Intuitive Toxicology: Expert and Lay Judgments of Chemical Risks

Human beings have always been intuitive toxicologists, relying on their senses of sight, taste, and smell to detect harmful or unsafe food, water, and air. As we have come to recognize that our senses are not adequate to assess the dangers inherent in exposure to a chemical substance, we have created the sciences of toxicology and risk assessment to perform this function. Yet despite this great effort to overcome the limitations of intuitive toxicology, it has become evident that even our best scientific methods still depend heavily on extrapolations and judgments in order to infer human health risks from animal data. Many observers have acknowledged the inherent subjectivity in the assessment of chemical risks and have indicated a need to examine the subjective or intuitive elements of expert and lay risk judgments. We have begun such an examination by surveying members of the Society of Toxicology and the lay public about basic toxicological concepts, assumptions, and interpretations. Our results demonstrate large differences between toxicologists and laypeople, as well as differences between toxicologists working in industry, academia, and government. In addition, we find that toxicologists are sharply divided in their opinions about the ability to predict a chemical's effect on human health on the basis of animal studies. We argue that these results place the problems of risk communication in a new light. Although the survey identifies misconceptions that experts should clarify for the public, it also suggests that controversies over chemical risks may be fueled as much by limitations of the science of risk assessment and disagreements among experts as by public misconceptions.     

Professional Perspectives on Decision Making about the Long-term Care of Older People

With the increasing pressure on social and health care resources,professionals have to be more explicit in their decision makingregarding the long-term care of older people. This groundedtheory study used 19 focus groups and nine semi-structured interviews(99 staff in total) to explore professional perspectives onthis decision making. Focus group participants and intervieweescomprised care managers, social workers, consultant geriatricians,general medical practitioners, community nurses, home care managers,occupational therapists and hospital discharge support staff.The emerging themes spanned context, clients, families and services.Decisions were often prompted by a crisis, hindering professionalsseeking to make a measured assessment. Fear of burglary andassault, and the willingness and availability of family to helpwere major factors in decisions about living at home. Serviceavailability in terms of public funding for community care,the availability of home care workers and workload pressureson primary care services influenced decision ‘thresholds’regarding admission to institutional care. Assessment toolsdesigned to assist decision making about the long-term careof older people need to take into account the critical aspectsof individual fears and motivation, family support and the availabilityof publicly funded services as well as functional and medicalneeds.     

Two point priors and Γ-minimax estimating in families of uniform distributions

It is shown that when a parameter lying in a sufficiently small interval is to be estimated in a family of uniform distributions, a two point prior is least favourable under squared error loss. The unique Bayes estimator with respect to this prior is minimax. The Γ-minimax estimator is derived for sets Γ of priors consisting of all priors that give fixed probabilities to two specified subintervals of the parameter space if a two point prior is least favourable in Γ.     

The design of organizations and the right to act

Recent innovations in the structure of formal organizations suggest possible directions for the design of schools to bring about high achievement. The structure of output-driven in contrast to administratively-driven schools is described, and designs are described which address both the goal of high achievement and the goal of reduced inequality.An earlier version of this paper was presented as the author's Sorokin Lecture at the annual meeting of the Eastern Sociological Society, Boston, March 1993.     

Identifying and implementing pathways for organizational change – using the Framework for the Assessment of Children in Need and their Families as a case example

Change within social work organizations is incessant. This has implications for senior managers and elected members who have to manage these changes. The Department of Health has introduced new guidance entitled the Framework for the Assessment of Children in Need and their Families ( Department of Health 1999a ). The guidance is based on a number of principles that require an attitudinal shift in terms of assessing ways of safeguarding children and promoting their welfare. This paper describes strategic approaches to the effective introduction of the framework within social services departments and other child welfare organizations. Two models have been adapted from practice: the actual framework for assessing children and their families and the Protchaska and DiClementi model of change. These models complement each other. The adapted Assessment Framework provides a structure to assess the readiness of the organization for the implementation of the new framework. The model of change provides a schema for planning, implementing and reviewing the introduction and operation of the Framework for the Assessment of Children in Need and their Families. Although the focus of the paper is the introduction of the new guidance , the models can be utilized by senior managers in any social care organization who are facilitating major changes in the organization.     

