Measurement Error Correction by Exploiting Gene–Environment Independence in Family‐Based Case–Control Studies

Abstract. Family‐based case–control designs are commonly used in epidemiological studies for evaluating the role of genetic susceptibility and environmental exposure to risk factors in the etiology of rare diseases. Within this framework, it is often reasonable to assume genetic susceptibility and environmental exposure being conditionally independent of each other within families in the source population. We focus on this setting to explore the situation of measurement error affecting the assessment of the environmental exposure. We correct for measurement error through a likelihood‐based method. We exploit a conditional likelihood approach to relate the probability of disease to the genetic and the environmental risk factors. We show that this approach provides less biased and more efficient results than that based on logistic regression. Regression calibration, instead, provides severely biased estimators of the parameters. The comparison of the correction methods is performed through simulation, under common measurement error structures.     

论新闻计算句子长短的句子标准

新闻语体的句子应该比其他语体的句子短，这是由新闻的易读性决定的。但是目前的一些新闻语言研究中，统计出的句子比其他语体的句子还要长几倍。一些新闻语言研究中同时以单句和复句为单位。单句和复句在语法结构上不是同一层级的语言单位，同时作为计算单位，是违反逻辑的。语法系统中，小句是基本的句子，是传递信息的基本单位。新闻语言研究中也应以小句为计算单位。     

Assessing direct and indirect seasonal decomposition in state space

The problem of whether seasonal decomposition should be used prior to or after aggregation of time series is quite old. We tackle the problem by using a state-space representation and the variance/covariance structure of a simplified one-component model. The variances of the estimated components in a two-series system are compared for direct and indirect approaches and also to a multivariate method. The covariance structure between the two time series is important for the relative efficiency. Indirect estimation is always best when the series are independent, but when the series or the measurement errors are negatively correlated, direct estimation may be much better in the above sense. Some covariance structures indicate that direct estimation should be used while others indicate that an indirect approach is more efficient. Signal-to-noise ratios and relative variances are used for inference.     

网上银行顾客感知服务质量影响因素研究

通过文献研究和深度访谈，提炼出可能影响网上银行顾客感知服务质量的19个因素，通过探索性因子分析，将这19个因素归纳为经济性、易用性、履行性、安全性和响应性。通过相关分析和多元回归分析发现，有4类因素与网上银行顾客感知服务质量呈显著正相关，依次是经济性、易用性、履行性和安全性。通过对我国主要网上银行服务质量测评发现，当前我国网上银行服务质量不高，且各家网上银行服务质量存在明显差异。     

Investigating the Structural Validity of Ryff’s Psychological Well-Being Scales Across Two Samples

Ryff’s (1989b) Psychological Well-Being (PWB) scales measure six related constructs of human functioning. The present paper examined the validity of Ryff’s 6-factor PWB model, using data from a life events study (N = 401) and an organisational climate study (N = 679). Previous validation studies, using Confirmatory Factor Analysis (CFA), have identified alternative PWB models, but limitations include the use of shorter scale versions with items relating to a number of life domains within the same PWB factor, and failure to examine the influence of participants’ socio-demographic characteristics on PWB. In this study, Exploratory Factor Analysis (EFA) mostly found consistency in the PWB items and structure between the two studies whereby a 3-factor model delineated between items relating to Autonomy, Positive Relations and a super-ordinate factor comprising the other PWB factors. Using CFA, Goodness of Fit indices reached acceptable levels for the adjusted PWB model identified by the EFA, whilst differences between adjusted models of PWB previously identified in the literature were hardly evident. Post-hoc analysis by gender demonstrated socio-demographic effects on the structure and items that comprise PWB. Further development of PWB measures is needed to reflect its hierarchical and multi-dimensional nature. In the scales’ current form, the construct validation of the PWB factors will continue to be problematic and will fail to adequately evaluate the nature and impact of PWB.     

A time-varying measurement error model for age of onset of a psychiatric diagnosis: applied to first depressive episode diagnosed by the Composite International Diagnostic Interview (CIDI)

A substantial degree of uncertainty exists surrounding the reconstruction of events based on memory recall. This form of measurement error affects the performance of structured interviews such as the Composite International Diagnostic Interview (CIDI), an important tool to assess mental health in the community. Measurement error probably explains the discrepancy in estimates between longitudinal studies with repeated assessments (the gold-standard), yielding approximately constant rates of depression, versus cross-sectional studies which often find increasing rates closer in time to the interview. Repeated assessments of current status (or recent history) are more reliable than reconstruction of a person's psychiatric history based on a single interview. In this paper, we demonstrate a method of estimating a time-varying measurement error distribution in the age of onset of an initial depressive episode, as diagnosed by the CIDI, based on an assumption regarding age-specific incidence rates. High-dimensional non-parametric estimation is achieved by the EM-algorithm with smoothing. The method is applied to data from a Norwegian mental health survey in 2000. The measurement error distribution changes dramatically from 1980 to 2000, with increasing variance and greater bias further away in time from the interview. Some influence of the measurement error on already published results is found.     

The classification accuracy of four problem gambling assessment instruments in population research

Improved methodology was used to re-examine the weak correspondence between problem and pathological gamblers identified in population surveys and subsequent classification of these individuals in clinical interviews. The SOGS-R, the CPGI, the NODS and the Problem and Pathological Gambling Measure (PPGM), as well as questions about gambling participation and expenditures, were administered to a total of 7272 adults. Two clinicians then assessed each person's status, based on comprehensive written profiles derived from these questionnaire responses. Instrument classification was then compared to clinical classification. All four instruments correctly classified most non-problem gamblers (i.e. had good to excellent sensitivity, specificity and negative predictive power). However, the PPGM was the only instrument with good classification of problem gamblers (i.e. excellent sensitivity and positive predictive power). The CPGI and SOGS-R had weak positive predictive power and the NODS had only adequate sensitivity and positive predictive power. Improvement in the classification accuracy of the CPGI occurred when a 5+ cut-off was used and when a 4+ cut-off was used with the SOGS. In general, the classification accuracy of the NODS, SOGS and CPGI is better than prior research suggested but overall accuracy is still modest. With adjusted cut-offs, all three instruments are reasonably congruent with clinical ratings.     

Reflections on Changes in the Library and Serials Literature

Abstract

Johnson describes changes in library journal literature topics over the past one hundred years, with a focus on the period between her first Balance Point column in 2003 and this one, her last. She reminisces on her experience as a Balance Point column editor.     

On the improvement of one-sided S control charts

The most common charting procedure used for monitoring the variance of the distribution of a quality characteristic is the S control chart. As a Shewhart-type control chart, it is relatively insensitive in the quick detection of small and moderate shifts in process variance. The performance of the S chart can be improved by supplementing it with runs rules or by varying the sample size and the sampling interval. In this work, we introduce and study one-sided adaptive S control charts, supplemented or not with one powerful runs rule, for detecting increases or decreases in process variation. The properties of the proposed control schemes are obtained by using a Markov chain approach. Furthermore, a practical guidance for the choice of the most suitable control scheme is also provided.     

BOOST－PFC电路反馈环节的优化设计

介绍了平均电流控制ＢＯＯＳＴ─ＰＦＣ电路的原理，建立了电流环和电压环的小信号简化模型，讨论了双环反馈环节的设计原则和方法，提出最优设计的思想和数学模型，并以一种ＢＯＯＳＴ─ＰＦＣ电路为例进行优化设计，计算模拟结果显示优化后有关指标好于优化前。