Detecting homogeneous segments in DNA sequences by using hidden Markov models

In recent years there has been a rapid growth in the amount of DNA being sequenced and in its availability through genetic databases. Statistical techniques which identify structure within these sequences can be of considerable assistance to molecular biologists particularly when they incorporate the discrete nature of changes caused by evolutionary processes. This paper focuses on the detection of homogeneous segments within heterogeneous DNA sequences. In particular, we study an intron from the chimpanzee α-fetoprotein gene; this protein plays an important role in the embryonic development of mammals. We present a Bayesian solution to this segmentation problem using a hidden Markov model implemented by Markov chain Monte Carlo methods. We consider the important practical problem of specifying informative prior knowledge about sequences of this type. Two Gibbs sampling algorithms are contrasted and the sensitivity of the analysis to the prior specification is investigated. Model selection and possible ways to overcome the label switching problem are also addressed. Our analysis of intron 7 identifies three distinct homogeneous segment types, two of which occur in more than one region, and one of which is reversible.     

The Semiparametric Normal Variance-Mean Mixture Model

We study the normal variance-mean mixture model from a semiparametric point of view, i.e. we let the mixing distribution belong to a non-parametric family. The main results are consistency of the non-parametric maximum likelihood estimator and construction of an asymptotically normal and efficient estimator for the Euclidian part of the parameter. We study the model according to the theory outlined in the monograph by Bickel et al. (1993) and apply a general result (based on the theory of empirical processes) for semiparametric models from van der Vaart (1996) to prove asymptotic normality and efficiency of the proposed estimator.     

试论时间价值观

时间是一种重要的资源。时间价值观是个体以自身的需要为尺度对时间重要性的稳定态度和观念。时间价值观含有时间资源观、时间效率观、时机观、时间顺序观等方面的意义。时间价值观的结构可以有不同的划分。时间价值观受社会文化传统、个体的年龄因素、个体性格、社会环境等因素的影响。心理学对时间价值观的研究在理论上和应用中都有着重要的意义     

多方发挥物理实验教学的职能作用

当前我国医学教育中物理实验教学存在弱点:对物理教育不重视,实验条件差,仪器、设备陈旧,实验选项过时,实验课时少.针对存在的问题及现状,在现有的条件之内,我们提出了物理实验课的改进措施:认真做好实验准备,发挥教师的主导作用,督查学生亲自动手,利用现有仪器设备,不断改善实验条件,重视教学情况的反馈信息.     

注重素质培养,实现教育实习的目的

面对实习学校设备参差不齐,指导教师素质有高有低,实习学生来源、民族、性别比例不均的状况,我校教育实习相应地采取了城乡结合式、基地式等多种形式.在实习中,通过准备、实习、总结三个阶段,加强学生教风、教态、仪表、行为、着装、语言和板书的专门素质教育,以期达到教育实习的目的.     

球墨铸铁曲轴的气体软氮化

柴油机的珠墨铸铁曲轴系重要零件,气体软氮化应用到球墨铸铁领域还是一种新工艺,而且比中频淬火效果好,提高了曲轴的抗疲劳和抗磨损的能力。本文对气体软氮化的基本原理、设备、工艺参数的选择和催渗方法进行了探讨,对软氮化后曲轴的尺寸形状误差、光洁度和机械性能的提高等进行了较详细的试验、分析和比较,结果,经气体软氮化后的曲轴不但尺寸形站误差符合图纸要求外,而且抛去轻微氧化层后光洁度还略有提高,曲轴安全系数由1.3～1.6提高到1.70～1.77,并且一般不再发生疲劳断(?),使用寿命比原来寿命增加3.32倍以上。     

晋西三川河流域的地表组成物质及其与土壤侵蚀的关系

地表组成物质是影响三川河流域土壤侵蚀及滑坡发育的重要因素。本文在分析该流域的地表组成物质的类型、性质及分布规律的基础上,探讨了地表组成物质与土侵馒蚀的关系。     

Nonparametric control charts based on runs and Wilcoxon-type rank-sum statistics

In this article, we introduce three new distribution-free Shewhart-type control charts that exploit run and Wilcoxon-type rank-sum statistics to detect possible shifts of a monitored process. Exact formulae for the alarm rate, the run length distribution, and the average run length (ARL) are all derived. A key advantage of these charts is that, due to their nonparametric nature, the false alarm rate (FAR) and in-control run length distribution is the same for all continuous process distributions. Tables are provided for the implementation of the charts for some typical FAR values. Furthermore, a numerical study carried out reveals that the new charts are quite flexible and efficient in detecting shifts to Lehmann-type out-of-control situations.     

Nonparametric and semiparametric estimation of the three way receiver operating characteristic surface

In many situations the diagnostic decision is not limited to a binary choice. Binary statistical tools such as receiver operating characteristic (ROC) curve and area under the ROC curve (AUC) need to be expanded to address three-category classification problem. Previous authors have suggest various ways to model the extension of AUC but not the ROC surface. Only simple parametric approaches are proposed for modeling the ROC measure under the assumption that test results all follow normal distributions. We study the estimation methods of three-dimensional ROC surfaces with nonparametric and semiparametric estimators. Asymptotical results are provided as a basis for statistical inference. Simulation studies are performed to assess the validity of our proposed methods in finite samples. We consider an Alzheimer's disease example from a clinical study in the US as an illustration. The nonparametric and semiparametric modelling approaches for the three way ROC analysis can be readily generalized to diagnostic problems with more than three classes.     

长三角科技资源配置能力与城市化进程的协调耦合关系研究

科技资源配置能力已成为长江地区城市化进程的重要推力。因此,在构建科技资源与城市化耦合系统评价指标体系的基础上,利用耦合协调度模型综合评价长江区域科技资源配置与城市化的交互耦合关系。结果显示:从时间维度看,研究期内长三角科技资源配置能力与城市化进程之间的耦合关系基本上处于磨合阶段,耦合协调度以低度协调耦合状态为主并逐步过渡到中度协调耦合状态;从空间维度看,长三角各城市的科技资源配置与城市化耦合协调度在极度协调耦合、高度协调耦合、中度协调耦合、低度协调耦合四个阶段均有分布,层级分明且大部分城市尚处于低度协调耦合状态。