Robustness of a Class of Partial Diallel Cross Designs to the Unavailability of a Complete Block of Observations

Complete and partial diallel cross designs are examined as to their construction and robustness against the loss of a block of observations. A simple generalized inverse is found for the information matrix of the line effects, which allows evaluation of expressions for the variances of the line-effect differences with and without the missing block. A-efficiencies, based on average variances of the elementary contrasts of the line-effects, suggest that these designs are fairly robust. The loss of efficiency is generally less than 10%, but it is shown that specific comparisons might suffer a loss of efficiency of as much as 40%.     

Severely Traumatized Siblings: A Treatment Strategy

Siblings who have suffered severe trauma and disrupted attachment relate to one another in ways that interfere with individual development, the chance to benefit from connections with adults, the establishment of healthy sibling relationships, and the working through of traumatic experiences. The authors use case examples to illustrate four distinct sibling patterns: absent, adult lockout, half and half, and trauma shield. The authors highlight the importance of recognizing these types and then varying the therapist's treatment stance to pursue five goals. These include suspending problematic sibling relationships to create room for bonding with caring adults, transferring attachment behaviors and impulses to a receptive adult, resuming healthy individual development, forming more adaptive sibling connections, and expressing shared traumatic content.     

Three Object Relations Models of Couple Treatment

This article describes three different approaches to the treatment of couples, all based on different versions of object relations theories. Object relations as a term has various meanings embodying different theoretical assumptions. It is used differentially to highlight certain aspects of clinical phenomena, to connote certain developmental paradigms, and to signal the importance of real, interactional aspects of human behavior. The three therapeutic approaches to work with couples illustrate some of the ways that the greater conceptual complexity of object relations theories affects how love is explained, couple conflicts defined, and what makes for change in couples treatment. Understanding the basic assumptions of a given theory will enable us to increase our informed consent to the use of theory in our practices.     

The assessment of tumour response to treatment

Summary.  A parsimonious model for treated tumours is developed as a continuation of our previous work on regrowth curve theory. The statistical model belongs to the family of marginal non-linear models since the only linear parameters of the model are tumour specific and random facilitating parameter estimation. An important feature of the model is that it enables the estimation of the fraction of cancer cells surviving the treatment in vivo having easy-to-obtain longitudinal measurements of tumour volume. We compare several methods of estimation, including Lindstrom–Bates, iterated reweighted least squares and maximum likelihood. The last two methods are computed via the total estimating equations approach and variance least squares. The theory is illustrated with a photodynamic tumour therapy example.     

An alternative to the analysis of covariance for comparing randomized treatments

The problem of comparing mean responses for several treatments applied to a common population is considered. The analysis of co-variance ‘ANCOVA’ is frequently used to take advantage of covariate information in this setting, but in many cases ANCOVA's assumption of parallel regression functions precludes the use of ANCOVA. In this paper, an alternative method is developed which does not make this assumption     

Partitioning with Respect to a Control: Unequal Sample Sizes Case

This article describes a method for partitioning with respect to a control for the situation in which the treatment sample sizes are unequal and also for the situation where the treatment sample sizes are equal except for a few missing values. Calculation of the critical values required for finding confidence limits is discussed and tables are presented for the “almost equal” sample size case. An application of this method to length of stay data for congestive heart failure patients is also provided.     

An asymptotic distribution-free selection procedure for a two-way layout problem

This paper deals with an asymptotic distribution-free subset selection procedure for a two-way layout problem. The treatment effect with the largest unknown value is of interest to us. The block effect is a nuisance parameter in this problem. The proposed procedure is based on the Hodges-Lehmann estimators of location parameters. The asymptotic relative efficiency of the proposed procedure with the normal means procedure is evaluated. It is shown that the proposed procedure has a high efficiency.     

江苏省农村高血压防治知识知晓及治疗依从性分析

目的：分析江苏省农村地区高血压患者防治知识知晓和依从性情况及其影响因素,为探索农村高血压县乡村协作管理策略提供依据。方法：采用率等描述性分析防治知识知晓和治疗依从性,通过χ2检验和Logistic回归等推断性分析影响因素。结果：高血压防治知识知晓率为75.6%（苏南64.8%,苏中74.6%和苏北84.0%）,婚姻状况、文化程度和地区是影响因素;88.2%患者的服药依从性较好（苏南92.9%,苏中92.6%和苏北79.0%）,地区和防治知识知晓情况是影响因素。结论：不同地区需结合自身特点,组建县乡村高血压纵向协作团队,提高患者防治知识知晓和治疗依从性。     

基于ANSYS的热成形模具结构优化

基于冲压成型工艺试验分析系统,针对模具内材料受热膨胀将对模具导向装置及结构造成干涉的问题,利用有 限元分析软件ANSYS对模内温度场进行热力耦合分析,得出各部分材料的热膨胀程度。为基于正向压边模架的模内加 热装置提供可靠的实验参数和热力学设计依据,提高了模具结构设计的合理性,达到优化设计的目的。