A modified false discovery rate multiple-comparisons procedure for discrete data, applied to human immunodeficiency virus genetics

Summary.  To help to design vaccines for acquired immune deficiency syndrome that protect broadly against many genetic variants of the human immunodeficiency virus, the mutation rates at 118 positions in HIV amino-acid sequences of subtype C versus those of subtype B were compared. The false discovery rate (FDR) multiple-comparisons procedure can be used to determine statistical significance. When the test statistics have discrete distributions, the FDR procedure can be made more powerful by a simple modification. The paper develops a modified FDR procedure for discrete data and applies it to the human immunodeficiency virus data. The new procedure detects 15 positions with significantly different mutation rates compared with 11 that are detected by the original FDR method. Simulations delineate conditions under which the modified FDR procedure confers large gains in power over the original technique. In general FDR adjustment methods can be improved for discrete data by incorporating the modification proposed.     

Progress and cumulation in the human sciences after the fall

What do we mean by progress and cumulation in the social and human sciences? Recent thinking in the philosophy and history of science has led to an abandonment of some versions of logical positivism and of verificationism that had a strong deductive and theory testing orientation. What is to replace them is less clear. This paper argues that progress and cumulation can be seen as a process of evaluation and retention within an epistemic community. Scholarly disciplines differ in their social structure and in their epistemic and normative commitments. Since sociology is a fragmented discipline, progress and cumulation differ within its multiple subdisciplines, which to varying extents represent epistemic communities. Brief sketches of progress (advance) and cumulation in several subdisciplines are offered.     

语言冗余现象在英语教学中的作用初探

冗余是人类语言的固有特征。冗余现象的研究在语言学中占据重要地位,它对语言教学的影响也日益受到重视。本文利用语言测试手段,通过实验验证了冗余理论在英语教学中的积极作用     

两种非理性生存哲学表现论--略论陀氏作品中的蛆和虱子意象

陀思妥耶夫斯基善于挖掘人物的自我意识和矛盾、分裂的心理世界。对他来说,重要的不是主人公在世界上是什么,而首先是世界在主人公心中是什么。他的小说文本通过意识与现实的切换、对内对外两种话语指向的交融以及场面化的激烈辩驳,表现出了主人公们反传统理性的生存哲学。《地下室手记》的主人公和《罪与罚》的主人公正是这种与世俗理性抗争的自我折磨的英雄。     

新时代法治信仰建设:价值指向、心理机制与实践路径

法治信仰是现代法律信仰的核心,是对社会主义法治理念的充分信任和法律制度的自觉遵从。习近平法治思想作为我国法治建设的指导思想,为新时代中国特色社会主义法治信仰建设提供了价值指向,要以“五个坚持”为指导,营造有利于法治信仰生成的政治环境。从法治信仰的心理机制来看,人民群众在对法治价值有了初步认可后,便在价值体验的催化下形成法治价值观,继而在科学公正的立法、执法、司法、守法过程中坚定法治信念,实现法治信仰的升华。要引导全体人民拥护法治、做社会主义法治的忠实崇尚者和捍卫者,在立法、执法、司法以及法治宣传等实践中大力推进新时代法治信仰建设。     

The design of organizations and the right to act

Recent innovations in the structure of formal organizations suggest possible directions for the design of schools to bring about high achievement. The structure of output-driven in contrast to administratively-driven schools is described, and designs are described which address both the goal of high achievement and the goal of reduced inequality.An earlier version of this paper was presented as the author's Sorokin Lecture at the annual meeting of the Eastern Sociological Society, Boston, March 1993.     

经济收敛理论与检验方法研究综述

在大量文献研究的基础上,对收敛问题的产生及收敛概念的发展作了全面概括,并对绝对收敛、条件收敛、俱乐部收敛和σ收敛作了深入辨析,对各种识别方法作了全面归纳。归纳了对世界大多数国家和地区数据所作识别的结果。还从收敛理论与传统理论的冲突与协调方面作了深入分析。最后对近年收敛研究的深化与扩展研究的趋势作了概括。     

大学生专业承诺的实证研究

通过研究发现,大学生专业承诺的心理结构包含了4个基本维度,它们分别是感情承诺、经济承诺、规范承诺和机会承诺。依据大学生专业承诺的心理结构编制出的"大学生专业承诺问卷",通过施测结果表明问卷具有良好的信、效度,能够作为大学生专业承诺状况有效、合理的评价工具。同时,研究者还采用回归分析方法进一步考察了大学生专业承诺与专业满意感、学业成效以及转专业意向等变量之间的关系。研究结果表明,大学生对专业的感情承诺或经济承诺增强,那么他们对专业的满意感就会提高,他们也将更有可能获得较好的学习效果。进一步研究发现,大学生专业承诺与转专业意向存在着显著的负相关,而与大学生学业卷入度存在着显著的正相关,这样,大学生专业承诺水平可以作为大学生转专业意向和学业专业度的预测指标,为大学生专业承诺咨询和干预提供理论依据。     

海南省大学生网络成瘾和心理健康水平研究

以海南省3所高校的421名在校非体育专业本科生为研究对象,并与体育专业本科生的网络成瘾情况进行对比研究,所有数据均采用SPSS11软件进行统计分析。结果表明：体育生的网络成瘾现象均高于文科生和理科生,而文科生又高于理科生;理科生网络成瘾者的心理健康水平均高于体育生和文科生,体育生则高于文科生。     

知识型员工流失的深层研究——基于心理契约的视角

知识型员工由于其地位和作用的特殊性,一直是企业竞争的主要对象,其流动率也一直较高。知识型员工流失在很大程度上是心理契约违背的必然结果,因此,重构和优化心理契约至关重要。具体而言,在招聘、入职、变动和离职四个阶段,企业应分别采取真实岗位预视、建立动态档案、加强沟通、及时补偿和离职面谈等措施,防止知识型员工流失。