Examples of the use of an equivalence theorem in constructing optimum experimental designs for random-effects nonlinear regression models

The problem considered is that of finding an optimum measurement schedule to estimate population parameters in a nonlinear model when the patient effects are random. The paper presents examples of the use of sensitivity functions, derived from the General Equivalence Theorem for D-optimality, in the construction of optimum population designs for such schedules. With independent observations, the theorem applies to the potential inclusion of a single observation. However, in population designs the observations are correlated and the theorem applies to the inclusion of an additional measurement schedule. In one example, three groups of patients of differing size are subject to distinct schedules. Numerical, as opposed to analytical, calculation of the sensitivity function is advocated. The required covariances of the observations are found by simulation.     

近代资本主义生产生活方式对中国传统慈善事业的影响——以北京为例

以交通、通讯、新闻舆论等为典型代表的近代西方资本主义生产与生活方式传入中国后，它们或便利救济物资的调配，或加速救助对象的区域流动，或监督与制约救济事务的运转，或宣传与流播新型慈善思想等，从整体上对中国传统慈善活动的近代转型发挥强大的刺激与推动作用。     

从“知识考古”到“美学解救”——论现代“人”的福柯式解构

笛卡尔以来，主体问题始终是现代哲学最为核心的问题。但是，从哲学的语言论转向开始，主体已经声名狼藉，主体哲学的范式被视为陈腐过时了，传统的主体之争已经没有意义，无论语言是第一位，或者自我意识的个体优先，这两个范式中的任何一个都凸现和遮蔽着什么，将这两者联系起来或者寻找一种介于这两种范式之间的思路倒是可能的，如米歇尔福柯之路。     

对彩电行业拓展农村市场的思考

通过对中国彩电业现状的阐述,重点分析了农村彩电市场的需求现状特点及发展趋势,从产品、价格、广告、营销渠道和经营模式方面分析了彩电企业进入农村市场的策略。     

2002年中国儿童文学理论批评年度综述

2002年中国儿童文学理论批评的重要特别是对当下儿童文学热点、焦点问题的深刻关注,2002年中国儿童文学的热点、焦点问题大致在以下数端:关于第六届亚洲儿童文学大会;关于低龄化写作;关于儿童文学的推广;关于科幻文学;关于成长小说等。对当下儿童文学作家作品的批评及文体建设也是这一年关注较多的内容。     

浅议民事责任竞合

违约责任与侵权责任竞合是由于某种违反民事义务的行为既符合违约责任构成要件又符合侵权责任构成要件 ,从而在法律上导致多种民事责任并存和冲突所产生的现象。因此 ,采取责任聚合与自由选择诉因的措施来解决责任竟合 ,以期充分保护受害方权利 ,消灭责任重叠可能导致的不公平 ,合并不重叠部分的责任。     

论我国法院调解的促进和规范

随着经济的发展 ,法制的完善以及审判方式改革的深化 ,法院调解这一纠纷解决方式以其独特的优点 ,在司法实践中 ,越来越显示其重要性。时代赋予法院调解新的价值的同时 ,也使其原有的法律规定弊端凸现。本文拟从法院调解三原则的地位分析中寻找促进和规范法院调解的途径 ,并运用新证据规则加以落实。     

中日文化差异与日语教学

中日两国一衣带水,相互毗邻,有着两千多年的友好交往历史。在语言文字方面两国人民互相学习,相互影响,有不少相同、相似之处。但其中也有一些看似相同,实际上已经出现差异并具有特色的词汇和习俗,弄清这些词汇和习俗差异对我们学习日语和同日本人交流大有益处。尤其是在日语教学中,把这些词汇与习俗的异同及时渗透给学生,把中日文化的对比融入日语语言教学中,既可大大地活跃课堂气氛,又可提高学生的积极性和交际水平、应用能力。     

Non-ignorable missing covariate data in survival analysis: a case-study of an International Breast Cancer Study Group trial

Summary.  Non-ignorable missing data, a serious problem in both clinical trials and observational studies, can lead to biased inferences. Quality-of-life measures have become increasingly popular in clinical trials. However, these measures are often incompletely observed, and investigators may suspect that missing quality-of-life data are likely to be non-ignorable. Although several recent references have addressed missing covariates in survival analysis, they all required the assumption that missingness is at random or that all covariates are discrete. We present a method for estimating the parameters in the Cox proportional hazards model when missing covariates may be non-ignorable and continuous or discrete. Our method is useful in reducing the bias and improving efficiency in the presence of missing data. The methodology clearly specifies assumptions about the missing data mechanism and, through sensitivity analysis, helps investigators to understand the potential effect of missing data on study results.     

ASSESSING CONGRUENCEAMONG DISTANCE MATRICES: SINGLE-MALT SCOTCH WHISKIES REVISITED

A test of congruence among distance matrices is described. It tests the hypothesis that several matrices, containing different types of variables about the same objects, are congruent with one another, so they can be used jointly in statistical analysis. Raw data tables are turned into similarity or distance matrices prior to testing; they can then be compared to data that naturally come in the form of distance matrices. The proposed test can be seen as a generalization of the Mantel test of matrix correspondence to any number of distance matrices. This paper shows that the new test has the correct rate of Type I error and good power. Power increases as the number of objects and the number of congruent data matrices increase; power is higher when the total number of matrices in the study is smaller. To illustrate the method, the proposed test is used to test the hypothesis that matrices representing different types of organoleptic variables (colour, nose, body, palate and finish) in single‐malt Scotch whiskies are congruent.