Defending the Family,Defending the Faith: An Analysis of The Family: A Proclamation to the World,Religious Identity,and the Politics of Same-Sex Marriage in a Mormon Community

In this article, we apply Peter Berger's theory of religion as a social construct to learn how The Church of Jesus Christ of Latter-day Saints (the Mormon Church) advances a heteronormative view of family relationships in the United States using a document titled The Family: A Proclamation to the World. Furthermore, applying cultural studies theory, we examine how believing Mormons negotiate the tension that arises when their secular values compete with those expressed by Church leaders. We argue that, although the Proclamation addresses a number of issues, the Church offers a closed text that emphasizes war narratives in which same-sex marriage is portrayed as a threat to LDS identity and the heteronormative family. This closed text is further legitimized by emphasis on the authority of Church leaders as oracles of God. The study participants largely accept the dominant narrative, and those who reject it, do so with some trepidation.     

Parameter estimation of the censored δ-shock model on uniform interval

The censored δ-shock model is a special kind of shock model and it has very important research values in the reliability theory. In this paper, we discuss the parameter estimation of the censored δ-shock model when the inter-arrival times between two successive shocks follows uniform distribution on [a, b]. With the maximum likelihood estimation, we obtain the parameter estimator and expectation of estimator and lifetime of the model. By numerical simulation, we get the empirical result on the estimator of δ and the relationship between δ and other parameters.     

Generalized Kerridge’s inaccuracy measure for conditionally specified models

Recently, conditional Renyi’s divergence of order α and Kerridge’s inaccuracy measures are studied by Navarro et al. (2014 Navarro, J., Sunoj, S.M., Linu, M.N. (2014). Characterizations of bivariate models using some dynamic conditional information divergence measures. Commun. Stat. Theory Methods 43:1939–1948.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]). In the present article, a generalized dynamic conditional Kerridge’s inaccuracy measure is introduced, which can be represented as the sum of conditional Renyi’s divergence and Renyi’s entropy. Some useful bounds are obtained using the concept of likelihood ratio order. The results are extended to weighted distributions. Sufficient conditions are obtained for the monotonicity of the proposed measure. Characterizations for bivariate exponential conditional distribution are presented based on the proposed measure.     

A small but practically useful modification to the Hodrick–Prescott filtering: A note

The Hodrick–Prescott (HP) filtering is widely applied to decompose macroeconomic time series, such as real Gross Domestic Product, into cyclical and trend components. This paper presents a small but practically useful modification to this approach. The reason why this modified filtering is of practical use is that it provides not only identical trend estimates as the HP filtering but also extrapolations of the trend. We provide a proof based on a ridge regression representation of the modified HP filtering. This is mainly because it enhances our understanding of the approach.     

The exponentiated reduced Kies distribution: Properties and applications

Here we consider an exponentiated version of the reduced Kies distribution and discuss some of its properties. The parameters of the distribution are estimated by the method of maximum likelihood and illustrated with the help of certain real-life data sets. Asymptotic behavior of the maximum likelihood estimators of the parameters of the distribution is also studied by using certain simulated data sets.     

The Bayes rule of the variance parameter of the hierarchical normal and inverse gamma model under Stein's loss

For the variance parameter of the hierarchical normal and inverse gamma model, we analytically calculate the Bayes rule (estimator) with respect to a prior distribution IG (alpha, beta) under Stein's loss function. This estimator minimizes the posterior expected Stein's loss (PESL). We also analytically calculate the Bayes rule and the PESL under the squared error loss. Finally, the numerical simulations exemplify that the PESLs depend only on alpha and the number of observations. The Bayes rules and PESLs under Stein's loss are unanimously smaller than those under the squared error loss.     

Efficiency of the generalized-difference-based weighted mixed almost unbiased two-parameter estimator in partially linear model

In this paper, a generalized difference-based estimator is introduced for the vector parameter β in partially linear model when the errors are correlated. A generalized-difference-based almost unbiased two-parameter estimator is defined for the vector parameter β. Under the linear stochastic constraint r = Rβ + e, we introduce a new generalized-difference-based weighted mixed almost unbiased two-parameter estimator. The performance of this new estimator over the generalized-difference-based estimator and generalized- difference-based almost unbiased two-parameter estimator in terms of the MSEM criterion is investigated. The efficiency properties of the new estimator is illustrated by a simulation study. Finally, the performance of the new estimator is evaluated for a real dataset.     

Enabling robust assessment of QTc prolongation in early phase clinical trials

Since the implementation of the International Conference on Harmonization (ICH) E14 guideline in 2005, regulators have required a “thorough QTc” (TQT) study for evaluating the effects of investigational drugs on delayed cardiac repolarization as manifested by a prolonged QTc interval. However, TQT studies have increasingly been viewed unfavorably because of their low cost effectiveness. Several researchers have noted that a robust drug concentration‐QTc (conc‐QTc) modeling assessment in early phase development should, in most cases, obviate the need for a subsequent TQT study. In December 2015, ICH released an “E14 Q&As (R3)” document supporting the use of conc‐QTc modeling for regulatory decisions. In this article, we propose a simple improvement of two popular conc‐QTc assessment methods for typical first‐in‐human crossover‐like single ascending dose clinical pharmacology trials. The improvement is achieved, in part, by leveraging routinely encountered (and expected) intrasubject correlation patterns encountered in such trials. A real example involving a single ascending dose and corresponding TQT trial, along with results from a simulation study, illustrate the strong performance of the proposed method. The improved conc‐QTc assessment will further enable highly reliable go/no‐go decisions in early phase clinical development and deliver results that support subsequent TQT study waivers by regulators.