"启蒙理性的审美置换"——论《哦,香雪》、《没有纽扣的红衬衫》的现代性及其文学史地位

以新时期初期的文学实践为背景,从现代性的视野中考察铁凝作为启蒙知识分子身份认同及其创作,可以揭示在80年代特殊的历史时刻和政治意识形态空间中,铁凝与其他知识分子由于身份、代际和经历不同所造成的不同的文学话语和意义。铁凝初期创作中以强烈的知识分子主体意识和理性启蒙精神,通过对少女香雪、安然的塑造建构了真正意义上现代性的独立人格和自我主体形象,使《哦,香雪》、《没有纽扣的红衬衫》在新时期文坛首先发出了“立人”的声音,并以其独特的艺术美感开启了新时期文学“个人化”叙事的源头。     

M-quantile models with application to poverty mapping

Over the last decade there has been growing demand for estimates of population characteristics at small area level. Unfortunately, cost constraints in the design of sample surveys lead to small sample sizes within these areas and as a result direct estimation, using only the survey data, is inappropriate since it yields estimates with unacceptable levels of precision. Small area models are designed to tackle the small sample size problem. The most popular class of models for small area estimation is random effects models that include random area effects to account for between area variations. However, such models also depend on strong distributional assumptions, require a formal specification of the random part of the model and do not easily allow for outlier robust inference. An alternative approach to small area estimation that is based on the use of M-quantile models was recently proposed by Chambers and Tzavidis (Biometrika 93(2):255–268, 2006) and Tzavidis and Chambers (Robust prediction of small area means and distributions. Working paper, 2007). Unlike traditional random effects models, M-quantile models do not depend on strong distributional assumption and automatically provide outlier robust inference. In this paper we illustrate for the first time how M-quantile models can be practically employed for deriving small area estimates of poverty and inequality. The methodology we propose improves the traditional poverty mapping methods in the following ways: (a) it enables the estimation of the distribution function of the study variable within the small area of interest both under an M-quantile and a random effects model, (b) it provides analytical, instead of empirical, estimation of the mean squared error of the M-quantile small area mean estimates and (c) it employs a robust to outliers estimation method. The methodology is applied to data from the 2002 Living Standards Measurement Survey (LSMS) in Albania for estimating (a) district level estimates of the incidence of poverty in Albania, (b) district level inequality measures and (c) the distribution function of household per-capita consumption expenditure in each district. Small area estimates of poverty and inequality show that the poorest Albanian districts are in the mountainous regions (north and north east) with the wealthiest districts, which are also linked with high levels of inequality, in the coastal (south west) and southern part of country. We discuss the practical advantages of our methodology and note the consistency of our results with results from previous studies. We further demonstrate the usefulness of the M-quantile estimation framework through design-based simulations based on two realistic survey data sets containing small area information and show that the M-quantile approach may be preferable when the aim is to estimate the small area distribution function.     

On the Need for Restricting the Probabilistic Analysis in Risk Assessments to Variability

It is common perspective in risk analysis that there are two kinds of uncertainties: i) variability as resulting from heterogeneity and stochasticity (aleatory uncertainty) and ii) partial ignorance or epistemic uncertainties resulting from systematic measurement error and lack of knowledge. Probability theory is recognized as the proper tool for treating the aleatory uncertainties, but there are different views on what is the best approach for describing partial ignorance and epistemic uncertainties. Subjective probabilities are often used for representing this type of ignorance and uncertainties, but several alternative approaches have been suggested, including interval analysis, probability bound analysis, and bounds based on evidence theory. It is argued that probability theory generates too precise results when the background knowledge of the probabilities is poor. In this article, we look more closely into this issue. We argue that this critique of probability theory is based on a conception of risk assessment being a tool to objectively report on the true risk and variabilities. If risk assessment is seen instead as a method for describing the analysts’ (and possibly other stakeholders’) uncertainties about unknown quantities, the alternative approaches (such as the interval analysis) often fail in providing the necessary decision support.     

形成性评估与大学生课外英语自主学习

大学生具有较强的课外英语自主学习意识,但并未都转化为相应的课外英语自主学习行为。高质量的形成性评估可以促进大学生课外自主学习意识向自主学习行为的迁徙,提高大学生的英语自主学习能力。