Optimum Mixture Design for the Detection of Synergistic Effects

In mixture experiments, optimal designs for the estimation of parameters, both linear and non-linear, have been discussed by several authors. Optimal designs for the estimation of a subset of parameters have also been investigated. However, designs for testing the effects of certain factors and interactions have been studied only in the context of response surface models. In this article, we attempt to find the optimum design for testing the presence of synergistic effects in a mixture model. The classical F-test has been considered and the optimum design has been obtained so as to maximize the power of the test. It is observed that the barycenters are necessarily the support points of the trace-optimal design.     

On approximating a linear combination of central wishart matrices with positive coefficients

Consider linear combinations of central Wishart matrices with positive coefficients. By equating the expected values and the generalized variance of variances and covariances, we propose approximating the distributions of those linear combinations by central Wishart distributions. Some Monte Carlo results are given to demonstrate the closeness of this approximation.     

A review of uniform cross-over designs

Uniform cross-over designs form an important family of experimental designs. They have been applied in many scientific disciplines including clinical trials, agricultural studies and psychological experiments. In this paper we consider the four types of uniform cross-over design, as given by Williams [1949. Experimental designs balanced for the estimation of residual effects of treatments. Aust. J. Sci. Res. 2, 149–168], Cheng and Wu [1980. Balanced repeated measurements designs. Ann. Statist. 8, 1272–1283. Corrigendum 11 (1983) 349], Bate and Jones [2006. The construction of nearly balanced and nearly strongly balanced uniform cross-over designs. J. Statist. Plann. Inference 136, 3248–3267] and Kunert [1983. Optimal design and refinement of the linear model with applications to repeated measurements designs. Ann. Statist. 11, 247–257]. The efficiency of these designs, existence criteria and methods of construction are described.     

Lad for Multiway Tables

It is shown that transformations based on differencing can be helpful in simplifying the problem of fitting to multiway tables. This is illustrated for LAD fitting, and the computational problems surveyed briefly.     

Optimal 2n-p fractional factorial designs for dispersion effects under a location-diapersion model

We consider main effects models for 2-level experiments that also include. Parameters characterizing potential dispersion effects due to specified factors. One special case is considered. In this case only a single specified factor is responsible for the dispersion effects. We determine the connection between alias relations and Optimality of a design for estimation of dispersion effects in the class of regu!ar fractional Y - P factorial designs of resolution III or higher. This rmectioil heips US identify those designs that are A-optimal for estimating dispersion effects by a suitable choice of defining contrasts. in particuiar, we show that an increase in efficiency with respect to dispersion effects is accompanied by a loss iii efficiency for estimating the location effects. In practice, one mmt thcrcfcre accept a trade& between the efficiencies associated with estirnates of location effects and dispersion effects.     

Unemployment and crime: A neighborhood level panel data approach

Twenty-five years ago, David Cantor and Kenneth Land presented a model of the relationship between unemployment and crime. This model showed the complexity of this seemingly simple relationship. Namely, there are two independent and counteracting effects from unemployment that affect crime: motivation and guardianship. In their analysis, Cantor and Land found that the guardianship effect dominates the motivation effect, but subsequent research has questioned this result. In this paper, the unemployment and crime relationship is tested using a neighborhood level hybrid modeling approach. Such a method allows for the nuances of Cantor and Land’s model to be tested at a fine ecological resolution for the first time. It is found that both motivation and guardianship matter for crime, but at different time frames: motivation matters in the long-run whereas guardianship matters in the short-run, similar to what Cantor and Land hypothesized.     

Bootstrap methods for the nonparametric assessment of population bioequivalence and similarity of distributions

A completely nonparametric approach to population bioequivalence in crossover trials has been suggested by Munk and Czado (1999). It is based on the Mallows (1972) metric as a nonparametric distance measure which allows the comparison between the entire distribution functions of test and reference formulations. It was shown that a separation between carry-over and period effects is not possible in the nonparametric setting. However when carry-over effects can be excluded, treatment effects can be assessed when period effects are or not. Munk and Czado (1999) proved bootstrap limit laws of the corresponding test statistics because estimation of the limiting variance of the test statistic is very cumbersome. The purpose of this paper is to investigate the small sample behavior of various bootstrap methods and to compare it with the asymptotic test obtained by estimation of the limiting variance. The percentile (PC) and bias correct- ed and accelerated (BCA) bootstrap were compared for multivariate normal and nonnormal populations. From the simulation results presented, the BCA bootstrap is found to be less conservative and provides higher power compared to the PC bootstrap, especially when skewed multivariate populations are present.     

On familial Poisson mixed models with multi-dimensional random effects

When a generalized linear mixed model with multiple (two or more) sources of random effects is considered, the inferences may vary depending on the nature of the random effects. In this paper, we consider a familial Poisson mixed model where each of the count responses of a family are influenced by two independent unobservable familial random effects with two distinct components of dispersion. A generalized quasilikelihood (GQL) approach is discussed for the estimation of the dispersion components as well as the regression effects of the model. A simulation study is conducted to examine the relative performance of the GQL approach as opposed to a simpler method of moments. Furthermore, the GQL estimation methodology is illustrated by using health care utilization data that follow a Poisson mixed model with one component of dispersion and by using simulated asthma data that follow a Poisson mixed model with two sources of random effects with two distinct components of dispersion.     

Hierarchical Bayes estimation in small area estimation using cross-sectional and time-series data

Bayesian methods have been extensively used in small area estimation. A linear model incorporating autocorrelated random effects and sampling errors was previously proposed in small area estimation using both cross-sectional and time-series data in the Bayesian paradigm. There are, however, many situations that we have time-related counts or proportions in small area estimation; for example, monthly dataset on the number of incidence in small areas. This article considers hierarchical Bayes generalized linear models for a unified analysis of both discrete and continuous data with incorporating cross-sectional and time-series data. The performance of the proposed approach is evaluated through several simulation studies and also by a real dataset.     

Outlier detection and robust estimation in linear regression models with fixed group effects

This work studies outlier detection and robust estimation with data that are naturally distributed into groups and which follow approximately a linear regression model with fixed group effects. For this, several methods are considered. First, the robust fitting method of Peña and Yohai [A fast procedure for outlier diagnostics in large regression problems. J Am Stat Assoc. 1999;94:434–445], called principal sensitivity components (PSC) method, is adapted to the grouped data structure and the mentioned model. The robust methods RDL₁ of Hubert and Rousseeuw [Robust regression with both continuous and binary regressors. J Stat Plan Inference. 1997;57:153–163] and M-S of Maronna and Yohai [Robust regression with both continuous and categorical predictors. Journal of Statistical Planning and Inference 2000;89:197–214] are also considered. These three methods are compared in terms of their effectiveness in outlier detection and their robustness through simulations, considering several contamination scenarios and growing contamination levels. Results indicate that the adapted PSC procedure is able to detect a high percentage of true outliers and a small number of false outliers. It is appropriate when the contamination is in the error term or in the covariates, detecting also possibly masked high leverage points. Moreover, in simulations the final robust regression estimator preserved good efficiency under Normality while keeping good robustness properties.