Disembodied politics: commitment and formal distance in Rancière*

Abstract

In light of the theme and concerns of the present collection of essays, we may ask whether ‘distance in general’, and ‘critical distance in particular’ (Fredric Jameson), has truly disappeared with postmodernity. Proposing an immediate and interruptive political engagement with local issues, Jacques Rancière’s articulation of political mobilisation does seem to confirm this claim. Upon further inspection, however, his emancipatory politics repeat the same mistake of valuing an abstract universal at the expense of a concrete particular, however paradoxical this may seem at first sight. The present article develops this thesis in three moments. On the first hand, it highlights Rancière’s notion of conflict as being institutive of politics. Secondly, it connects this ‘sensible’, and Rancière’s understanding of politics as being aesthetic, to Kant’s ‘Transcendental Aesthetics’. The French author sees in the leading section of the first Critique the grounding possibility of (I) freeing up time and space within the social realm; (II) the representation of a common political surface that can be reshaped; (III) political equality; (IV) emancipation. The last section shows how this recourse to the transcendental subject in Rancière’s politics follows and embraces a traditional position in the history of philosophy whereby identity is denigrated at the profit of a disembodied universalism.     

Adaptive designs for pivotal trials: discussion points from the PSI Adaptive Design Expert Group

The Committee for Medicinal Products for Human Use (CHMP) is currently preparing a guideline on 'methodological issues in confirmatory clinical trials with flexible design and analysis plan'. PSI (Statisticians in the Pharmaceutical Industry) sponsored a meeting of pharmaceutical statisticians with an interest in the area to share experiences and identify potential opportunities for adaptive designs in late-phase clinical drug development. This article outlines the issues raised, resulting discussions and consensus views reached. Adaptive designs have potential utility in late-phase clinical development. Sample size re-estimation seems to be valuable and widely accepted, but should be made independent of the observed treatment effect where possible. Where unblinding is necessary, careful consideration needs to be given to preserving the integrity of the trial. An area where adaptive designs can be particularly beneficial is to allow dose selection in pivotal trials via adding/dropping treatment arms; for example, combining phase II and III of the drug development program. The more adaptations made during a late-phase clinical trial, the less likely that the clinical trial would be considered as a confirmatory trial. In all cases it would be advisable to consult with regulatory agencies at the protocol design stage. All involved should remain open to scientifically valid opportunities to improve drug development.     

Qui recrute et comment ? L’expertise économique des professionnels de l’insertion des jeunes

How do job placement specialists acquire knowledge of the markets, and do they put it to use? At deliberative committee meetings on the funding of youth integration projects, we observed the construction of a shared representation of the workings of local-level job markets. Integration professionals develop their economic expertise primarily from two sources to which they are professionally close: the young jobseekers themselves and the vocational training professionals. The unequal distribution of economic expertise is intensified by structural differences in the capacity to put it to use for each of the deliberative stakeholders.     

Frontline workers' competency in activation work

Frontline workers play a crucial role in implementing activation policies. Nevertheless, research on what competencies are required for activation work is limited. We explored activation competency based on a survey of 1,735 frontline workers in the Norwegian labour and welfare administration. Factor analysis revealed two distinct underlying dimensions in activation competency: market competency and user‐oriented competency. We found that the social workers in the study viewed themselves as having significantly less market competency and slightly more user‐oriented competency than non‐social workers have, but the differences were small. The results also indicate that these effects are partially mediated by attitudes towards conditionality. The results give reason to treat activation competencies as twofold and raise the question of whether social work education improves frontline workers' competency in activation work compared with frontline workers with other educational backgrounds.     

文化大发展大繁荣视角的区域文化创新探论

没有社会主义文化的繁荣发展,就没有社会主义现代化。同样,中华民族的伟大复兴,也必然伴随中华文化的繁荣兴盛。而要推动社会主义文化大发展大繁荣,实现中华文化的复兴昌盛,除了要始终坚持中国特色社会主义文化发展道路之外,还要从区域经济发展的不平衡性和空间资源的整体性、关联度出发,注重区域文化的研究和创新,解放发展区域文化生产力。     

Additional results for 'Sequential design approaches for bioequivalence studies with crossover designs'

In 2008, this group published a paper on approaches for two‐stage crossover bioequivalence (BE) studies that allowed for the reestimation of the second‐stage sample size based on the variance estimated from the first‐stage results. The sequential methods considered used an assumed GMR of 0.95 as part of the method for determining power and sample size. This note adds results for an assumed GMR = 0.90. Two of the methods recommended for GMR = 0.95 in the earlier paper have some unacceptable increases in Type I error rate when the GMR is changed to 0.90. If a sponsor wants to assume 0.90 for the GMR, Method D is recommended. Copyright © 2011 John Wiley & Sons, Ltd.     

A Bayesian adaptive blinded sample size adjustment method for risk differences

Adaptive sample size adjustment (SSA) for clinical trials consists of examining early subsets of on trial data to adjust estimates of sample size requirements. Blinded SSA is often preferred over unblinded SSA because it obviates many logistical complications of the latter and generally introduces less bias. On the other hand, current blinded SSA methods for binary data offer little to no new information about the treatment effect, ignore uncertainties associated with the population treatment proportions, and/or depend on enhanced randomization schemes that risk partial unblinding. I propose an innovative blinded SSA method for use when the primary analysis is a non‐inferiority or superiority test regarding a risk difference. The method incorporates evidence about the treatment effect via the likelihood function of a mixture distribution. I compare the new method with an established one and with the fixed sample size study design, in terms of maximization of an expected utility function. The new method maximizes the expected utility better than do the comparators, under a range of assumptions. I illustrate the use of the proposed method with an example that incorporates a Bayesian hierarchical model. Lastly, I suggest topics for future study regarding the proposed methods. Copyright © 2015 John Wiley & Sons, Ltd.     

论涉己态度问题--从心灵哲学与语言哲学的视角看

一般认为，涉己态度对传统关于态度及其归属的解释框架提出了挑战，即它引发人们重新考虑态度内容的本质及态度归属的语义解释问题。对此，文献中主要提出了三种解决方案———弗雷格式的解释、三元关系的解释和自我归属的解释。研究发现，这三种解决方案都存在问题，并且涉己态度的特殊性以及涉己态度报告在自然语言中的存在性也值得怀疑。鉴于此，论文提出涉己态度问题需要结合态度及态度归属研究领域的其他难题以及自然语言中的相关语言事实来进一步研究。     

A review and re‐interpretation of a group‐sequential approach to sample size re‐estimation in two‐stage trials

In this paper, we review the adaptive design methodology of Li et al. (Biostatistics 3 :277–287) for two‐stage trials with mid‐trial sample size adjustment. We argue that it is closer in principle to a group sequential design, in spite of its obvious adaptive element. Several extensions are proposed that aim to make it even more attractive and transparent alternative to a standard (fixed sample size) trial for funding bodies to consider. These enable a cap to be put on the maximum sample size and for the trial data to be analysed using standard methods at its conclusion. The regulatory view of trials incorporating unblinded sample size re‐estimation is also discussed. © 2014 The Authors. Pharmaceutical Statistics published by John Wiley & Sons, Ltd.     

La dynamique des professions à l'épreuve de la féminisation : l'ascension atypique des femmes commissaires

There are more female constables at the top of the hierarchy, especially in very male oriented services, then at the bottom of the police force. And differences of carrier between male and female constables are not so big. These two original points can only be explained if they are put in the light of professional, political and anthropological prospectives that governs the profession in process.