.For the model comparison approach the main drawback is the dependence of the hypothesis tested on the cell sizes. In this paper we provide examples to illustrate these drawbacks.     

Parameter estimation in nonlinear regression models 1

Fisher information contained in record values, inter-record times and their concomitants from a sample of fixed size is derived in general and explicit expressions are deduced for some specific known bivariate classes of distributions. A comparison between fixed sampling and inverse sampling schemes with equal number of records and concomitants is also carried out. We also consider parameter estimation based on bivariate records and a small simulation study is done.     

Choice of Parametric Accelerated Life and Proportional Hazards Models for Survival Data: Asymptotic Results

We discuss the impact of misspecifying fully parametric proportional hazards and accelerated life models. For the uncensored case, misspecified accelerated life models give asymptotically unbiased estimates of covariate effect, but the shape and scale parameters depend on the misspecification. The covariate, shape and scale parameters differ in the censored case. Parametric proportional hazards models do not have a sound justification for general use: estimates from misspecified models can be very biased, and misleading results for the shape of the hazard function can arise. Misspecified survival functions are more biased at the extremes than the centre. Asymptotic and first order results are compared. If a model is misspecified, the size of Wald tests will be underestimated. Use of the sandwich estimator of standard error gives tests of the correct size, but misspecification leads to a loss of power. Accelerated life models are more robust to misspecification because of their log-linear form. In preliminary data analysis, practitioners should investigate proportional hazards and accelerated life models; software is readily available for several such models.     

Marginal Regression of Gaps Between Recurrent Events

Recurrent event data typically exhibit the phenomenon of intra-individual correlation, owing to not only observed covariates but also random effects. In many applications, the population may be reasonably postulated as a heterogeneous mixture of individual renewal processes, and the inference of interest is the effect of individual-level covariates. In this article, we suggest and investigate a marginal proportional hazards model for gaps between recurrent events. A connection is established between observed gap times and clustered survival data with informative cluster size. We subsequently construct a novel and general inference procedure for the latter, based on a functional formulation of standard Cox regression. Large-sample theory is established for the proposed estimators. Numerical studies demonstrate that the procedure performs well with practical sample sizes. Application to the well-known bladder tumor data is given as an illustration.