我国二板市场公司治理思路

对我国二板市场公司治理思路进行了研究,指出A、B两股市场皆多以国有企业为主,资本市场的监督与管理存在不规范问题,二板市场的建立必须以此为鉴,认为二板市场的治理结构应着手于建立经理层的激励机制、健全董事会制度、正确理解企业上市的实质性要求,并就如何对上市企业和股权流通市场进行有效监管以及企业退出机制的构建等问题进行了分析。     

湖南省农产品流通效率测度及其影响因素研究 ——基于DEA-Malmquist指数和Tobit模型

文章以2009—2018年湖南省13个地级市为研究对象,构建DEA-Malmquist指数模型对湖南省农产品流通效率进行静态和动态分析。结果显示:近年来湖南省农产品流通全要素生产率整体提升,但是除长沙、衡阳和岳阳外,其他地区的规模效率在逐步下降,技术效率提升不稳定。这表明农产品流通业投入产出结构不合理是制约湖南省农产品流通效率提升的主要因素,农产品流通业在技术创新与管理创新方面的缺乏也是抑制湖南省农产品流通效率提高的因素。采用Tobit模型考察农产品流通效率的影响因素,结果表明:资本和劳动力投入、基础设施建设水平、信息化水平和居民消费水平都在不同程度上影响湖南省农产品流通效率。因此,应加快湖南省农业结构调整步伐,以提升农业供给体系的整体质量和效率。     

双循环新发展格局下中国双向直接投资研究

构建以国内大循环为主体、国内国际双循环相互促进的新发展格局,是对未来中国经济发展路径做出的重大战略部署,作为连接国内国际双循环的纽带,双向直接投资的发展战略和路径面临重塑和调整。研究认为,应当以推动新时代科技创新和产业升级为目标,提高双向直接投资的质量,畅通供应链和产业链; 以“一带一路”倡议为依托,通过更高水平的双向投资带动中国与沿线国家贸易水平的提高; 建设高水平自贸区和自贸港,提高对外开放标准,更高质量吸引外资,提升参与国际大循环的技术含量和自主性; 在畅通要素流动领域,建立更加完善的现代化物流体系,建设更高标准的要素流通市场体系,降低制度性交易费用,提高生产率和对高质量外资的吸引能力。     

浦东农村集体建设用地流转研究

当前,浦东集体建设用地低效、闲置和浪费现象比较普遍,资产价值尚未真正体现,尤其是乡镇工业用地聚集度低,布局分散,点多规模小,建筑密度和容积率低;工业产出率不高,厂房、场地闲置严重。通过集体建设用地的流转,实施土地二次开发,可以有效利用存量用地,盘活土地资源。要通过确权登记发证,进一步理清产权界限,避免产权主体虚置与权能重叠;建立合理的收益分配机制,确保农民利益;加快相关财政体制衔接．保障流转工作有序推进。     

土地流转视角的农村人力资本流动及其对策建议

农村人力资本的合理流动是土地流转的前提。土地流转能够有效提高土地资源配置效率．进一步激活农村富余劳动力的转移。观念障碍、信息障碍、成本障碍、技能障碍、制度障碍、职位障碍、收益障碍和公平障碍等八大障碍,较严重地制约了农村人力资本的流动,阻碍了土地流转的进一步实施。必须消除这些障碍,进一步促进人力资本有序流动。     

Confidence interval estimation of the difference between paired AUCs based on combined biomarkers

In many diagnostic studies, multiple diagnostic tests are performed on each subject or multiple disease markers are available. Commonly, the information should be combined to improve the diagnostic accuracy. We consider the problem of comparing the discriminatory abilities between two groups of biomarkers. Specifically, this article focuses on confidence interval estimation of the difference between paired AUCs based on optimally combined markers under the assumption of multivariate normality. Simulation studies demonstrate that the proposed generalized variable approach provides confidence intervals with satisfying coverage probabilities at finite sample sizes. The proposed method can also easily provide P-values for hypothesis testing. Application to analysis of a subset of data from a study on coronary heart disease illustrates the utility of the method in practice.     

试论伪造货币罪的犯罪构成要件

伪造货币罪是最严重的货币犯罪,具体表现为仿照真货币制造假货币的行为。该行为的特点是“无中生有”、“仿真造假”。其仿制的对象既包括人民币,又包括外币,但不包括信用货币。伪造货币罪在主观方面应以“意图流通”为必备条件。根据刑法规定,该罪的犯罪主体仅限于自然人,不包括单位。     

家庭承包经营体制的创新与土地的适度规模经营

土地集约化、规模化经营是我国农业生产发展的必然趋势.随着生产力的提高和宏观环境的变化,土地家庭承包制的缺陷也开始显现.所以,在国家政策法律支持下进行家庭承包经营体制的创新发展,采取不同的模式加速土地的集中和规模化经营,是提高我国农业劳动生产力,增加农民收入的主要方向.     

An intuitive risk factors search algorithm: usage of the Bayesian network technique in personalized medicine

The article focuses on the application of the Bayesian networks (BN) technique to problems of personalized medicine. The simple (intuitive) algorithm of BN optimization with respect to the number of nodes using naive network topology is developed. This algorithm allows to increase the BN prediction quality and to identify the most important variables of the network. The parallel program implementing the algorithm has demonstrated good scalability with an increase in the computational cores number, and it can be applied to the large patients database containing thousands of variables. This program is applied for the prediction for the unfavorable outcome of coronary artery disease (CAD) for patients who survived the acute coronary syndrome (ACS). As a result, the quality of the predictions of the investigated networks was significantly improved and the most important risk factors were detected. The significance of the tumor necrosis factor-alpha gene polymorphism for the prediction of the unfavorable outcome of CAD for patients survived after ACS was revealed for the first time.     

Testing for bioequivalence of highly variable drugs from TR‐RT crossover designs with heterogeneous residual variances

Traditional bioavailability studies assess average bioequivalence (ABE) between the test (T) and reference (R) products under the crossover design with TR and RT sequences. With highly variable (HV) drugs whose intrasubject coefficient of variation in pharmacokinetic measures is 30% or greater, assertion of ABE becomes difficult due to the large sample sizes needed to achieve adequate power. In 2011, the FDA adopted a more relaxed, yet complex, ABE criterion and supplied a procedure to assess this criterion exclusively under TRR‐RTR‐RRT and TRTR‐RTRT designs. However, designs with more than 2 periods are not always feasible. This present work investigates how to evaluate HV drugs under TR‐RT designs. A mixed model with heterogeneous residual variances is used to fit data from TR‐RT designs. Under the assumption of zero subject‐by‐formulation interaction, this basic model is comparable to the FDA‐recommended model for TRR‐RTR‐RRT and TRTR‐RTRT designs, suggesting the conceptual plausibility of our approach. To overcome the distributional dependency among summary statistics of model parameters, we develop statistical tests via the generalized pivotal quantity (GPQ). A real‐world data example is given to illustrate the utility of the resulting procedures. Our simulation study identifies a GPQ‐based testing procedure that evaluates HV drugs under practical TR‐RT designs with desirable type I error rate and reasonable power. In comparison to the FDA's approach, this GPQ‐based procedure gives similar performance when the product's intersubject standard deviation is low (≤0.4) and is most useful when practical considerations restrict the crossover design to 2 periods.