A measure of robust slope-rotatability for second-order response surface experimental designs

In response surface methodology, rotatability and slope-rotatability are natural and highly desirable properties for second-order regression models. In this paper a measure of robust slope-rotatability for second-order response surface designs with a general correlated error structure is developed and illustrated with different examples for autocorrelated error structure.     

Bias Reduction in Logistic Regression with Missing Responses When the Missing Data Mechanism is Nonignorable

ABSTRACT

In logistic regression with nonignorable missing responses, Ibrahim and Lipsitz proposed a method for estimating regression parameters. It is known that the regression estimates obtained by using this method are biased when the sample size is small. Also, another complexity arises when the iterative estimation process encounters separation in estimating regression coefficients. In this article, we propose a method to improve the estimation of regression coefficients. In our likelihood-based method, we penalize the likelihood by multiplying it by a noninformative Jeffreys prior as a penalty term. The proposed method reduces bias and is able to handle the issue of separation. Simulation results show substantial bias reduction for the proposed method as compared to the existing method. Analyses using real world data also support the simulation findings. An R package called brlrmr is developed implementing the proposed method and the Ibrahim and Lipsitz method.     

Empirical likelihood for linear regression models under imputation for missing responses

The authors study the empirical likelihood method for linear regression models. They show that when missing responses are imputed using least squares predictors, the empirical log‐likelihood ratio is asymptotically a weighted sum of chi‐square variables with unknown weights. They obtain an adjusted empirical log‐likelihood ratio which is asymptotically standard chi‐square and hence can be used to construct confidence regions. They also obtain a bootstrap empirical log‐likelihood ratio and use its distribution to approximate that of the empirical log‐likelihood ratio. A simulation study indicates that the proposed methods are comparable in terms of coverage probabilities and average lengths of confidence intervals, and perform better than a normal approximation based method.     

Statistical methods to evaluate health effects associated with major sources of air pollution: a case-study of breathing patterns during exposure to concentrated Boston air particles

Summary.  We conduct a case-study evaluating the source-specific effects of particulate matter on respiratory function. Using a structural equation approach, we assess the effect of different receptor models on the estimated source-specific effects for univariate respiratory response. Furthermore, we extend the structural equation model by placing a factor analysis model on the response to represent the measured respiratory responses in terms of underlying respiratory patterns. We estimate the particulate matter source-specific effects on respiratory rate, accentuated normal breathing and airway irritation and find a strong increase in airway irritation that is associated with exposure to motor vehicle particulate matter.     

Generalized spectral tests for serial dependence

Two tests for serial dependence are proposed using a generalized spectral theory in combination with the empirical distribution function. The tests are generalizations of the Cramér-von Mises and Kolmogorov-Smirnov tests based on the standardized spectral distribution function. They do not involve the choice of a lag order, and they are consistent against all types of pairwise serial dependence, including those with zero autocorrelation. They also require no moment condition and are distribution free under serial independence. A simulation study compares the finite sample performances of the new tests and some closely related tests. The asymptotic distribution theory works well in finite samples. The generalized Cramér-von Mises test has good power against a variety of dependent alternatives and dominates the generalized Kolmogorov-Smirnov test. A local power analysis explains some important stylized facts on the power of the tests based on the empirical distribution function.     

Doubly adaptive biased coin designs with delayed responses

In clinical studies, patients are usually accrued sequentially. Response‐adaptive designs are then useful tools for assigning treatments to incoming patients as a function of the treatment responses observed thus far. In this regard, doubly adaptive biased coin designs have advantageous properties under the assumption that their responses can be obtained immediately after testing. However, it is a common occurrence that responses are observed only after a certain period of time. The authors examine the effect of delayed responses on doubly adaptive biased coin designs and derive some of their asymptotic properties. It turns out that these designs are relatively insensitive to delayed responses under widely satisfied conditions. This is illustrated with a simulation study.     

Graphical methods for evaluating ridge regression estimator in mixture experiments

When the component proportions in mixture experiments are restricted by lower and upper bounds, multicollinearity appears all too frequently. Thus, we can suggest the use of ridge regression as a mean for stabilizing the coefficient estimates in the fitted model. We propose graphical methods for evaluating the effect of ridge regression estimator with respect to the predicted response value and the prediction variance.     

Calibration for Randomized Response Estimators

In the present article, we consider the calibration procedure for the Warner's and Mangat–Singh's (:M–S) randomized response survey estimators using auxiliary information associated with the variable of interest. In the calibration procedure, we can use auxiliary information such as age, gender, and income for the respondents of RR questions from an external source, and then the classical RR estimators can be improved with respect to the problems of noncoverage or nonresponse. From the efficiency comparison study, we show that the calibration estimators are more efficient than those of Warner's and Mangat-Singh's when the known population cell and marginal counts of auxiliary information are used for the calibration procedure.     

On the use of multi-auxiliary variables to neutralize the effect of non response in two-occasion successive sampling

In this work, we have suggested some linear combinations of generalized ratio type estimators in estimation of current population mean when non response occur in two occasion successive sampling. Information on multi-auxiliary variables has been used and sub-sampling of non respondents technique is utilized to cope with the negative effect of non response. Properties of the suggested estimation procedures have been examined and suitable optimum replacement strategies are discussed. Empirical studies are carried out to justify the proposition of estimators. Suitable recommendations have been made.     

Missing Data Mechanisms for Analysing Longitudinal Data with Incomplete Observations in Both Responses and Covariates

Missing observations in both responses and covariates arise frequently in longitudinal studies. When missing data are missing not at random, inferences under the likelihood framework often require joint modelling of response and covariate processes, as well as missing data processes associated with incompleteness of responses and covariates. Specification of these four joint distributions is a nontrivial issue from the perspectives of both modelling and computation. To get around this problem, we employ pairwise likelihood formulations, which avoid the specification of third or higher order association structures. In this paper, we consider three specific missing data mechanisms which lead to further simplified pairwise likelihood (SPL) formulations. Under these missing data mechanisms, inference methods based on SPL formulations are developed. The resultant estimators are consistent, and enjoy better robustness and computation convenience. The performance is evaluated empirically though simulation studies. Longitudinal data from the National Population Health Survey and Waterloo Smoking Prevention Project are analysed to illustrate the usage of our methods.