Genetic variants in 5p13.2 and 7q21.1 are associated with treatment for benign prostatic hyperplasia with the α-adrenergic receptor antagonist

Background: The etiology of benign prostatic hyperplasia (BPH) has not been well established. The preferred medical treatment for many men with symptomatic benign prostatic hyperplasia is either an α-adrenergic receptor antagonist (α-blocker), or a 5α-reductase inhibitor. Single nucleotide polymorphism (SNP) is a powerful tool for successful implementation of individualized treatment.

Methods: Eighteen SNPs associated with drug efficacy in a Chinese population were genotyped in 790 BPH cases (330 aggressive and 460 non-aggressive BPH cases) and 1008 controls. All BPH patients were treated with α-adrenergic blockers for at least 9 months. We tested the associations between tagging single nucleotide polymorphism and BPH risk/aggressiveness, clinical characteristics at baseline, including the International Prostate Symptom Score (IPSS) and total prostate volume, and changes in clinical characteristics after treatment.

Results: There were nine SNPs associated with BPH risk, clinical progression and therapeutic effect. (1) There were nine tSNPs been chosen in CYP3A4, CYP3A5 and RANBP3L genes. (2) The SNP, rs16902947 in RANBP3L at 5p13.2 (p?=?.01), was significantly associated with BPH. (3) We found two SNPs, rs16902947 in RANBP3L at 5p13.2 (p?=?.0388) and rs4646437 in CYP3A4 at 7q21.1 (p?=?.0325), associated with drug effect. (4) Allele “G” for rs16902947 was found to be risk alleles for BPH risk (OR=?2.357, 95%CI 1.01–1.48). The “A” allele of rs4646437 was associated with lower IPSS at baseline (β=??0.4232, p=?.03255).

Conclusions: rs16902947, rs16902947 and rs4646437 single nucleotide polymorphisms are significantly associated with the clinical characteristics of benign prostatic hyperplasia and the efficacy of benign prostatic hyperplasia treatment.     

Analysis of Double Single Index Models

Motivated from problems in canonical correlation analysis, reduced rank regression and sufficient dimension reduction, we introduce a double dimension reduction model where a single index of the multivariate response is linked to the multivariate covariate through a single index of these covariates, hence the name double single index model. Because nonlinear association between two sets of multivariate variables can be arbitrarily complex and even intractable in general, we aim at seeking a principal one‐dimensional association structure where a response index is fully characterized by a single predictor index. The functional relation between the two single‐indices is left unspecified, allowing flexible exploration of any potential nonlinear association. We argue that such double single index association is meaningful and easy to interpret, and the rest of the multi‐dimensional dependence structure can be treated as nuisance in model estimation. We investigate the estimation and inference of both indices and the regression function, and derive the asymptotic properties of our procedure. We illustrate the numerical performance in finite samples and demonstrate the usefulness of the modelling and estimation procedure in a multi‐covariate multi‐response problem concerning concrete.     

企业所得税诚信纳税单因素分析模型的设计及应用——以山东省外商投资企业为例

外资企业纳税是否诚信将直接影响到我国吸引外资的质量和水平。当前外商投资企业偷逃所得税的情况较为严重,而当前我国关于诚信纳税的理论还不很完善,专门针对所得税诚信纳税的研究更为缺乏。采用规范性分析和实证性分析相结合的方法,以山东省外商投资企业为例进行研究提出所得税诚信纳税单因素分析模型,研究结果表明：在税收弹性大于等于平均税负时企业诚信纳税,诚信纳税度较高;而在税收弹性小于平均税负时企业存在非诚信纳税行为,诚信纳税度较低。     

The Influence of Grandparents in Single‐Mother Families

This article examines whether children living with single mothers benefit when they also live with a grandparent, using data from the 1979 to 2002 waves of the National Longitudinal Survey of Youth merged mother‐child file (N = 6,501). Results indicate that for White children, living with a single mother and a grandparent is associated with increased cognitive stimulation and higher reading recognition scores, compared to living with a single mother alone. For Black children, grandparent coresidence is associated with less cognitive stimulation. Thus, in some instances, living with a grandparent can benefit children, but the pattern of results differs by race.     

Single,Cohabitating, and Married Mothers’ Time With Children

Utilizing the 2003 and 2004 American Time Use Survey (ATUS), this study examines the relationship between family structure and maternal time with children among 4,309 married mothers and 1,821 single mothers with children less than 13 years of age. Single mothers spend less time with their children than married mothers, though the differences are not large. Marital status and living arrangement differences in time with children largely disappear or single mothers engage in more child care than married mothers after controls for socioeconomic status and other characteristics are introduced. Thus, less maternal time with children appears to be mainly attributable to the disadvantaged social structural location of single mothers rather than different proclivities toward mothering between married and single mothers.     

Power comparisons of single-sample winsorized T,trimmed T and student's T

The objective of this study is to evaluate the performance of Winsorized t which was proposed to be used as one alternative to the student's t statistic when the parent population is non-normal. The criterion we use is the power of the test. Comparative performance of the Winsorized t, trimmed t, and Studen$tCs t for normal populations and for Studen$tCs t distribution with 8, 4, and 2 degrees of freedom was investigated.     

高分辨率彩管封口机电子枪激光自动对准系统

提出了一种激光自动对准系统,可用于彩管封口机中电子枪相对于屏面的定位。该系统由激光器、激光准直部分、传感器、单片机控制系统、驱动电路及专用减速器组成,在单片机控制系统的控制下,自动完成电子枪的定位任务。模拟实验证明该定位方法完全能在要求的定位精度内实现电子枪的自动定位。     

三相专用电源屏的监测与控制系统设计

单相变三相的转辙机专用电源屏是铁路提速的关键设备之一,为保证转辙机可靠工作和列车的安全运行,该文提出了一种转辙机专用电源屏故障监控系统,详细介绍了测控系统中硬件系统的组成和系统功能,并论述了调压器工作原理以及软件设计方案。现场测试表明,其测控系统对提高转辙机电源屏运行效率和可靠性具有重要作用。     

单模光纤中光的偏振

分析了单模光纤中光的偏振特性以及偏振光学在光纤中的应用     

Mothers' work–to–family strain in single and couple parent families: the role of job characteristics and supports

For parents there can be negative aspects of how work ‘spills over’ to family. This analysis focuses on mothers of young children and considers how aspects of work–to–family strain differ for single and couple mothers. While there has been increased focus on the work–family strains of mothers, less is known about single mothers and their experience of work–family strain. We might expect that single mothers would have more difficulty in combining work and family, given that they do not have the support of a resident partner to assist with childrearing responsibilities. This paper explores the relationships between several demographic, employment and supports factors and work–family strain. It also examines whether these associations are different according to family form; that is, whether certain factors make the work–family balance significantly worse or better for single mothers than for otherwise similar couple‐parent mothers. The analysis is based on the 2004 Growing up in Australia: the Longitudinal Study of Australian Children (LSAC). This dataset contains detailed family and child data for around 10,000 families, all with at least one child aged 5 or under. With such a large sample size, the number of single mothers is sufficiently large to enable more analyses than is often possible from survey data.